The study “examines Economic Recession and Survival of Selected Deposit Money Banks before and during the Covid-19 Era in Nigeria". It uses secondary data. The secondary data used is annual reports of selected deposit money banks from the year 2015 to 2020. The population size used for this study was the entire 14 Deposit Money Banks listed on the floor of Nigeria Stock Exchange, whose shares were traded by the Security and Exchange Commission in Nigeria during the period under review, while only 5 banks were adopted as sample size because they were identified by Moody’s Investors Service as the most affected banks in Nigeria during the last recession. Purposive sampling technique was adopted for the study, while regression and correlation analyses using E-views 9.0 statistical software packages were used to analyze the data and tested the formulated hypotheses at 5% level of significance. The study revealed that there is a significant effect between interest rate and banks' liquidity of Nigeria's deposit money banks, thus concluded that economic recession has a serious negative effect on the interest rate and inflation rate, which affects banks' survival variables like liquidity and share capital in the Covid-19 Era. It was recommended that the Central Bank of Nigeria in collaboration with Deposit Money Banks should coax interest rate on banks' liquidity downward in the areas of loans to stimulate the economy in case of another Covid-19 pandemic.