Abstract
Thematic Review Series: Sphingolipids. Ganglioside GM3 suppresses the proangiogenic effects of vascular endothelial growth factor and ganglioside GD1a
Highlights
Gangliosides are sialic acid-containing glycosphingolipids that have long been associated with tumor malignancy and metastasis
To examine the influence of GM3 on angiogenesis, we studied the proliferation of human umbilical vein endothelial cell (HUVEC) in culture
We evaluated the influence of GM3 on HUVEC proliferation either alone or in combination with GD1a in the presence of vascular endothelial growth factor (VEGF) stimulation (Fig. 1)
Summary
Gangliosides are sialic acid-containing glycosphingolipids that have long been associated with tumor malignancy and metastasis. Supplementary key words glycosphingolipid & human umbilical endothelial cell migration & matrigel plug assay & growth factor receptor & phosphorylated Akt of plasma membranes and have long been associated with tumor malignancy and metastasis [1,2,3]. These molecules contain an oligosaccharide head group that is attached to a lipophilic ceramide, consisting of a sphingosine base and a long-chain fatty acid. This article is available online at http://www.jlr.org
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