Basic Immunization Research Articles

HUBUNGAN IMUNISASI RUTIN LENGKAP TERHADAP PERTUMBUHAN DAN PERKEMBANGAN ANAK USIA 36-59 BULAN DI INDONESIA (ANALISIS DATA RISKESDAS TAHUN 2018)

WHO reports that 28.7% of children under five experience impaired growth and development in Southeast Asia. In Indonesia, the complete basic immunization coverage has not reached the target. It is 57.9%. This study aims to analyze the relationship of complete routine immunization with the growth and development of children in Indonesia. The method of data analysis uses a complex sample survey from Riskesdas 2018 with a cross sectional research design. Sampling used multistage random sampling with a sample of 10462 respondents. The results showed that the prevalence of children with abnormal growth was 27.1% and doubtful development was 39.9%. The results of multivariate analysis showed that there was no significant relationship between complete routine immunization and child growth (p value = 0.266; PR = 1.088; 95%CI = 0.9381.261) after controlling by variable sex and there was no significant relationship between complete routine immunization with child development (p value = 0.131; PR = 1.110; 95%CI = 0.969 -1.271) after controlling by variable access to health care facilities. Parents should provide complete routine immunizations, give an adequate food intake, maintain a clean environment and routinely bring children to the posyandu to monitor children's growth and development.

Study of three kinds of primary immunization schedules with poliovirus vaccine

Objective: To compare the immunogenicity of three kinds immunization programs with poliovirus vaccine. Methods: Healthy infants aged 2 months or over were selected and divided into three groups by complete randomization method. Basic immunization with Sabin inactivated poliovirus vaccine(sIPV) and bivalent oral poliovirus vaccine(bOPV) were completed. Three kinds of basic immunization procedures were 1sIPV+2bOPV,2sIPV+1bOPV and 3sIPV, respectively.Two qualified serums that before basic immunization and 28-42 days later were collected, and measured the poliovirus neutralizing antibody with microcell neutralization method. To compare the difference by analysis of variance, rank test and χ2 test. Results: After the basic immunization, 205 subjects of the positive conversion rate of poliovirus neutralizing antibodies of types Ⅰ, Ⅱ and Ⅲwere all higher than 97.00%, and the positive rates were all higher than 98.00%, the geometric mean titer (GMT) of neutralizing antibody was significantly higher than that before basic immunization in three groups.There were significant differences in the positive rate and GMT before and after basic immunization of typeⅠ, Ⅱand Ⅲ in the three (P<0.05). The highest GMT in three groups after basic immunization were all typeⅠ, followed by type Ⅲ, and the lowest in type Ⅱ. The GMT of type Ⅱin 2sIPV+1bOPV and 3sIPV groups were both higher than that in sIPV+2bOPV group. Conclution: After three kinds of basic immunization, the poliovirus neutralizing antibodies of serum were all at high levels in three groups, which could form an effective immune barrier against poliovirus. The immunogenicity of three kinds of basic immunization programs were all well, but there were certain differences of neutralizing antibodies among three kinds basic immunization programs. The immunogenicity in 2sIPV+1bOPV and 3sIPV groups against typeⅡpoliovirus were better than that in 1sIPV+2bOPV group.

Serological Response to Three, Four and Five Doses of SARS-CoV-2 Vaccine in Kidney Transplant Recipients.

Mortality from COVID-19 among kidney transplant recipients (KTR) is high, and their response to three vaccinations against SARS-CoV-2 is strongly impaired. We retrospectively analyzed the serological response of up to five doses of the SARS-CoV-2 vaccine in KTR from 27 December 2020 until 31 December 2021. Particularly, the influence of the different dose adjustment regimens for mycophenolic acid (MPA) on serological response to fourth vaccination was analyzed. In total, 4277 vaccinations against SARS-CoV-2 in 1478 patients were analyzed. Serological response was 19.5% after 1203 basic immunizations, and increased to 29.4%, 55.6%, and 57.5% in response to 603 third, 250 fourth, and 40 fifth vaccinations, resulting in a cumulative response rate of 88.7%. In patients with calcineurin inhibitor and MPA maintenance immunosuppression, pausing MPA and adding 5 mg prednisolone equivalent before the fourth vaccination increased the serological response rate to 75% in comparison to the no dose adjustment (52%) or dose reduction (46%). Belatacept-treated patients had a response rate of 8.7% (4/46) after three vaccinations and 12.5% (3/25) after four vaccinations. Except for belatacept-treated patients, repeated SARS-CoV-2 vaccination of up to five times effectively induces serological response in kidney transplant recipients. It can be enhanced by pausing MPA at the time of vaccination.

