In this paper, by applying historical methods and the pedagogical documentation analysis, we examine the humanitarian and general educational role of the Female community of Niš and its trade school since its establishment until the beginning of World War II. The community of Niš was established after the liberation from the Turks at the beginning of 1879, as a branch of the Female community of Belgrade. The communities represented humanitarian organizations that took care of the protection of women and their rights to enlightenment, and were directly involved in the establishment and operation of the Women's Trade school of Niš (founded in 1883). Women were more able to bond, to make lingerie and dresses during education. Despite the minimal representation of general subjects, the Female community of Niš and its trade school enabled organized institutional education of members, meaning women, through their active humanitarian and general educational operation. The female students who finished this school, were able to perform handicraft work and thus got the opportunity to, actively along with men, participate in the social life of Serbia in the first half of the twentieth century.