Objective: Isotretinoin is highly preferred in the treatment of severe and resistant acne, but there are still disagreements about whether it has psychogenic side effects. In this study; we aim to investigate the changes in psychological symptoms before and after the treatment in a group of patients treated with isotretinoin. Material and Methods: A total of 110 patients who had moderate or severe acne, and decided to start isotretinoin treatment, were included. Acne Quality of Life Scale, Beck Depression Inventory (BDI), Beck Suicidal Ideation Scale, and Symptom Check List (SCL-90-R) Psychological Symptom Screening tests were performed and compared before starting treatment and at the 6th month of treatment. Results: In our study, in both the pre-treatment and post-treatment groups, the rate of patients at risk for depression was significantly higher in the group that had severe acne (p<0.05). The scores of psychiatric tests with moderate acne were found to be significantly lower than those with severe acne in all parameters (p<0.05). We have found that somatization, depression, phobic thoughts, and general symptom index scores were significantly higher in women before and after the treatment (p<0.05). Acne treatment was associated with improved quality of life and BDI scores in both male and female patients (p=0.001). SCL-90-R somatization, obsession, depression, sensitivity, anger, and general symptom index scores decreased significantly after the treatment. Conclusion: Our study objectively demonstrated that isotretinoin treatment does not cause depression and psychological symptoms, and even improves depression and psychological symptoms caused by acne and improves the quality of life.
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