Completeness Basic Infants Immunization To Achieve Universal Child Immunization At The Public Health Center Semparuk Sambas West Kalimantan In 2021

Completeness of immunization is something that is already complete, while is an effort to provide immunity to infants and children by incorporating BCG, Hepatitis, Polio, DPT, Measles vaccines into the body so that the body makes antibodies to prevent disease. The factors of completeness of immunization are knowledge, attitudes, availability of facilities and infrastructure, affordablity of distance, the role of posyandu cadres, the role of health workers and the role of the husband. The purpose of this study was to determine the factors that most influence the completeness of basic immunization for infants at the Semparuk Sambas public health center. This research is quantitative with a cross sectional approach. The population in this study were all mothers who had babies age 9-12 months as many as 129 mothers. Sampling technique by means of total sampling. Analyze using multiple logistic regression test using SPSS 16.0. The results of the study that the completeness of immunization in infants was 69%. The results of logistic regression showed that there was a ralitonship between education, work, attitudes, the role of posyandu cadres, the role of health workers and the role of the husband. Attitude is the most dominant variabel with an OR 3,444. Its hoped that the more positive the mother attitude will tend to pay attention to the schedule of giving immunization to her baby, the positive mother attitude will be better in giving the perception of something she knows.Keyword: immunization equipment, attitude, the role of health workers

PENGARUH KELENGKAPAN IMUNISASI DASAR TERHADAP TUMBUH KEMBANG BAYI (0-1 TAHUN) YANG LAHIR PADA MASA PANDEMI COVID-19

Abstract : Basic immunization is one of the infectious disease prevention programs for children. Basic immunizations given in full will affect the stage of growth and development in children. Normal growth and development in accordance with his age is very good for the continuation of life in the future. The Covid-19 pandemic limits us from doing activities outside the home and has an impact on the continuity of health services, one of which is a decrease in basic immunization visits. The purpose of this study was to determine the effect of completeness of basic immunization on the growth and development of infants (0-1 years) born during the Covid-19 pandemic. The research method used is an analytical observational research design with a cross sectional approach. The research was conducted at BPM Bd. Elviana. The respondents used were infants (0-1 years) who were born during the Covid-19 pandemic. The results of the study show that there is a relationship between the completeness of immunization and the growth of babies born during the Covid-19 pandemic with a p value = 0.012 &lt; 0.05. And there is no relationship between completeness of immunization and the development of babies born during the Covid-19 pandemic with p value = 0.066 &gt; 0.05Keywords : Basic Immunization, growth, development, baby, covid-19

Trends, projection and inequalities in full immunization coverage in Ethiopia: in the period 2000-2019

BackgroundImmunization is among the most cost-effective health interventions to improve child survival. However, many countries in sub-Saharan Africa failed to achieve their national and international coverage targets repeatedly. The present study investigated trends of coverage and inequalities in coverage in Ethiopia.MethodsThis study used data from five rounds of the Demographic and Health Surveys conducted in Ethiopia in 2000, 2005, 2011, 2016, and 2019. The surveys used a multistage cluster sampling procedure to obtain a nationally and sub-nationally representative data. The outcome variables included in the study were full immunization coverage and inequality. The World Health Organization’s Health Equity Assessment Toolkit was used to conduct the inequality analysis. Projections for 2025 were based on smoothed averages generated using the demographic and health survey data from 2000 to 2019.ResultsThe full (basic) immunization coverage in Ethiopia has increased steadily from 14.3% in 2000 to 44.1% in 2019. Based on the average past performance, the immunization coverage is projected to reach 53.6% by 2025, which will be short of the 75% national full (basic) immunization coverage target for the year 2025. Mothers with higher levels of education are more likely to get their children all basic vaccinations than those with lower levels of education. Similarly, the inequality gaps due to wealth and residency are significant; where children in the lowest wealth strata and those living in rural areas remained disadvantaged.ConclusionDespite a steady increase in immunization coverage in the past two decades the country is yet to achieve its immunization target. Thus, more efforts are needed to achieve the current and future national immunization targets. A more focused intervention targeting the disadvantaged groups could be an effective strategy to achieve coverage and minimize the inequality gaps in immunization.

