Basic Centers Research Articles

Linear amine‐functionalized frameworks designed as superior bifunctional catalysts for carbon dioxide cycloaddition under co‐catalyst and solvent‐free conditions

In this work, three bifunctional metal‐organic frameworks (MOFs) were constructed through the introduction of various linear amine functional groups within MIL‐101(Cr). The unsaturated chromium metal center was incorporated with three various ligands including ethylene diamine, diethylene triamine, and diamino butane. The resultant prepared MOFs contain unsaturated chromium centers as Lewis acidic centers and amine groups as basic sites. The contemporary existence of basic and acidic centers allowed prepared bifunctional compounds to be highly effectual heterogeneous catalysts for chemical fixation of CO2 with epoxides, affording cyclic carbonates, under relatively mild conditions and in the absence of either solvent or cocatalyst. High tendency of prepared structures toward CO2 adsorption followed by speeding up the nucleophilic attack resulted in gaining excellent conversion, selectivity, and activity for large epoxide as well as bulky ones. The synthesized catalyst outperforms other reported heterogeneous catalysts. High conversion, TON, recyclability, and mild reaction conditions are some distinctive characteristics of the bifunctional synergetic catalysts.

Modeling Accessibility to Emergency Obstetric Care in Mountain Region on Adonara Island, Eastern Indonesia

The geographical conditions of an area influence accessibility problems. The difficult geographical conditions caused travel time to the location of the obstetric emergency center to be very long. One of the causes of the high maternal mortality rate in Eastern Indonesia is the long time to travel to Basic Emergency Obstetrics Cares. This study aims to model the travel time to the PONED-Pelayanan Obstetri Neonatal Emergensi Dasar (Basic Emergency Obstetric and Neonatal Care-BEmONC) in a mountain region. The difficulties in access to obstetric care could cause maternal mortality in mountain regions. This study was done on the island of Adonara in the Flores Timur district. Adonara Island has a high maternal mortality rate. Modeling accessibility used a raster-based model to model travel time. The data used Landsat 8 imagery, Digital Elevation Model (DEM), and road network data to obtain a land cover layer. The Saga GIS travel time calculation tool is used to calculate the accumulated cost of travel time. The cost is based on the speed of travel through each land cover pixel to the location of the Puskesmas Waiwerang (PONED 1) and Puskesmas Waiwadan (PONED 2). The results of the travel time modeling show that people living in five sub-districts reach the two PONED locations in ≥ 1 hour. The longest time for people to travel to PONED is ≥ 6 hours from Ile Boleng sub-district because there is a mountain in the Ile Boleng sub-district. The scenario of adding one PONED shows that only people living in two sub-districts reach the PONED ≥ 1 hour. This spatial modeling of travel time to the location of the PONED (emergency obstetric care) can be used by local governments in eastern Indonesia to improve access to the location of basic obstetric emergency health centers in mountain areas.

Unraveling Molecular Assembly and Tracking Lipid Droplet Dynamics Using Fluorescent Phenanthroimidazole Derivatives

Small strategic perturbations of the molecular structures impart significant variation in the evolution dynamics and properties of supramolecular self-assembled architectures. However, probing the in situ evolution dynamics of molecular assembly remains a challenge. Herein, we unraveled the real-time, early stage environment-sensitive dynamic molecular self-assembly processes and stimuli-induced reversible morphological transformation between supramolecular fibers and spherical nanoaggregates of alkyl chain-substituted phenanthroimidazole-based luminogen (BPIB1) through fluorescence lifetime imaging microscopy (FLIM). The presence of an octyl chain and basic nitrogen centers in BPIB1 led to a distinct self-assembly pattern. The gradual progression in the fluorescence lifetime provides a unique strategy for elucidating the dynamics of the self-assembly process leading to distinct nano/microarchitectures. Among the varied self-assembled structures, the smaller-sized (diameter ∼ 20–30 nm), highly photostable, water-dispersible, and biocompatible fluorescent nanoaggregates of BPIB1 were employed for tracking the dynamics of lipid droplets in live cells and a model organism, C. elegans, using fluorescence correlation spectroscopy and FLIM. Thus, a combined microscopic and spectroscopic approach demonstrated in the present study opens up new avenues to explore the formation pathways of diverse molecular aggregates and their use to decipher complex organelle dynamics.

