The monthly, seasonal, annual, and decadal trends of seven hydro-meteorological variables were analysed for stations in Akwa Ibom State, Nigeria, controlled by the Nigerian Meteorological Agency (NiMet) and the Cross River Basin Development Authority (CRBDA) from 1972 to 2021. At the 5% statistical significance level, the non-parametric Mann-Kendall and Sen's slope estimator techniques were used to detect if there was a positive or negative trend and the magnitude of the trend in hydro-meteorological data. In the present study, there was a significant statistically increasing (positive) trend in mean seasonal and annual rainfall, maximum temperature, minimum temperature, and runoff. However, there was a significant statistically decreasing (negative) trend in average annual relative humidity, solar radiation, and potential evapotranspiration. The magnitudes of the trends were 19.39mm/year, 0.0314oC/year, 0.013oC/year, -0.104%/year, -8.78MJ/m2/year, -1.440mm/year, and 0.028m3/s/year for annual rainfall, maximum temperature, minimum temperature, relative humidity, solar radiation, PET, and runoff, respectively. The rising trends in precipitation, temperature, and runoff in this research area show that this region is subject to climatic variability. The results of the Mann-Kendall and Sen's slope estimator statistical tests revealed the consistency of performance in the detection of the trend for the hydro-meteorological variables.