Relationship Between Knowledge and Parctice of Mothers With Basic Immunization Completeness in Infant Aged 0-12

Background: Based on the Health Profile of Kediri Regency, immunization coverage in 2015, Kediri Regency has not reached the predetermined terget because the coverage is still below 90%. According to the reporting that has been collected in the Kediri District Health Profile, the Papar District is one of the three sub district that has the lowest proportion of immunization coverage, which is below 80%. Aim: This study is conducted to determine the relation between mothers’ knowledge and practices and basic immunization completeness coverage on babies aged 0-12 months in Papar District Health Center, Kediri Regency. Method: This study uses observational analytical study with cross sectional approach. The population were all mothers who have babies aged 0-12 months in the Papar District, Kediri Regency, amounting to 416. Moreover, this study uses total sampling technique to gather the data. The instrument used for this study cinsisted of two questionnaires, a questionnaire for knowledge and practice. Results: The sample size was 150 respondents with the inclusion criteria including mothers that have babies aged 0-12 months, are at the location at the time of this study, and are willing to be respondents. Meanwhile, the exclusion criteria are mothers who do not have MCH Handbook (Kartu Ibu dan Anak/KIA) or growth chart (Kartu Menuju Sehat/KMS) and mothers who are out of town when the data collection is conducted. It is shown that 48% of mothers have good knowledge, 93.3% of mothers have good practices towards immunization, and 92% of infants had complete immunization coverage. The results of the Chi-square test of knowledge on immunization completeness coverage p = 0.527 (p&gt;0.05), practice on immunization completeness coverage p = 0.001 (p &lt;0.05). Conclusion: The data shows that there is no relationship between knowledge and immunization completeness coverage. Meanwhile, it is found that there is a relationship between practice and immunization completeness coverage in Papar District Health Center, Kediri Regency.

Inovasi Kebijakan Pengembangan Kota Layak Anak Tangerang Selatan

This study aims to determine the Development of South Tangerang City Government (Tangsel) Policy implementing the Ministerial Regulation of Women's Empowerment and Child Protection of the Republic of Indonesia Number 11 of 2011 concerning Child Friendly City Development Policies. The research uses a descriptive qualitative approach, which explains the phenomenon in depth through data collection. This descriptive research provides an accurate and objective description and explanation of the actual state of the object under study. The theory used is the theory of public policy making according to Metter and Horn. The results showed that the development of South Tangerang Child Friendly City in general went well. Among them are shown by the achievement of basic health and welfare, the large number of breastfeeding facilities, the high percentage of complete basic immunization for children, the low prevalence of malnutrition in children under five, the low infant mortality rate (IMR), and the active and successful Adolescent Reproductive Health Counseling Information Center.

Sosialisasi Pentingnya Aplikasi Reminder Jadwal Imunisasi di Puskesmas X Kota Padang

The Ministry of Health and UNICEF survey of more than 5,300 health facilities in Indonesia showed that 84% of children's immunization services were disrupted due to the Covid-19 pandemic. Regular reports from the Padang City Health Office As of February 2021 the average achievement of Complete Basic Immunization only reached 62.6% with a target of 95%, even though the immunization program was provided free of charge by the government at the Puskesmas and Posyandu. This community service facilitates health workers and cadres in disseminating information related to child immunization schedules and other health information. The Service Method is a mixed method by observing problems and designing needs and having webinars using zoom meetings. The result of the service activity is the design of the SMS Gateway-based Smart Immunization system to be one that can remind parents and make it easier for officers to record reporting, as well as an evaluation for policy makers in monitoring immunization achievements every month. The design of the application is also worthy of being developed by integrating with other applications such as WhatsApp, Telegram, and Email. From the results of this service, it is hoped that it can be used as input and consideration in making an immunization schedule reminder application and disseminating other health information for parents and the community Keywords: Immunization, Information, Reminder, Covid-19, Padang City

Relationship of the Motivation of the Midwife and the Mother's Compliance with Complete Basic Immunization in the Hana Kasih Clinic

