Behavior Activity Research Articles

Harm Reduction Behavioral Activation Teletherapy for People Who Inject Drugs: Development, Feasibility, and Acceptability

People who inject drugs (PWID) experience severe substance-related harms and yet have low rates of engagement in substance use disorder treatment. Low-barrier and telepsychology interventions represent promising strategies for engaging PWID in treatment, but few studies have tested the feasibility of these approaches among non-treatment-seeking PWID. A behavioral activation (BA) treatment for substance use was adapted through a harm reduction lens to assist PWID in working toward healthy, meaningful lives and achieving their goals. This study aims to: (a) describe the development and harm reduction–focused adaptation of the BA intervention, and (b) examine the feasibility and acceptability of administering a telepsychology BA treatment for substance use among non-treatment-seeking PWID. We recruited N = 23 PWID (65.2% White; 52.2% women; mean age 35.4 ± 7.8 years) from syringe services programs into an open trial and n = 19 received up to eight sessions of BA over 4 weeks. Qualitative treatment feedback interviews occurred at posttreatment. Among those who attended ≥1 session of treatment, 84% attended a second assessment, and 58% attended ≥7 intervention sessions. Feasibility challenges were primarily related to participant vulnerabilities (e.g., hospitalization, incarceration, loss of access to technology). Participants indicated high acceptance of the intervention and its telepsychology format. In conclusion, while PWID face significant barriers to engaging in treatment, some also demonstrate a desire, willingness, and capacity for psychological intervention. Remote interventions may help increase feasibility of treatment participation. Future studies should examine longer harm reduction-focused treatments for PWID that balance barriers to initial engagement with the need to reinforce treatment gains and improve long-term outcomes.

” I have not been doing it because of my fear of something happening”. Exploring Perspectives on Healthy Dietary Behavior and Physical Activity in Mexican Pregnant Women and Healthcare Professionals – A Qualitative Study

Background: Mexico exhibits one of the highest prevalences of overweight and obesity globally, accompanied by a surge in non-communicable diseases, which in turn leads to elevated mortality rates. Existing efforts to address rising obesity rates have shown limited effectiveness. Maternal weight, diet, and physical activity during pregnancy affect the mother's and offspring's health. Despite the importance of obtaining and engaging in healthy behaviors during pregnancy, little is known about which factors impact these behaviors among pregnant women in Mexico. Aim: This study explored perspectives on factors impacting healthy dietary behaviors and physical activity in pregnancy from pregnant women and healthcare professionals in Mexico. Methods: We conducted semi-structured interviews with 11 pregnant women and 12 healthcare professionals working in prenatal care. Data were analyzed using qualitative content analysis in a stepwise inductive approach. Results: Three overall themes emerged; classifying factors at the 1) individual, 2) relational, and 3) healthcare system levels. At the individual level, challenges with lack of time and competing priorities, as well as knowledge of healthy dietary behaviors and physical activity were identified. On the relational level, influencing factors encompassed financial, social, and emotional support, along with descriptive norms. At the healthcare system level, guidelines for physical activity during pregnancy and the quality of care were discerned. Conclusion: The study identified factors impacting healthy dietary behaviors and physical activity in pregnancy in Mexico. Important considerations for future interventions include addressing socio-cultural norms around healthy dietary behavior and physical activity in pregnancy and involvement of the pregnant women's families, closest social networks, and the healthcare professionals working at the prenatal care unit.

The Moderation Effect of Approach Motivation Between Schizotypy and Creative Ideational Behavior.

