Monte Carlo codes are veritable tools in radiotherapy to understand the transport mechanism, dose distributions, and energy depositions of ionizing radiations traversing in different media. In some beam calibration protocols, a tissue-phantom-ratio at depths 20 cm and 10 cm (TPR20,10) in a phantom is used to determine the beam-quality conversion factor for different ion chambers. Thus, this study aims to evaluate the efficiency of Monte Carlo code in the determination of beam quality of high radiation energy beams similar to what is expected in clinical settings. Electron Gamma Shower National Research Council in Canada (EGSnrc) Monte Carlo Code was used to design complex ion chamber geometries according to the manufacturer’s specifications. Phase space files were used as x-ray beam radiation sources. Two set-ups (SAD and SSD) methods were used for the determination of TPR20,10 to conform to the accepted clinical procedures. Beam collimation was 10 cm by 10 cm field size with an ionization chamber placed at 20 cm and 10 cm in the water phantom to obtain doses at two points respectively. The TPR20,10 of each energy was obtained using the appropriate equations. The obtained results showed no significant difference between the measured and available TPR 20,10 data (p = 0.995). Ion chamber configurations and specifications were also found not to have a significant effect (p = 0.33) on the TPR 20,10 obtained values. The results obtained in this study are in agreement with the recommended standard values. The findings of this study show that the Monte Carlo codes can be used as a tool in determining x-ray beam quality indices of designed clinical linear accelerator (Linac) machines.