The Consequences of Water Interactions with Nitrogen-Containing Carbonaceous Quantum Dots-The Mechanistic Studies.

Despite the importance of quantum dots in a wide range of biological, chemical, and physical processes, the structure of the molecular layers surrounding their surface in solution remains unknown. Thus, knowledge about the interaction mechanism of Nitrogen enriched Carbonaceous Quantum Dots' (N-CQDs) surface with water-their natural environment-is highly desirable. A diffusive and Stern layer over the N-CQDs, characterized in situ, reveals the presence of anionic water clusters [OH(H2O)n]-. Their existence explains new observations: (i) the unexpectedly low adsorption enthalpy (ΔHads) in a pressure range below 0.1 p/ps, and ΔHads being as high as 190 kJ/mol at 0.11 p/ps; (ii) the presence of a "conductive window" isolating nature-at p/ps below 0.45-connected to the formation of smaller clusters and increasing conductivity above 0.45 p/ps, (iii) Stern layer stability; and (iv) superhydrophilic properties of the tested material. These observables are the consequences of H2O dissociative adsorption on N-containing basic centers. The additional direct application of surfaces formed by N-CQDs spraying is the possibility of creating antistatic, antifogging, bio-friendly coatings.

Ambiphilic Behavior of Ge(II)-Pseudohalides in Inter- and Intramolecular Frustrated Lewis Pair Alkyne Addition Reactions.

The reaction of the germylene chloride (NacNac)GeCl (1, NacNac = CH{(CMe)(2,6-iPr2C6H3N)}2), phenylacetylene, and B(C6F5)3 gives the intermolecular frustrated Lewis pair (FLP) addition product 2. In this case, the Ge(II) center acts as a base. In contrast, the analogous reaction of germylene thiocyanate 3 reacts independently with B(C6F5)3 to give the germylene cation salt [(NacNac)Ge][SCNB(C6F5)3] 4. Subsequent in the presence of alkynes, the Ge(II) cation and γ-C of 4 act as a Lewis acidic and basic center, respectively, to affect the addition of alkynes, affording products [(NacNac)Ge(RCCR')][SCNB(C6F5)3] 5 and 6. Compound 4 also reacts with Me3SiCN to give the cyanide-bridged Ge/B species 7, which also reacts with phenylacetylene to give CN abstraction and intramolecular addition yielding the salt [(NacNac)Ge(PhCCH)][NCB(C6F5)3] 8. Despite the similarity of 1 and 3, DFT calculations show that the highest occupied molecular orbital (HOMO) of 1 is mainly located at the more sterically hindered germylene center, while the HOMO of 3 is located on the less sterically hindered NCS group, prompting markedly different FLP addition products.

Effect of pH on the Redox and Sorption Properties of Native and Phosphorylated Starches.

Starch is a common biopolymer that can be used for removing heavy metal ions from aqueous solutions. A valuable property of starch is its functional diversity, which can be enhanced by chemical modification. Hydroxyl groups enclosed in the starch and formed during hydrolysis act as reducing agents of Cr(VI). The sorption properties of native starch depend mainly on the presence of carboxyl groups formed during redox processes and basic centers created during acid hydrolysis, while the superiority of phosphorylated starch is related to the presence of phosphate groups binding Cr(III) ions. The effectiveness of starch depends on a series of equilibria established in its aqueous suspension and chromate ions solution, where the pH is the driving force for these processes. In this article, a systematic discussion of pH changes being the consequence of chemical reactions unraveling the extraordinary functionalities of starch was given. It also explained the influence of establishing equilibria and chemical modifications of starch on the efficiency of chromium ion removal. This allowed for the development of a comprehensive mechanism for the interaction of Cr(VI) and Cr(III) ions with native and phosphorylated starch.

Research on the Construction of Urban Leisure Physical Culture Healthy Big Data Service Platform Based on In-Depth Learning

The national fitness service system must focus on meeting the sports needs of residents, innovate the construction mode of urban leisure sports big data service platform, and promote the construction of urban leisure sports health big data service platform. The healthy development of urban leisure sports should also adhere to the principles of demand orientation and problem awareness. Big data is an industry with urban leisure and sports health as its core data. It is a production process that continues to cycle in the life cycle of big data. Therefore, this paper uses in-depth learning to study the construction of big data service platform for urban leisure sports health. The in-depth learning improvement project is an expert team organized by the urban leisure sports health basic textbook development center of the Ministry of education. The data revolution driven by deep learning examined the value of data, conquered the data ocean, and created a new era of personalized medicine in the fields of urban leisure, sports, and health. On the basis of in-depth learning, this paper constructs a big data service platform for urban leisure sports health. On the one hand, the establishment of this platform will help to speed up the construction process of sports service informatization and the reform of various fields of sports, on the other hand, it will help to promote the improvement of the physical quality of the whole people.