The schizotypy-creativity link has been studied from different perspectives over the past few decades, yet the results of this relationship are inconsistent in the literature. Previous studies have suggested that two basic motivational systems-Behavioral Inhibition System (BIS, avoidance motivation) and Behavioral Activation System (BAS, approach motivation)-underlie the relationship between schizotypy and creativity. Few empirical studies, however, have examined how the relationship interacts with other variables. This study fills these gaps and explores the role of the approach and avoidance motivation assessed by trait behavioral activation and inhibition in the link between schizotypy as a dimensional personality trait and creative ideational behavior as a measure of creativity. Undergraduate students (N = 388) completed questionnaires including the Schizotypal Personality Questionnaire (SPQ) measuring 3 dimensions of schizotypy, Runco Ideational Behavior Scale (RIBS) measuring creative ideational behavior, and BIS/BAS Scales measuring trait behavioral motivation. Bivariate Pearson correlation was computed, and hierarchical linear regression was performed to explore the effects of schizotypy, BIS/BAS, and their interaction on creative ideational behavior. The conditional effect of schizotypy based on different levels of the moderator was further tested. The total score, positive dimension and disorganized dimension of SPQ were all positively correlated with RIBS, BAS, and BIS. Negative dimension of SPQ was not significantly correlated with the RIBS score but was positively correlated with BIS. Additionally, after controlling gender and age, BAS significantly moderated the relationship between the positive and disorganized dimensions of schizotypy and creative ideational behavior measured by RIBS. However, BIS was not a significant moderator. The findings of this study regarding the relationships between different dimensions of schizotypy, two motivational systems, and creative ideational behavior were mostly consistent with previous findings. The significant moderated effect of BAS on the relationship between two dimensions of schizotypy and creative ideational behavior made significant contributions to the understanding of the relationship between schizotypy and creativity.

A lifestyle physical activity intervention for women in alcohol treatment: A pilot randomized controlled trial

IntroductionCompared to men, women with alcohol use disorder (AUD) are more likely to drink to manage stress and negative affect. Given women's risk for poor drinking outcomes, it is critical to develop and test interventions that target these affective factors. Physical activity improves negative affect and has emerged as a promising adjunct to AUD treatment and, thus, may be especially valuable for women. MethodsFifty women with AUD (49.9 ± 12.0 years of age) participated in either a 12-week telephone-delivered lifestyle physical activity plus Fitbit (LPA + Fitbit) or a health education contact (HEC) control intervention following a partial hospital addictions treatment program. The study examined changes in drinking behaviors, mental health outcomes, and physical activity engagement post-intervention using both conventional test statistics and standard effect sizes. ResultsHigher rates of continuous abstinence during the 12-week period were observed in the LPA + Fitbit condition (55.6 %) than in the HEC condition (33.6 %); odds ratio = 2.97. However, among women who drank any alcohol during the 12-weeks, slightly higher rates of heavy drinking and drinks/day were observed among women in the LPA + Fitbit condition. Significant differences for improved mental health outcomes (including depression, anxiety, negative affect, positive affect, perceived stress, and behavioral activation) and increased self-reported physical activity were consistently observed among participants in the LPA + Fitbit condition, relative to HEC. ConclusionsThe LPA + Fitbit program had a positive impact on alcohol abstinence, mental health, and physical activity in adult women receiving treatment for AUD. Future research should continue to investigate the optimal implementation strategies, duration, and intensity of LPA interventions in the context of a fully-powered RCT.

A machine learning personalized treatment rule to optimize assignment to psychotherapies for grief among veterans

BackgroundComplex grief patterns are associated with significant suffering, functional impairments, health and mental health problems, and increased healthcare use. This burden may be even more pronounced among veterans. Behavioral Activation and Therapeutic Exposure (BATE-G) and Cognitive Therapy for Grief (CT-G) are two evidence-based interventions for grief. The goal of this study was to use a precision medicine approach to develop a personalized treatment rule to optimize assignment among these psychotherapies. MethodsWe analyzed data (N = 155) from a randomized clinical trial comparing BATE-G and CT-G. Outcome weighted learning was used to estimate an optimal personalized treatment rule. Baseline characteristics including demographics, social support, variables related to the death, and psychopathology dimensions were used as prescriptive factors of treatment assignment. ResultsThe estimated rule assigned 72 veterans to CT-G and 56 to BATE-G. Assigning participants according to this rule was estimated to lead to markedly lower mean grief level following 6 months from treatment compared to assigning everyone to either BATE-G (Vdopt – VBATE-G = −18.57 [95 % CI: (−29.41, −7.72)]) or CT-G (Vdopt – VBATE-G = −20.89 [95 % CI: (−30.7, −11.07)]) regardless of their characteristics. LimitationsParticipants were primarily male veterans, and identified with Black or White race. The estimated rule was not externally validated. ConclusionThe estimated rule used relatively simple, easily accessible, client characteristics to personalize assignment to treatment using a precision medicine approach based on machine learning and causal inference. Upon further validation, such a rule can be easily implemented in clinical practice to prescriptively maximize treatment benefits.

