The banking sector is dependent on the economy and environment in which it operates for survival and stability. Lack of effective and efficient institutions and bad monetary policies may spell doom for a country’s banking system. In Nigeria, over the years, many banks did not become distressed, they have folded up as a result of problems relating to institutional quality and unfriendly monetary policies. This study, therefore, examined the effect of both institutional quality indicators and monetary policies on the fragility of the Nigerian banking system from 2000 to 2022. We used a dataset comprising six institutional quality and three monetary policy variables as well as the banking system fragility indices for the period 2000 – 2022. Having examined the statistical properties and conducted some pre-estimation tests, we employed the autoregressive distributed lag (ARDL) technique to determine the short and long run effects of the institutional quality and monetary policy variables on the banking system fragility index for the period. We found that, in the short run, in terms of institutional quality, only voice and accountability index had a declining effect on banks’ stability (worsening fragility) while with respect to monetary policy, loan-deposit ratio had a positive effect on the fragility index (reducing fragility). In the long run, neither the institutional quality nor the monetary policy variables have significant effect on the fragility index of the Nigerian banking system during the period. We conclude that institutional quality and monetary policy affect the Nigerian banking system fragility significantly in the short run and that the former have no significant effect on the latter on the long run. We recommend a focused approach on institutional reforms and periodic assessments and adjustments of the reforms, capacity building, improvement of institutional coordination, and ensuring that policies are not only well-designed but also effectively implemented and a continuous fine-tuning of monetary policies to adapt to changing economic conditions.