Base modified organic mesoporous silicas, their characterization and application in the aldol reaction of n-butanal

Representative ordered mesoporous silica materials MCM-41 and SBA-15 were synthesized and modified with nitrogen-containing groups by grafting and co-condensation. The created catalytic centers strongly differ in basicity depending on the degree of substitution of the nitrogen atom. Furthermore, the introduced amount also depends on the structure of the modifier as shown by quantitative liquid phase 1H NMR. This allowed to calculate the turnover number in the aldol condensation of n-butanal which changed in the sequence: secondary > primary >> tertiary >> pyridinic basic centers. Corresponding reaction mechanisms considering the special structural features of the modifier are proposed.

PROJECTION OF THE DEVELOPMENT TRENDS OF THE KHARKIV REGIONAL POPULATION SETTLEMENT SYSTEM IN THE CONDITIONS OF POST-WAR RECONSTRUCTION

Geopolitical and socio-economic trends, the development and implementation of new technologies, the increase in consumption volumes in the conditions of the growth of the population of the planet in a geometric progression form new challenges and requirements for the creation of modern settlement systems of a new formation: a digital, human-centric and balanced functional-spatial model of territorial development, which would combine the provision of the growing human needs and its harmonious coexistence with the surrounding environment. In the conditions of the beginning of the full-scale military aggression of the Russian Federation against Ukraine, the population displacement processes have changed radically. The main indicator for the move was safety. Processes of population movement from the territories of large cities to rural areas away from the areas of active hostilities, shelling and missile strikes are being observed. The migration crisis significantly affects the socio-economic processes in the country. The main condition of post-war reconstruction is the return of the able-bodied population, which will ensure the restoration of pre-war GDP indicators. Therefore, it is expedient to model the results of the post-war resettlement system. For example, the Kharkiv regional resettlement system was chosen as the research object. The pre-war trends in the development of settlement systems were analyzed. In particular, the hypothesis of the interdependence of population density indicators with the indicator of distance from the basic center of gravity is put forward. It is statistically proven that population decline is more intense in rural areas. The results of a sociological survey of forcibly displaced persons and the forecasting of their displacement in the conditions of post-war reconstruction are given. A projection of optimistic, realistic, and pessimistic scenarios has been developed.

THE IMPACT OF DELIVERY COMPLICATIONS ON PUBLIC TIME AT BASIC EMERGENCY NEONATAL OBSTETRIC SERVICES KLATEN DISTRICT IN 2019


 
 
 
 Abstract (10 PT).
 Labor and postpartum complications often occur during and after delivery. Generally, severe complications will cause maternal death, but moderate or mild complications can cause maternal and postpartum morbidity. However, little research is available on the impact of postpartum and postpartum complications on women's lives. The method used in this study is a quantitative method with an analytic observational type of research with a prospective cohort approach. The sample in this study were mothers who gave birth vaginally at the Basic Emergency Neonatal Obstetric Services Public Health Center, Klaten Regency, both normal and complicated childbirth who had met the inclusion and exclusion criteria with a total of 57 respondents. .Data analysis used univariate and bivariate analysis with chi square test. The results of this study are that there is an impact of labor complications during the puerperium which is described as: there is a relationship between childbirth complications and prelactal feeding p value = 0.006, there is a relationship between labor complications and postpartum blues, p value = 0.01, and there is a relationship between labor complications and postpartum depression. partum, p value = 0.001. It is recommended for midwives to pay more attention to the postpartum period for mothers who experience childbirth complications
 
 
 
 

Nickel–magnesium-modified cenospheres for CO2 methanation

Coal combustion for power generation is a source of CO2 emission into the atmosphere. During that process, waste materials are formed such as cenospheres, which are a fraction of fly ashes. These cenospheres were applied as a catalyst support for the CO2 methanation reaction, which is a promising process for carbon dioxide utilization. Two series of catalysts were compared, a reference one based on the unmodified cenospheres, and a second based on the cenospheres modified by perforation. Nickel supported on Cenospheres nickel, or else nickel with Mg–Al mixed oxides, were prepared by solution combustion synthesis. Perforated cenospheres supporting Mg–Al mixed oxides led to a catalyst with significantly improved catalytic performance (88% at 300 °C) and selectivity to methane (>99% at 300 °C). In this work we evidence better development of the specific surface area, increased surface basicity, improved dispersion of nickel crystallites thanks to the presence of Mg–Al and enlarged number of basic centers at the surface.