Construction of low-symmetrical charge-neutral Sn12-oxo football cage with the functionalized ligand

Tin-oxo clusters, as molecular model compounds of tin oxide materials, have attracted increasing attention. Although various tin-oxo clusters have been obtained, the systemic studies on ligand functionalization of tin-oxo clusters remain to be well developed. In this study, we adopted 3-aminopyrazine-2-carboxylic acid (HAPZC) as the functionalized ligand, and successfully synthesized a novel tin-oxo cluster [(n-BuSn)12(OH)6O14 (APZC)2]·2H2O (CTGU-SnC-3). Due to the functionalization of the APZC ligands, the structure and charge of Sn12 cage in CTGU-SnC-3 are all different from those of reported cationic football cage. This Sn12 cage in CTGU-SnC-3 presents the interesting low-symmetrical football framework with the functionalized ligands. Different from the reported cationic football cages, the CTGU-SnC-3 is charge-neutral structure without any counteranions. Moreover, the CTGU-SnC-3 exhibits hydrophobic behavior and catalytic activity in electrocatalytic CO2 reduction reaction.

Altered effective connectivity among face-processing systems in major depressive disorder.

Neuroimaging studies have revealed abnormal functional interaction during the processing of emotional faces in patients with major depressive disorder (MDD), thereby enhancing our comprehension of the pathophysiology of MDD. However, it is unclear whether there is abnormal directional interaction among face-processing systems in patients with MDD. A group of patients with MDD and a healthy control group underwent a face-matching task during functional magnetic resonance imaging. Dynamic causal modelling (DCM) analysis was used to investigate effective connectivity between 7 regions in the face-processing systems. We used a Parametric Empirical Bayes model to compare effective connectivity between patients with MDD and controls. We included 48 patients and 44 healthy controls in our analyses. Both groups showed higher accuracy and faster reaction time in the shape-matching condition than in the face-matching condition. However, no significant behavioural or brain activation differences were found between the groups. Using DCM, we found that, compared with controls, patients with MDD showed decreased self-connection in the right dorsolateral prefrontal cortex (DLPFC), amygdala, and fusiform face area (FFA) across task conditions; increased intrinsic connectivity from the right amygdala to the bilateral DLPFC, right FFA, and left amygdala, suggesting an increased intrinsic connectivity centred in the amygdala in the right side of the face-processing systems; both increased and decreased positive intrinsic connectivity in the left side of the face-processing systems; and comparable task modulation effect on connectivity. Our study did not include longitudinal neuroimaging data, and there was limited region of interest selection in the DCM analysis. Our findings provide evidence for a complex pattern of alterations in the face-processing systems in patients with MDD, potentially involving the right amygdala to a greater extent. The results confirm some previous findings and highlight the crucial role of the regions on both sides of face-processing systems in the pathophysiology of MDD.

Behavioral and electrocardiographic evaluation of Colossoma macropomum (Cuvier, 1818) indicates a safe concentration window for the use of Spilanthol in immersion baths

The use of natural products for the sedation and anesthesia of fish is already well established, with characteristics similar to or potentially superior to synthetic anesthetics. There is a significant advantage in terms of commercial accessibility compared to synthetic drugs, without compromising effectiveness and safety. Var. Oleracea, commonly known as jambu, is considered a medicinal plant. It contains spilanthol, an olefinic N-alkyl-amide with an isobutyl side chain. The supercritical oil of Spilanthes acmella (SOSA) exhibits anesthetic and sedative activity in fish. Our study aimed to evaluate the behavior and cardiac activity (ECG) of SOSA in seven groups: control, control vehicle, 20, 30, 40, 50 and 60 μL.L−1 in tambaqui (Colossoma macropomum). The animals were divided into two experiments: Experiment 1 (Behavioral), in which the latency for the loss and recovery of the animals' posture reflex in contact with the concentrations was evaluated. Experiment 2 (ECG), in which morphographic changes in the ECG were identified during treatment with various concentrations of SOSA. We conclude that concentrations of 20 μL.L−1 to 40 μL.L−1of SOSA were the most suitable for anesthesia due to the rapid reversibility of effects and minimal changes in the hemodynamics of C. macropomum in short-duration anesthesia.

