This paper explores the cooperative control of unmanned surface vessels (USVs) and unmanned aerial vehicles (UAVs) in maritime rescue and coastal surveillance. The USV-UAV system faces challenges of disturbances and substantial inertia-induced overshooting during path following. A novel position prediction line of sight (LOS) guidance law is proposed to address these issues for USV path following control. Radial basis function-based neural networks (RBF-NNs) are used to estimate disturbances, and a high-order differentiator is used to design a velocity observer for unknown USV velocity. The UAV control system employs proportional–derivative (PD) control with feedforward compensation for quadrotor control design and utilizes a finite-time converging third-order differentiator to differentiate non-continuous functions. The simulation results demonstrate strong robustness in the proposed USV-UAV cooperative control algorithm. It achieves path following control in the presence of wind and wave disturbances and exhibits minimal overshoot.