Efficiency analysis of primary healthcare facilities in Afghanistan

BackgroundAfghanistan’s health system is unique in that primary healthcare is delivered by non-governmental organizations funded by multilateral or bilateral donors, not the government. Given the wide range of implementers providing the basic package of health services, there may be performance differences in service delivery. This study assessed the relative technical efficiency of different levels of primary healthcare services and explored its determinants.MethodData envelopment analysis was used to assess the relative technical efficiency of three levels of primary healthcare facilities (comprehensive, basic, and sub-health centers). The inputs included personnel and capital expenditure, while the outputs were measured by the number of facility visits. Data on inputs and outputs were obtained from national health information databases for 1263 healthcare facilities in 31 provinces. Bivariate analysis was conducted to assess the correlation of various elements with efficiency scores. Regression models were used to identify potential factors associated with efficiency scores at the health facility level.ResultsThe average efficiency score of health facilities was 0.74 when pooling all 1,263 health facilities, with 102 health facilities (8.1%) having efficiency scores of 1 (100% efficient). The lowest quintile of health facilities had an average efficiency score of 0.36, while the highest quintile had a score of 0.96. On average, efficiency scores of comprehensive health centers were higher than basic and sub-health centers by 0.11 and .07, respectively. In addition, the difference between efficiency scores of facilities in the highest and lowest quintiles was highest in facilities that offer fewer services. Thus, they have the largest room for improvement.ConclusionsOur findings show that public health facilities in Afghanistan that provide more comprehensive primary health services use their resources more efficiently and that smaller facilities have more room for improvement. A more integrated delivery model would help improve the efficiency of providing primary healthcare in Afghanistan.

Role of Zirconia in Oxide-Zeolite Composite for Thiolation of Methanol with Hydrogen Sulfide to Methanethiol.

In this paper, the molecular sieve NaZSM-5 was modified with zirconium dioxide (ZrO2) by a hydrothermal coating process and other methods. By comparing the effects of the crystal phase structure of ZrO2 and the compositing method on the physicochemical properties and catalytic performance of the obtained composites, the structure–performance relationship of these composite catalysts was revealed. The results indicate that in the hydrothermal system used for the preparation of NaZSM-5, Zr4+ is more likely to dissolve from m-ZrO2 than from t-ZrO2, which can subsequently enter the molecular sieve, causing a greater degree of desiliconization of the framework. The larger specific surface area (360 m2/g) and pore volume (0.52 cm3/g) of the m-ZrO2/NaZSM-5 composite catalyst increase the exposure of its abundant acidic (0.078 mmol/g) and basic (0.081 mmol/g) active centers compared with other composites. Therefore, this catalyst exhibits a shorter induction period and better catalytic performance. Furthermore, compared with the impregnation method and mechanochemical method, the hydrothermal coating method produces a greater variety of acid–base active centers in the composite catalyst due to the hydrothermal modifying effect.

Effectiveness of an instructional program on mothers knowledge toward child vaccines at primary health care centers in AlـNajaf City

Objective(s): The objective of this article is to identify the effectiveness of an instructional program toward mothers' knowledge of child vaccines as well as find the relationship between mothers' knowledge of child vaccines and their demographic data. Methodology: A quasi-experimental study is conducted for the period of October 4th, 2021 to April 19th, 2022. A nonprobability "purposive" sample of (60) mothers (30) for the control group and (30) for the study group was used in the study. Six basic health care centers in the Iraqi city of Al-Najaf were chosen for the sampling. The data is collected using a self-report questionnaire with two parts: the first part deals with the mothers' demographic information and previous history, and the second portion deals with the mothers' knowledge of child vaccines. Results: According to the findings, there is a significantly difference in mothers' knowledge about child immunizations between the study group's post-test knowledge score Except for the educational and occupational status, where there is a statistically significant association. In the control group, there is no significant relationship between mothers' knowledge and demographic characteristics such as age, education, or socio-economic status.