Utilizing Ant Forest technology to foster sustainable behaviors: A novel approach towards environmental conservation

Amidst mounting environmental threats and exacerbated global risks from climate change, the urgency for sustainable behaviors has never been more critical, demanding concerted efforts to cultivate individual actions for environmental conservation. Ant Forest technology, a groundbreaking innovation for sustainable lifestyles, stands at the forefront of this battle, harnessing technological advancements to drive positive environmental impact and must be championed. This research investigates the dynamics of environmental conservation behaviors facilitated by Ant Forest Technology. Employing a theoretical framework integrating the Technology Acceptance Model (TAM) and Self-Determination Theory (SDT), the study explores the impact of autonomous and controlled motivation on attitudes, intentions, and conservation behaviors. Furthermore, the research assesses the influence of knowledge disseminated through Ant Forest Technology on users' intentions and behavior toward conservation behaviors. The study utilized the partial least square structural equation modeling in its analysis. Findings reveal that both motivational factors and knowledge significantly shape users' engagement in conservation behaviors activities through perceived ease of use and usefulness. These insights contribute to the development of effective policies and interventions aimed at harnessing Ant Forest Technology as a powerful tool for fostering widespread environmental conservation behaviors.

Protocol for a randomised controlled trial of ketamine versus ketamine and behavioural activation therapy for adults with treatment-resistant depression in the community

IntroductionAlthough short-term benefits follow parenteral ketamine for treatment-resistant major depressive disorder (TR-MDD), there are challenges that prevent routine use of ketamine by clinicians. These include acute dissociative effects of parenteral...

Effectiveness of an add-on brief group behavioral activation treatment for depression in psychiatric care: a randomized clinical trial.

Behavioral activation (BA) is an effective treatment for depression. We investigated the effectiveness of add-on group-format BA and peer support (PS) with treatment as usual (TAU) in a registered randomized clinical trial in psychiatric outpatient settings (ISRCTN10647845). Adult outpatients (N = 140) with major depressive disorder (MDD) and Patient Health Questionnaire (PHQ-9) score ≥10 were randomized into a) group BA, consisting of eight 90-minute weekly group sessions plus TAU; b) group PS, including eight 90-minute weekly group sessions plus TAU; or c) TAU alone. The primary outcome was a within-individual change in PHQ-9 score between baseline and 8 weeks. Secondary outcomes were 1) response, 2) remission, and 3) functional impairment at 8 weeks, plus 4) change in PHQ-9 at 6 months. Of the randomized patients, 100 (71.4%) completed treatments, including 29/45 (64.4%) patients in the BA group, 39/49 (79.6%) in the PS group, and 32/46 (69.6%) in the TAU group. By 8 weeks, PHQ-9 scores declined most in the TAU group [BA -0.28 (95% CI -2.48, 1.92), PS -0.58 (-2.09, 0.94) vs. TAU -3.32 (-5.21, -1.44); group-difference test, p = 0.034]. The secondary outcomes in the BA or PS arms did not significantly differ from those in TAU. Videotaped sessions revealed marked variation in briefly trained therapists' adherence to the treatment manual. In this randomized trial, the effectiveness of treatments with the added BA and PS groups did not exceed that of TAU alone. The preconditions in which brief BA or PS group interventions benefit outpatients with depression in psychiatric settings warrant critical investigation.

