Source: Davidson AJ, Huang GH, Czarnecki C, et al. Awareness during anesthesia in children: a prospective cohort study. Anesth Analg. 2005;100:653–661.Investigators from The Royal Children’s Hospital in Melbourne, Australia carried out a prospective cohort study to assess the incidence and nature of awareness during anesthesia in children. This study was “nested” in a larger study of behavioral changes in children after hospitalization and anesthesia. Patients ages 5 to 12 years having general anesthesia for any procedure were eligible for the study. Study children were randomly enrolled from each day’s operating room schedule. The type of general anesthesia provided was not controlled. Following anesthesia, enrolled subjects were asked a set of screening questions at 3 different times; the first or second day, the third day, and finally the 30th day post-anesthesia. Behavior changes were assessed at 30 days post-anesthesia. One of the principal investigators interviewed all cases of possible awareness and generated a case report. The reports were reviewed by 4 pediatric anesthesiologists from outside locations and classified as “awareness,” “possible awareness,” or “not awareness.”Eight-hundred-sixty-four children were interviewed using questions such as “Did you have any dreams or feel or hear anything while you were having the operation?” There were 28 cases of suspected awareness based on the screening questionnaire. At least 1 of the 4 outside reviewers felt that 12 of these 28 reports represented “awareness.” Seven of the 12 cases had a unanimous consensus of “awareness” by all 4 reviewers, giving an incidence of awareness of at least 0.8% (95% CI, 0.3 to 1.7%). Five of these children reported pain, classified as “mild” in 4, and “moderate” in 1. No child reported being upset at the time of the interview. One of 5 of the “aware” children had a significant deterioration in behavior. This was not significantly different from the 15.8% incidence of behavior deterioration in the “non-aware” group. The authors were unable to demonstrate a statistically significant difference between the “aware” and “non-aware” groups in the use of sedative premedication, type or length of anesthesia, use of muscle relaxants, age, or incidence of critical events.Dr. Valley has disclosed no financial relationships relevant to this commentary.The authors demonstrated an incidence of awareness (0.8%) in a cohort of pediatric patients who were relatively healthy and undergoing elective surgery; that percent-age is considerably higher than that quoted for adults (0.1 to 0.2%).1 Only 1 of the “aware” subjects received muscle relaxants. As the authors discussed, higher anesthetic requirements (minimum alveolar anesthetic concentration [MAC]) and differences in the pharmacology of intravenous anesthetics may partially account for a higher incidence of awareness in children.2,3 An interesting clinical practice by the anesthesiologists at the study site may also explain some of the cases of awareness. After induction of anesthesia in an “Induction Room,” the patient was disconnected from the anesthesia circuit and transported a short distance to the operating room where the patient was then reconnected to an anesthesia circuit and inhalation anesthesia resumed or started. Six of the 7 “aware” subjects had an inhalation (versus intravenous) induction. Hence, it is possible that some “lightening” of anesthetic depth occurred during this time. The authors acknowledge that this could have been a factor in 5 of the 7 reported cases of awareness.This article comes on the heels of a “Sentinel Event Alert” sent out by JCAHO in October 2004,4 which alerted anesthesia providers to the problem of awareness during anesthesia and suggested how it could be prevented and managed. The Society for Pediatric Anesthesia, the AAP section on Anesthesiology and Pain Medicine, and the ASA Pediatric Anesthesia Committee took issue with some of the recommendations and sent a joint letter to JCAHO asking that the alert be withdrawn. The letter noted the paucity of data on the use of “awareness monitors” for pediatric patients, cited evidence that in some situations these devices can be misleading, and expressed concern about the recommendations on the use or avoidance of certain anesthetic agents and muscle relaxants.Awareness during anesthesia can and does occur in children. Clinicians and researchers are now charged with developing sound clinical guidelines to prevent, detect, and deal with cases of awareness in children.Knowledge of this problem may result in better awareness on the part of anesthesiologists both in transferring children receiving inhaled anesthesia from an “induction room” to an operating room, and in the OR.
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