Background: Prehypertension is undetected and considered a precursor of hypertension and cardiovascular diseases. Prehypertension can be attributed not only to diet patterns and lifestyle but also to the basic cause such as sociodemographic factors. Understanding the sociodemographic factor and its relationship with prehypertension can adjust the best prevention action to control the rise of prehypertension. We aim to investigate the association between sociodemographic factors with prehypertension among healthy adults. Method: Cross-sectional study was conducted from 2016 to 2018 and involved 653 healthy adults 19 to 64 years of age in urban and rural areas in a province in Indonesia. The urban represented the most populated urban area and the rural represented lowland, mountainous, and coastal areas. The pregnant or breastfed woman was excluded. Data collection included sociodemographic, namely gender, age, educational degree, occupation, family history of diseases, smoking history, and dwelling area. A blood pressure of 120 to 139 mmHg (systolic) or 80 to 89 mmHg (diastolic) was classified as prehypertension. Logistic regression was run to determine the factors that influenced prehypertension. Result: Subjects were dominated by females (62.2%) and the prevalence of prehypertension was 66.5%. Gender, age, occupation, smoking history, and dwelling area were associated with prehypertension. Being female increased the risk 3.1 times higher of prehypertension than male (p < 0.001, 95% CI 2.1–4.5). The middle adult had a 2.9 times higher risk of prehypertension than early adults (p < 0.001, 95% CI 1.8–4.7), while no significant risk for the elderly compared to early adults. Civil servants or private officers had a 1.9 times higher risk of prehypertension than unemployed/housewives/students (p < 0.001, 95% CI 1.3–2.7). Smokers increased a 1.6 times higher risk of prehypertension than non-smokers (p = 0.018, 95% CI 1.1–2.3). Adults who were living in urban had a 1.5 times higher risk of prehypertension than adults in rural (p = 0.026, 95% CI 1.1–2.0). Conclusion: Being female, middle adult, working as civil servants or private officers, being active smokers, and living in urban were significant risk factors for prehypertension. The importance of designing different interventions which were suitable for the different sociodemographic backgrounds is important to control blood pressure. Keywords: sociodemographic, prehypertension, adults, urban, rural