Fabrication and characterization of β-TCP/Zn-1Mg composite scaffolds for orthopedic applications

Bone tissue defects have emerged as a significant health concern, impacting individuals' overall well-being and daily functionality. The implantation of scaffold materials for bone repair is crucial to structurally replace the damaged bone area, providing essential mechanical support and fulfilling other functional requirements. In this study, in order to develop bone repair scaffold materials with enhanced mechanical properties, moderate corrosion behavior, favorable cytocompatibility, and notable antibacterial activity, xβ-TCP/Zn-1Mg composite scaffolds with varying β-TCP concentrations (x = 0, 0.5, 1, 3) were fabricated using an atmospheric pressure infiltration molding method. The resulting scaffolds featured interconnected and uniformly distributed pores, with an average pore size of approximately 250 μm and a porosity of around 60 %. The xβ-TCP/Zn-1Mg composite scaffolds exhibited a plateau stress ranging from 13.22 to 16.89 MPa and an elastic modulus between 0.62 and 0.82 GPa, closely resembling the mechanical properties of human cancellous bone. The incorporation of β-TCP accelerated the degradation process and promoted calcium phosphate deposition on the specimen's surface. Additionally, the β-TCP/Zn-1Mg composite scaffolds demonstrated significant antibacterial activity against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Furthermore, 2-fold diluted extracts derived from xβ-TCP/Zn-1Mg composite scaffolds were found to enhance the proliferation of MC3T3-E1 pre-osteoblast cells, indicating good cytocompatibility. Therefore, the xβ-TCP/Zn-1Mg scaffold materials hold promise as a compelling candidate for orthopedic applications.

Nickel‐ and Palladium‐Catalyzed Copolymerizations of Norbornene with Polar α‐Olefins

AbstractRecent progress regarding the copolymerization of norbornene with various polar α‐olefins catalyzed by nickel and palladium catalysts is reviewed here with special attention paid to the diverse catalyst frameworks, polar monomer scopes as well as polymer microstructures. Both the influences of steric effect and electron property of ligand substituents and the type of polar monomers on the catalytic behaviors (activity, stability, polarity tolerance, etc.) and the polymer microstructures (molecular weight and distribution, comonomer contents, etc.) have been summarized. The introduction of noncyclic‐olefins, such as polar vinyl monomers, polar higher α‐olefins, and polar styrenes, into rigid cyclic‐based polynorbornene chain resulted in significant modifications on the polarity, compatibility, thermostability, processibility, transparency, and many other properties of the material, which has also been discussed in the review. The contents of this review have been classified according to the type of polar monomers involved in the norbornene copolymerization, and each section included nickel and palladium catalysts bearing different ligand structures, which will be meaningful for the development of new types of catalysts and new families of norbornene‐based cyclic olefin copolymer materials in the future.

Feasibility and acceptability of a community health worker administered behavioral activation intervention for postpartum depression: a single arm pilot study from India.

Women in India experience high rates of postpartum depression (PPD), with minimal availability of screening or treatment. India has an extensive network of community health workers, known as accredited social health activists (ASHAs). While they are knowledgeable about most maternal-child health problems, they have minimal knowledge about PPD. We trained ASHAs to deliver a simple home-based intervention, behavioral activation (BA), which involves individuals in activities that are sources of positive reinforcement to counter depression. The research questions guiding this study were as follows: 1) What are the feasibility and acceptability of ASHAs screening for and delivering a brief behavioral activation intervention addressing PPD among women in Belagavi, South India? 2) What impact did the brief behavioral activation intervention have on PPD? The mixed methods evaluation used interviews with participants and interventionists, and depression scores were assessed before and after the evaluation. After a 2-day training with 17 ASHAs that focused on understanding PPD, screening using the Edinburgh Postnatal Depression Scale (EPDS), and implementing the BA protocol, ASHAs and researcher supervisors screened the mothers 6-12 weeks postpartum presenting at pediatric immunization clinics. Mothers who screened positive were invited to participate in an ASHA-led 5-week BA intervention, with ASHAs visiting the mothers' homes. We assessed post-intervention EPDS scores and conducted satisfaction assessments and individual interviews. All 26 women who screened positive on the EPDS agreed to be enrolled in the study. All participants had a significant reduction (p < 0.001) in PPD scores. Both ASHAs and mothers had high enthusiasm for the intervention methods and activities. This ASHA-delivered BA intervention was found to be feasible, acceptable, and effective in treating PPD in rural Indian mothers. This corroborates literature that demonstrates the efficacy of a BA intervention among individuals with generalized depression in South Asia. In communities with minimal mental health resources, interventions led by trained community workers have the potential to address PPD.