Health problems, especially in children, are the occurrence of several infectious diseases such as Measles, Diphtheria, Pertussis, Tetanus Neonatorum, Tuberculosis, Hepatitis B and Polio which can cause death or disability in children. There are still many mothers who do not take their children to health facilities to get complete basic immunizations. The role of midwives in providing motivation to families, especially mothers about immunization status, is thought to be able to increase maternal compliance to increase the coverage and completeness of basic infant immunization. The research method uses analytic with a cross sectional approach. The population in this study were 112 people and a sample of 53 people. The results showed that the motivation of the midwives according to mostly good was 54.7%, which stated that it was less than 45.3%. Mother's adherence to complete basic immunization for infants in the obedient category was 73.6%, those who did not comply were 26.4%. The motivation of the midwife is related to maternal compliance with complete basic immunization for infants at the Hana Kasih Clinic in 2021, p-value of 0.000 &lt;0.05. It is hoped that midwives will motivate mothers, especially mothers who have babies, to immunize their babies with the 5 (five) basic immunizations required by the government.

The Correlation of Education, Work, and Mother's Age with The Completeness of Basic Immunization in Toddlers at Puskesmas Kuok-Riau in Period of January-June 2013

Immunization prevents some dangerous diseases for children. Completeness of basic immunization is influenced by several factors. This study aims to determine the relationship between education, occupation, and maternal age with the completeness of basic immunization. This type of research is descriptive quantitative analytic with cross sectional method. This research was conducted in July 2013 at the Kuok-Riau Public Health Center. The number of samples is 75 and selected by non-probability sampling. Immunization status at the age of 30, 67.3% completed basic immunization and 32.7% did not complete basic immunization. For mothers aged 30 years, 30.4% completed basic immunization and 69.68% did not complete basic immunization. For mothers with education &lt;9 years, 37.9% did not graduate and 62.1% graduated. For mothers with 12 years of education, 67.4% graduated and 32.6% did not graduate. For working mothers, 68.3% completed and 31.7% did not. Housewives, 41.2% completed and 58.8% did not. The results of correlation analysis with Chi-Square test obtained p-value 0.005 (p&lt;0.05), education with immunization, p-value 0.017 (p&lt;0.05), work status with immunization, p-value 0.022 (p&lt;0 ,05). There is a relationship between maternal educational status, maternal employment status, and maternal age with immunization status.

Penyuluhan Tentang Imunisasi Dasar Lengkap Di Puskesmas Kapasa Kota Makassar

Low complete basic immunization coverage is still a very difficult problem to deal with. Government programs in an effort to improve the degree of children's health that is before the child is one-year-old basic immunization should be given in full according to his age. In this condition, the immune system is expected to work optimally with the effect caused to a minimum. This devotion aims to increase public knowledge about complete basic immunization so that basic immunization coverage can increase. The methods used are lectures and discussions. The implementation in Kapasa Public Health Center with the number of participants as many as 30 mothers. From the results of the extension, there is an increase in the knowledge and understanding of mothers so that it is expected that this training activity can be carried out in all the work areas of Public Health Center with government support.

Faktor-Faktor yang Berhubungan dengan Pemberian Imuisasi Dasar Balita Usia 0-12 Bulan di Wilayah Kerja Puskesmas Bayung Lincir Tahun 2021

Immunization is a way to increase a person's immunity to a disease, so that when he is later exposed to the disease he does not become sick. According to the World Health Organization (WHO) in 2014 as many as 22.6 million children worldwide were not covered by routine immunization. In 2015 an estimated 19.9 million babies worldwide were not achieved with routine immunization services such as 3 doses of DTP vaccine. This type of research uses an analytical survey method using a cross sectional approach. This research was conducted in the working area of the Bayung Lincir Health Center. The population in this study were all mothers who had children aged over 1 year totaling 1385 people. The number of samples used in this study amounted to 92 respondents. Based on the results of univariate analysis, the results obtained from 92 respondents, mostly complete basic immunization, which totaled 56 respondents (60.9%) and 36 respondents (36 respondents (39.1%). obtained value = 0.029, attitude variable value = 0.034 and family support variable value = 0.014 smaller than = 0.05 indicates there is a significant relationship between knowledge, attitude and family support with basic immunization in the work area of the Bayung Lincir Health Center 2021. There are suggestions for health workers/Puskesmas to further improve immunization services and public education/health counseling about complete basic immunization.

Optimization of "#infovaksin" covid-19 as an effort to increase coverage of basic immunization for toddlers during the pandemic

During the Covid-19 epidemic, delays/cessation of vaccination services resulted in a drop in basic immunization coverage for children in Sumampir Village owing to restrictions on direct contact and parental concerns. It is thought that education about the Covid-19 vaccination is crucial in order to avoid new concerns in children's health. This service intends to improve health cadre engagement in Sumampir Village in order to achieve a high level of health. The service technique includes giving vaccinations and Covid-19-related materials and training. This program was successful in strengthening the knowledge and abilities of health personnel in the area of child vaccination. In addition, partners may use their interpersonal communication skills to help the community learn about vaccination and Covid-19 vaccines.