A comprehensive theoretical analysis on the intermolecular hydrogen bond interactions with the Lewis bases having multiple hydrogen bonding abilities

AbstractThis work comprehensively studies the intermolecular H … O and H … N hydrogen bonding (HB) interactions between 3H‐pyrrol‐3‐one as a computationally simple model Lewis base (LB) comprising two different basic centers (sp2 hybridized O and N atoms) and hydrogen halides (Hal‐H, Hal = F, Cl, Br, and I) as common Lewis acids (LAs). In an equimolar mixture of LB and any of LAs, the formation of H … O and H … N HBs can compete with each other over the course of binary (dimer) complexation processes. Computed values of counterpoise‐corrected interaction energies (CP‐IE) together with energy decomposition analysis (EDA) through symmetry‐adapted perturbation theory (SAPT) reveal that these HBs should be classified as “weak‐to‐medium” ones which are mainly dominated with electrostatic interactions. Among many explored correlation analyses, within the binary complexes formation, the values of CP‐IE are perfectly linearly correlated with those of electron density at the bond critical points of the mentioned HBs, , leading to two different regression equations as ‐ . These equations allow that an accurate prediction of the value of CP‐IE for H … O and H … N HBs is made feasible using the value of easily and rapidly computable without an explicit (direct) calculation of the so costly CP‐IE. Such equations, also, were used to accurately and individually predict CP‐IE values in ternary (trimer) complexes where both of approximately pairwise additive H … O and H … N HBs can be formed at once. Moreover, in terms of the calculated values of cooperativity energies, these two HBs make each other weaken portraying an anticooperativity in the ternary complexes studied.

Adsorption of doxorubicin on the surface of magnetically sensitive nanocomposite Fe3O4/Al2O3/С

Fe3O4/Al2O3/С nanocomposite was synthesized and characterized by a complex of physicochemical methods. The completeness of carbonization was confirmed by the method of TPD MS, and the results of TEM, EDX and changes in the values of the specific saturation magnetization proved the formation of the structure of Fe3O4/Al2O3/С by the type of core-shell. According to the results of potentiometric studies, the characteristics of acid -basic centers were quantitatively and qualitatively assessed. The adsorption of Doxorubicin (DOX) on the surface of Fe3O4/Al2O3/С was performed and the adsorption process depending on the contact time, pH of the solution and DOX concentration was studied. The experimental results of kinetic studies were analyzed for compliance with of Boyd, Morris-Weber and Elovich the theoretical models, models of pseudo-first and pseudo-second orders. Langmuir and Freundlich isotherm models were used to model adsorption processes. Under the conditions of the experiment (pH = 5) active basic centers (С = 8.46⋅10−5 mol⋅g −1, Кі = 1.296⋅10−5 (рК = 4.887)). Adsorption processes occur by a mixed diffusion mechanism, limiting processes are intraparticle diffusion and chemisorption processes of molecular and ionic forms of DOX. The highest correlation coefficient was r 2 = 0.971, the correlation of theoretical and practical values of the adsorption capacity (A mg g −1) indicates the possibility of using the Freundlich model to describe the adsorption of DOX on the surface of Fe3O4/Al2O3/C. Desorption processes practically do not occur at pH 7.4 (change of value A from 30.56 to 30.12 mg g −1, which is − 1.83%), at pH 5 percent of desorbed DOX is higher − 2.88% (change in value A from 30.21 to 29.51 mg g −1).

Integrated Quantum Mechanical and Machine Learning Methods Enable Scalable and General pKa Prediction for Pharmacokinetic Modeling

We present the development of the BIOiSIM™ pKa model for predicting aqueous molecular ionization. Assessment and optimization of drug pKa occurs early in drug discovery; thus, models for high‐throughput pKa prediction must balance computational cost, scalability, accuracy, and applicability to diverse chemical structures. Key to our pKa prediction model is a set of low computational cost, quantum mechanical charge descriptors that incorporate not only ionizable group charges, but the additional atoms and bonds likely to modulate pKa. The finalized machine learning models produced good accuracy on the test holdout set (R2 = 0.9, mean absolute error = 0.6−0.7, root mean square error = 1.0) and show good generalizability predicting the most acidic and basic ionization centers of the SAMPL6 external benchmark validation set (mean absolute error = 0.8, root mean square error = 1.0). Performance of the model is comparable to commercial pKa predictors but is trained on less data and exhibits higher scalability needed for pharmacokinetic modeling.

Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor.

The nonclassical extracellular signal-related kinase 5 (ERK5) mitogen-activated protein kinase pathway has been implicated in increased cellular proliferation, migration, survival, and angiogenesis; hence, ERK5 inhibition may be an attractive approach for cancer treatment. However, the development of selective ERK5 inhibitors has been challenging. Previously, we described the development of a pyrrole carboxamide high-throughput screening hit into a selective, submicromolar inhibitor of ERK5 kinase activity. Improvement in the ERK5 potency was necessary for the identification of a tool ERK5 inhibitor for target validation studies. Herein, we describe the optimization of this series to identify nanomolar pyrrole carboxamide inhibitors of ERK5 incorporating a basic center, which suffered from poor oral bioavailability. Parallel optimization of potency and in vitro pharmacokinetic parameters led to the identification of a nonbasic pyrazole analogue with an optimal balance of ERK5 inhibition and oral exposure.

A Novel Energy-Aware Routing in Wireless Sensor Network Using Clustering Based on Combination of Multiobjective Genetic and Cuckoo Search Algorithm

The development of various applications of wireless sensor networks has aroused great interest in using these types of networks in various fields. These networks, without infrastructure and self-organization, are easily deployed in most environments and collect information about environmental phenomena for analysis and proper response to accidents and send them to the basic centers. They do. Wireless sensor networks are made up of some sensor nodes that both act as sensors and act as relay nodes concerning to each other. On the other hand, the lack of infrastructure in these networks has limited resources so that the nodes of the battery are fed with limited energy. Due to the location of networks in difficult and impassable areas, it is not possible to recharge or replace the node battery. Therefore, saving energy consumption in this type of network is one of the most important challenges. Since the rate of energy consumption when sensing information and receiving data packets from another node is a fixed value, so sensor nodes have the highest energy consumption when sending data. Therefore, routing methods try to reduce energy consumption based on systematic approaches. One of the most promising solutions to reduce energy consumption in wireless sensor networks is to cluster the nodes and select the threaded node based on the data transfer parameters so that the average energy consumption in the nodes is reduced and the network lifetime is increased. Therefore, in this research, a new optimization approach using multiobjective genetic algorithm and cuckoo algorithm for clustering wireless sensor networks is presented. In this study, in order to select clustered nodes from a multiobjective genetic algorithms based on reducing intracluster distances and reducing energy consumption in cluster member nodes and near-optimal routing based on cuckoo optimization algorithm to transfer information between nodes have been used in the direction of the cavity. The implementation results show that considering the evolutionary capabilities of the multiobjective genetic algorithm and the cuckoo optimization algorithm, the proposed method in terms of energy consumption, efficiency, delivery rate, and packet transmission latency, compared to previous methods, has improved.

Building Indian Biomedical Leadership to Bridge the Gap Between Science, Primary Health Care and Public Health.

The Indian biomedical landscape has been characterized by the existence of somewhat polarized institutional structures and professional growth. While some scientific and public health challenges have been met with existing structures, there is still a large unmet scientific and public health need. Broadly, the physical separation of science, engineering, medical campuses and industry has led to silos of excellence and accomplishment with huge gaps in innovation and implementation. The lack of inter-disciplinary educational options has further reinforced the cultural underpinning of “guilds” that have found it difficult to collaborate. Strikingly, with almost a comparable number of institutions that train doctors in the allopathic or traditional disciplines such as Ayurveda, Unani etc., an “integrative medicine” framework has not emerged, apart from an over reliance on specialization at the expense of primary care. This paper is written by two physician-scientists, the first is located in a basic life science research center. The second, a practicing family physician, from the institutional anchor of a life sciences research institution. In this, we trace our experiences, primarily from a principal investigator’s perspective, describing the scientific projects and try to explore the lessons learnt along the way. We will first describe the research in the lab’s core area of human cervical cancer progression and our more recent effort with Dengue genomics and vaccine design. We then describe the lab's engagement with medical campuses and other agencies as well as review our various meetings and interactions so far with our colleagues from Africa to grasp what might be the “generalizable lessons” for the future. The Indian council of medical research initiated a program with Africa in health sciences. Building upon those interactions, we have taken some incremental steps in that direction and described our efforts.