Promoting Awareness of Sedentary Behavior and Physical Activity Awareness Among Rural Youth Through Bocce Game: A Qualitative Study

In youth, it is important to promote physical activity habits. The multifactorial nature of rural areas affects individuals' physical activity habits, and sustainable strategies are needed to promote sedentary behavior and physical activity awareness among rural youth. The research data consists of qualitative interviews with healthy rural youth after the bocce game activity. In-depth interviews were conducted with 11 volunteers who participated in the activity using a semi-structured interview form. Qualitative findings are divided into nine main themes: Thoughts on bocce game activity; meaning of physical activity and thoughts on the topic; physical activity and its effect on health; thoughts on the frequency, duration, intensity, and type of physical activity; meaning of sedentary behavior and thoughts on the topic; sedentary behavior and its effect on health; thoughts on the frequency and duration of sedentary time and the type of sedentary behavior; promoting awareness of sedentary behavior and physical activity through bocce game; expectations from institutions. The findings highlight that bocce is a vital strategy to encourage physical activity and sedentary behavior awareness among youth in rural areas. Local authorities have a critical role in supporting physical activity and sedentary behavior awareness in rural areas.

Indicators of Dietary Behavior and Physical Activity Change Associated with Metabolic Control of Obesity, Hypertension, and Type 2 Diabetes Mellitus in Mexican Adults: National Nutrition and Health Survey in Mexico, 2016.

Introduction: Obesity (OB), type 2 diabetes mellitus (T2D), and hypertension (HTN) are health issues in Mexico linked to unhealthy behaviors. This study investigates the relationship between behavior change indicators and metabolic control in Mexican adults with OB, T2D, and HTN. Methods: We used data from the 2016 National Health and Nutrition Survey Midway (ENSANUT MC-2016), representing ∼59.5 million Mexican adults aged 20-59 with these conditions. We assessed behavior change indicators, including stages of change, self-efficacy, and perceptions of benefits and barriers. In addition, we conducted descriptive analyses and used statistical tests, such as Pearson's chi-squared test and logistic regression models, adjusted for multiple variables. Results: We found that adults in the action and maintenance stages of physical activity (PA) were four times more likely to have adequate HTN control than those in the precontemplation stage. Self-efficacy for PA was related to better control in T2D and HTN. Self-efficacy for reducing the consumption of sugary beverages was positively associated with control in OB and T2D. No significant association was observed with self-efficacy for consuming fruits and vegetables. Conclusion: Behavior-change indicators are significantly linked to metabolic control in adults with HTN. These results support the importance of these indicators in managing chronic diseases such as HTN and their potential use in public health strategies.

Physical activity and sedentary behavior levels among individuals with mental illness: A cross-sectional study from 23 countries.

People with mental illness tend to present low levels of physical activity and high levels of sedentary behavior. The study aims to compare these levels in mental illness patients, exploring the role of socioeconomic development and treatment setting. This cross-sectional study used accelerometers and the Simple Physical Activity Questionnaire (SIMPAQ) to assess physical activity and sedentary behavior in mental illness individuals living in 23 countries. Two-way ANOVAs were used to evaluate the interaction between socioeconomic development and the treatment settings on physical activity and sedentary behavior. A total of 884 (men = 55.3%) participants, mean age of 39.3 (SD = 12.8), were evaluated. A significant interaction between socioeconomic development and treatment settings was found in sedentary behavior (F = 5.525; p = 0.019; η2p = 0.009; small effect size). Main effects were observed on socioeconomic development (F = 43.004; p < 0.001; η2p = 0.066; medium effect size) and treatment setting (F = 23.001; p < 0.001; η2p = 0.036; small effect size) for sedentary behavior and physical activity: socioeconomic development (F = 20.888; p < 0.001; η2p = 0.033; small effect size) and treatment setting (F = 30.358; p < 0.001; η2p = 0.047; small effect size), showing that HIC patients were more active, while MIC patients were more sedentary. Moreover, despite of inpatients had presented higher levels of physical activity than outpatients, they also spent more time sitting. Socioeconomic development plays an important role in sedentary behavior in patients with mental disorders, warning the need to develop new strategies to reduce these levels in this population.

