Opalinus Clay, a Mesozoic clay shale, has been chosen as host rock formation for the disposal of radioactive waste in Switzerland. For this study, borehole damage zones were utilized as a proxy for an excavation damage zone that forms around a circular, mechanically excavated tunnel in intact Opalinus Clay. Pilot boreholes were resin-impregnated and over-cored at different times after drilling, to provide insight into the time-dependent formation of fractures on both the micro- and the macro-scale. Observed fractures were characterized in terms of failure mode, their relation to the rock anisotropy, and the in-situ stress tensor.The analyses show that fractures that form in the short term initiate as shear fractures at the pilot-borehole wall and propagate parallel to bedding. Typically, a dominant shear fracture tangential to the pilot borehole wall was observed. Upon propagation of these shear fractures, wing cracks, horsetail splays and second-order shears form sub-parallel and sub-perpendicular to bedding planes, forming a complex fracture network, which extends a quarter pilot-borehole diameter into the rock mass. In the longer term, tangential shear fractures tend to propagate in a direction opposite to the initial propagation direction. In addition, new bedding-parallel fractures deeper in the rock develop, leading to the formation of thin slabs, buckling of the slabs when unsupported and eventually progression of the buckling zone deeper into the rock mass. Buckling is associated with the formation of extensional fractures normal to bedding in the center and lateral to the buckling zone. The zone of buckled rock slabs was found to have an extension of more than one borehole diameter at the time of preservation with resin.In the short term, the axis connecting the maximum failure depth on opposing sides of the borehole is parallel to the minimum stress direction in a plane normal to the borehole axis. In the long term, this axis rotates significantly towards the maximum stress direction, primarily as a consequence of tangential shear fracture propagation, slab formation and buckling. Dissipation of excess pore pressures may be the key process underpinning longer-term fracture propagation and formation.