Signs and symptoms of depression in children and adolescents with type 1 diabetes mellitus

Depression is a fundamental disorder characterized by changes in mood or affect toward depression with or without anxiety. Depression is a state of mental disorder characterized by three main symptoms and seven additional symptoms. Diabetes Mellitus Type-1 (T1DM) is a systemic disorder caused by impaired glucose metabolism, which is characterized by chronic hyperglycemia. Depression is common in patients with T1DM. In this case report, a 13-year-old girl was consulted because she looks sad. A feeling of sadness has been felt for 3 months and has been getting worse since a week ago, which was initially because of T1DM. Patients usually work at home and carry out daily activities as usual. Currently, the patient has no desire and gets tired easily, especially when doing usual activities, thinking the pain will get worse and thinking that she can't recover. Complaints are felt throughout the day and worsen at night, especially before bed or when alone. The patient feels that she is useless and his future is bleak. During pregnancy, the patient's mother routinely checks with the midwife and gets complete immunizations. The patient was born vaginally and cried spontaneously. The patient also received complete basic immunization.

Association between Maternal Health Care and Basic Immunization Completeness in Children Aged 12–23 Months: Analysis of 2017 Indonesian Demographic and Health Survey

BACKGROUND: The coverage of complete basic immunization in Indonesia is still lower than the target stated in the 2015-2019 Ministry of Health Strategic Plan. It may be caused by several factors, one of the essential factors is maternal health services. AIM: The study aims to assess the association between maternal health services and immunization completeness in Indonesian children aged 12–23 months. METHODS: A cross-sectional design was conducted using the 2017 Indonesian Demographic Health Survey. Two-stage stratified random sampling was used to obtain representative samples from all provinces in Indonesia. The subjects of this study were mothers who had children aged 12–23 months. A total of 3,398 samples were obtained after considering the inclusion and exclusion criteria. The data were analyzed using chi-square and logistic regression. RESULTS: The prevalence of complete immunization of Indonesian children aged 12–23 months was 61.4%. From multivariate analysis, we found that mothers who attend more than four antenatal care (ANC) (Adjusted odds ratio [AOR] 3.23 95% Confidence interval [CI] [2.31–4.52]), delivery by health-professionals (AOR 3.32 95%CI [2.26–4.88]), and attended postnatal care (PNC) (AOR 1.31 95% CI [1.07–1.59]) were predictors of complete child immunization. In addition, children whose mothers had a higher educational level and who live in Java-Bali were more likely to be completely vaccinated. CONCLUSION: Maternal health services, which consist of ANC services, delivery by health workers, and PNC services, were associated with the completeness of basic immunization in Indonesian children aged 12–23 months. Strategies to improve immunization coverage must be carried out by increasing the continuity of maternal health services since pregnancy, childbirth, and postpartum.

Determinants of immunization status of children under two years old in Sumatera, Indonesia: A multilevel analysis of the 2020 Indonesia National Socio-Economic Survey

BackgroundThe success of a basic immunization program among children has been known as the cheapest and most effective approach in improving child survival against preventable diseases. This study aims to examine the determinant factors at the individual and contextual level that affect the provision of complete basic immunization for children aged 12–23 months in Sumatra, Indonesia. MethodsUsing the 2020 Indonesia National Socio-Economic Survey (SUSENAS) data, a multilevel binary logistic regression model was developed at the individual level and the regency/municipality level as the first and second level of analysis respectively. ResultsThere are 30.8% of children aged 12–23 months who received complete basic immunization in Sumatra. Meanwhile, there are still 10.3% of children who did not receive basic immunization at all. The place of residence, mother's education, mother’s employment status, and place of delivery had a positive and significant effect on completeness of basic immunization for children, while the health facilities/100,000 population had a negative and significant effect on completeness of basic immunization for children which may correlate to the inequality of health facilities distribution in Sumatra. ConclusionThe difference in characteristics between regencies/municipalities in Sumatra, Indonesia can be explained by 18.90% of the variation in the coverage of basic immunization completeness for children aged 12–23 months in Sumatra. The Indonesian government and related institutions can further improve the distribution of health workers and adequate health facilities to cover remote areas.

