In this paper a comprehensive comparative study of three distinct microstrip patch antenna (MPA) designs, each optimized for the sub-6 GHz applications, is presented. The initial design phase utilized a Rogers RT 5880 substrate with a permittivity (εr1) of 2.2 and a thickness(H1) of 1.42 mm. The proposed model achieved a resonance band ranging from 4.8 to 7 GHz, with a bandwidth of 2.2 GHz and a return loss (S11) of -20 dB. Subsequent enhancements involved integrating a Barium Strontium Titanate (BST) thin film (εr2 = 250, thickness(H2) = 0.005 mm), effectively shifting the operational band to 3.5-5.3 GHz. The final design iteration, which incorporated both BST and a Defective Ground Structure (DGS), represented a substantial advancement, achieving wideband operation from 1.8 to 6 GHz, expanding the bandwidth to 4.2 GHz, and improving the S11 to -25 dB. This integration also resulted in a compact antenna size of 30 x 26.5 x 1.42 mm³. These findings underscore the synergistic impact of BST and DGS in enhancing MPA design, marking a significant progression in antenna technology, vital for a range of wireless communication.