Objective—Temporary biventricular pacing to treat low output states after cardiac surgery is an active area of investigation. Reoperative cases are not studied due to adhesions, which preclude left ventricular mobilization to place epicardial pacing wires. In such patients, inserting a temporary left ventricular lead via the coronary sinus cardioplegia cannula may allow for biventricular pacing. We developed a novel technique for intraoperative left ventricular lead placement. Methods—Eight domestic pigs underwent median sternotomy and pericardiotomy. Temporary pacing wires were sewn to the right atrium and right ventricle. Complete heart block was induced by ethanol ablation of the atrioventricular node. A 13 French retrograde cardioplegia catheter was introduced via the right atrial free wall into the coronary sinus. A 6 French left ventricular pacing lead was inserted into the cardioplegia catheter and advanced into the coronary sinus, during biventricular pacing, until left ventricular capture was detected by electrocardiogram and arterial pressure monitoring. Left ventricular capture success rate and electrical performance were recorded during five placement attempts. Results—Left ventricular capture was achieved on 80% of insertion attempts. Left ventricular capture without diaphragmatic pacing was achieved in seven pigs. Lead tip locations were mostly in lateral and posterior basal coronary vein branches. There were no arrhythmias, bleeding, or perforation associated with lead insertion. Conclusions—Intraoperative biventricular pacing with a left ventricular pacing lead inserted via the coronary sinus cardioplegia cannula is feasible, using standard instrumentation and without requiring cardiac manipulation. This approach merits further study in patients undergoing reoperative cardiac surgery. © 2010 The American Association For Thoracic Surgery. Published by Mosby, Inc. All rights reserved. Corresponding Author: Henry M. Spotnitz, M.D. Department of Surgery Columbia University Medical Center 622 West 168th Street Vanderbilt Clinic, 10th Floor, Room 1010 New York, NY, 10032 Telephone: 212-305-6191 Fax: 212-305-9724 hms2@columbia.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Disclosures: Dr. Spotnitz is the Principal Investigator on the National Institutes of Health RO1 Grant HL080152, “Biventricular Pacing After Cardiopulmonary Bypass.” He is also a member of the Scientific Advisory Board of Biophan Technologies, Inc. NIH Public Access Author Manuscript J Thorac Cardiovasc Surg. Author manuscript; available in PMC 2012 September 02. Published in final edited form as: J Thorac Cardiovasc Surg. 2011 July ; 142(1): 73–76. doi:10.1016/j.jtcvs.2010.08.028. N IH PA Athor M anscript N IH PA Athor M anscript N IH PA Athor M anscript