The Effect of Maternal and Child Factors on Stunting in Children Under Five Years in Rural Indonesia

Indonesia has the fifth largest prevalence of stunting in the world. The results of the 2013 Basic Health Research showed that the prevalence of stunting in toddlers in Indonesia was 37.2%. In Cianjur District, the prevalence of stunting in 2017 reached 35.7%. The purpose of this study was to analyze the effect of maternal and child factors on stunting in children under five years in Cikancana, Cianjur District, in rural Indonesia. The study used an analytical design with a case-control approach. 42 mothers were included who had children under five years with stunting and 42 mothers who had healthy children. Data analysis was through the Chi-square test and multiple logistic regression. The results showed that, of the maternal factors, gestational weight gain and anemia during pregnancy were significantly related to stunting (both p &lt; 0.001), while maternal height (p = 0.068) and maternal nutritional status during pregnancy (p = 0.801) were not significantly related to stunting. None of the child factors were significantly related to stunting, namely birth weight (p = 1.000), birth length (p = 0.156), early breastfeeding initiation (p = 1.000), exclusive breastfeeding (p = 0.175), complete basic immunization (p = 0.713), or history of infectious diseases (p = 1.000). Multiple logistic regression showed that anemia during pregnancy was the most influential factor for stunting in children under five years (OR 18.41; 95% CI 3.43-98.75; p &lt; 0.001). Pregnant women need to be prepared by taking iron supplementation tablets during pregnancy so that anemia can be prevented.&#x0D; Keywords: stunting, maternal factors, child factors

The Determinants of COVID-19 Vaccine Acceptance in Sumatra

In light of the current vaccination programs being implemented worldwide, this study aimed to evaluate the determinants of coronavirus disease 2019 (COVID-19) vaccine acceptance in Sumatra, Indonesia. According to a COVID-19 vaccine acceptance survey conducted in Indonesia by the World Health Organization (WHO), the Ministry of Health of the Republic of Indonesia, the National Immunization Technical Advisory Group (NITAG), and the United Nations Children’s Fund (UNICEF), published in November 2020, Sumatra is among the places having lower COVID-19 vaccine acceptance rates, with Aceh Province displaying the lowest level of vaccine acceptance. Thus, a cross-sectional study was conducted, and a logistic regression analysis was used to identify the factors affecting COVID-19 vaccine acceptance. Out of 368 respondents who participated in the survey, 143 (38.9%) accepted the vaccine, and 225 (61.1%) refused it. Vaccine safety concerns constituted the most reported reason for refusal (43.6%). This study also found that province of residence and basic immunization status were determinants of COVID-19 vaccine acceptance in Sumatra. Concerns regarding vaccine safety might be the reason for the low level of vaccination in Sumatra. Increased education and encouragement from healthcare professionals and regional authority figures can alleviate public concerns and improve vaccine acceptance.

Pendidikan Kesehatan Media Booklet Mengurangi Kecemasan Ibu pada Imunisasi Dasar di Era Pandemi Covid-19

The Covid-19 pandemic has changed customary procedures, including causing disruptions in routine immunization programs. At the beginning of the Covid-19 pandemic in Indonesia, posyandu services had stopped and finally, during the implementation of immunization service activities, there was a decline. Data from observers of child immunization found that 83.9% of immunization services were disrupted due to the Covid-19 pandemic, the results in April 2020. One of factors was the feeling of worry and fear of mothers being infected with Covid-19 in health facilities including posyandu. Education is needed to change behavior of individuals for the better on this matter. This study aims to analyze health education with booklets on maternal anxiety in providing basic immunization in the era of the Covid-19 pandemic. The design of this study used quasi-experimental, data analysis using the Mc. Nemar. The results, there was an effect of providing health education with booklet media on the anxiety of mothers of babies 0-12 months in giving immunizations in the era of the covid-19 pandemic in the Desa Pekan Tanjung Morawa in 2021 with a p-value 0.015. There was a decrease in the number of respondents with mild anxiety from 65% to 33%, and no more respondents with moderate anxiety levels were found. The number of respondents who were not anxious increased by 39 people. The results of this study need to be carried out holistically related to immunization during the pandemic and others using booklets. &#x0D; Keywords: Health Education, Immunization, Maternal Anxiety, Media Booklets , The Covid-19 Pandemic