Behavioral activation for depression in groups embedded in psychosomatic rehabilitation inpatient treatment: a quasi-randomized controlled study.

Behavioral activation (BA) and cognitive-behavioral therapy (CBT) have shown to be efficacious treatment methods for depression. Previous studies focused mostly on the outpatient treatment either in group or individual setting. The present study aimed at comparing the efficacy of group treatment BA vs. CBT, when embedded in inpatient psychosomatic rehabilitation treatment. 375 inpatients were randomly assigned to either BA (N = 174) or CBT (N = 201). We used established scales for depression such as the Beck Depression Inventory II (BDI-II, self-rating), the Quick Inventory of Depressive Symptomatology (QIDS; expert rating) and the Behavioral Activation for Depression Scale (BADS) to assess changes over the course of the treatment and at follow-up (4 to 6 months). In addition, we measured disability-related functioning with the Mini-ICF-APP, a rating scale built in reference to the International Classification of Functioning, Disability and Health (ICF). Multilevel models with repeated measures were conducted to examine the differences between groups in relation to change over time with patients' random effects. Both group formats showed substantial reduction in depressive symptoms at the end of treatment (d= 0.83 BA vs. d= 1.08 CBT; BDI-II) and at follow-up after 4 to 6 months (d = 0.97 BA vs. d = 1.33 CBT, BDI-II; and d = 1.17 BA vs. d = 1.09 CBT, QIDS). There were no significant differences between treatment approaches. At least 50% symptom reduction was achieved by 53.7% and 54.2% in BA vs. CBT respectively. Reported activation levels increased from pre- to posttreatment (d = 0.76 BA vs. d = 0.70CBT), while showing loss of increment between the end of the treatment until follow up in both formats (d = 0.28 BA vs. d = 0.29 CBT). Both modalities led to significant improvement of symptomatology and functioning at the end of the treatment and at follow-up, thus for the first time demonstrating the practicability of BA in rehabilitation clinics. Considering its lower requirements regarding cognitive abilities and its easier implementation, BA proved to be a good alternative to other psychotherapeutic treatments.

Influence of Laser Treatment of Ti6Al4V on the Behavior of Biological Cells.

This article explores the enhancement of material surface properties of Ti6Al4V, potentially applicable to dental implants, through ultra-short pulse laser systems. This study investigates potential connections between surface wettability and biocompatibility, addressing the challenge of improving variability in material properties with specific laser treatment. Several designed microstructures were manufactured using a picosecond laser system. After that, the wettability of these structures was measured using the sessile drop method. The basic behavior and growth activity of biological cells (MG-63 cell line) on treated surfaces were also analyzed. While the conducted tests did not conclusively establish correlations between wettability and biocompatibility, the results indicated that laser treatment of Ti6Al4V could effectively enlarge the active surface to better biological cell colonization and adhesion and provide a focused moving orientation. This outcome suggests the potential application of laser treatment in producing special dental implants to mitigate the issues during and following implantation.

Synergism between two BLA-to-BNST pathways for appropriate expression of anxiety-like behaviors in male mice

Understanding how distinct functional circuits are coordinated to fine-tune mood and behavior is of fundamental importance. Here, we observe that within the dense projections from basolateral amygdala (BLA) to bed nucleus of stria terminalis (BNST), there are two functionally opposing pathways orchestrated to enable contextually appropriate expression of anxiety-like behaviors in male mice. Specifically, the anterior BLA neurons predominantly innervate the anterodorsal BNST (adBNST), while their posterior counterparts send massive fibers to oval BNST (ovBNST) with moderate to adBNST. Optogenetic activation of the anterior and posterior BLA inputs oppositely regulated the activity of adBNST neurons and anxiety-like behaviors, via disengaging and engaging the inhibitory ovBNST-to-adBNST microcircuit, respectively. Importantly, the two pathways exhibited synchronized but opposite responses to both anxiolytic and anxiogenic stimuli, partially due to their mutual inhibition within BLA and the different inputs they receive. These findings reveal synergistic interactions between two BLA-to-BNST pathways for appropriate anxiety expression with ongoing environmental demands.