Relevance. The "state-science-business" model has firmly entered the practical sphere of human and social life as a signifier of many socio-economic processes. It is a systematic integrated approach to the consideration of problems exclusively applied areas that will allow them to be solved in the most effective way and in the shortest possible time. The economic sphere has always been considered by the state as one of the priorities, since a steadily developing economy provides ample opportunities for the development of civil society. Over the past few years, the President and the Government of Russia have outlined clear guidelines for the development of the economy, one of which is the modernization of the industrial complex of the state through the inclusion of the state and scientific and technological block in the industrial system. The purpose of this study is to review and analyze the model of interaction "state – science – business" within the framework of Russia's economic development and the long-term plans established by the President of the Russian Federation concerning the modernization of the industrial complex. Objectives: to analyze the international experience of the development of the industrial complex; to consider the features of the formation and functioning of the domestic industrial complex; to study the current state and assess the prospects for the development of the economy and production on the example of the military-industrial complex of Russia. Methodology. The study was carried out on the basis of the general provisions of the system theory and interinstitutional and transinstitutional communication using the system-structural method. Results. In the conditions of the established priorities of economic development at the highest level, it is necessary to: develop internal and external R&D; generate the creation of a new type of university, the ecosystem of which moderates ideas and projects requested by society and the state, releasing them into the real sector of the economy for production and economic development; introduce the university (science) into the business community; form engineering andscientific personnel potential. Conclusions. For the economic development of the country, it is necessary to strengthen the "state-science-business" relationships not only from the perspective of the industrial complex, but also scientific and educational platforms, including through the development of external R&D and their opening on the basis of higher educational institutions.