Bandage Materials Research Articles

Wound Dressing Scaffold with High Anti-biofilm Performance Based on Ciprofloxacin-Loaded Chitosan-Hydrolyzed Starch Nanocomposite: In Vitro and In Vivo Study.

Today, the search for solutions to reduce wound infection and restore wound receptivity also reduces its side effects which are a difficult problem in medical science research. The greatest options for this purpose are hydrogel dressings since they are compatible with tissue and have an antibacterial effect on wound healing. Chronic wounds represent a significant burden on people and healthcare systems worldwide. Bacteria often enter such skin wounds, causing irritation and complicating the healing process. In addition, bacteria cause infection, which inhibits rejuvenation and the production of collagen. This study is aimed at developing novel chitosan (CS)-hydrolyzed starch nanocomposite (HS/Ch-NC) loaded with ciprofloxacin to enhance its skin retention and wound healing efficacy and anti-biofilm efficacy. Drug-loading on the (HS/Ch-NC) and encapsulation efficiency was 55.2% and 97.2%, respectively. The activity of HS-NC loaded with ciprofloxacin as anti-biofilm activity by 72% and 63% against Enterobacter aerogenes and Pseudomonas aeruginosa, respectively. The obtained (HS/Ch-NC) loaded with ciprofloxacin is a promising candidate for the development of improved bandage materials, as cell viability and proliferation was assessed using an SRB assay with half-maximal inhibitory concentrations (IC50) at 119.1µg/ml. In vitro scratch wound healing assay revealed significant (p ≤ 0.05) acceleration in wound closure at 24h enhanced by 56.04% 24-h and 100% 72-h post-exposure to (HS/Ch-NC) loaded ciprofloxacin, compared to the negative control. In vivo skin retention study revealed that (HS/Ch-NC)-loaded ciprofloxacin showed 3.65-fold higher retention, respectively, than ciprofloxacin. Thus, our study assumes that ciprofloxacin-loaded HS-NC is a potential delivery system for enhancing ciprofloxacin skin retention and wound healing activity.

Fabrication of AgNPs mediated fibrous membrane from Rhizophora mucronata mangrove plant extract for biological properties

The exploration of sustainable materials for nanotechnology will provide biomimicking excellent properties and process combination, respectively. The application of marine plants (MP) for biological applications is receiving a great attention nowadays due to the availability of active compounds in MP. The synergistic effect of nanoparticles synthesis through MP mediation and their potential drug delivery (using fibers/scaffolds) studies are not explored much so far. In the present study, the preparation, characterization, and in-vitro biological evaluation of PCL nanofibers loaded with silver nanoparticles obtained from Rhizophora mucronata mangrove plant leaf extracts were studied. In vitro antibacterial testing against Proteus mirablis, Bacillus cereus, Enterococcus sp., MRSA, Pseudomonas aeruginosa and Staphylococcus aureus were carried out and kanamycin (50 μg/ml) was used as a positive control. Potential antioxidant properties were established using scavengers such as DPPH, nitrous oxide and hydrogen peroxide at 150 μg/ml concentrations. The cell viability and proliferation of the AgNPs and AgNPs loaded nanofibers were evaluated using an MTT assay against the A549 Human Lung cancer cells. The novel AgNPs loaded nanofibers provide relatively rapid and accelerating wound healing activities in in vitro condition. Further, this study shows that AgNPs loaded nanofibers can act as a promising sustainable material for the development of improved bandage materials with an accelerated wound healing property.

Hardening the rolling surface of the wheels bandage after mechanical treatment

Article describes calculated argumentation of the striker sealing surface, in the form of the two cylinders with parallel axes model of loading, having an effect on the rim surface of the wheel pairs of rolling-stock. There has been presented a calculation variant of the depth of hard running surfacing of the rolling-stock wheel pairs. Installation of deep hardening of rolling surfaces of wheel sets allows the special striker to create certain forces on the rolling surface of the wheel rim, to deform the surface layer to a certain depth, thereby increasing the hardness of the deformed surface. The article presents the technology for hardening the wheel running surface by loading the surface of the wheel set bandage, by means of the deep hardening installation with the creation of strain stress in the surface layers for several combinations of tensile strength σB and velocity σT of various bandage materials.

Electrospun Poly Vinyl Alcohol Fiber Containing Lawsonia inermis L.: A Promising Effect on Burn Wound

Henna plant (Lawsonia inermis L.) has unique properties and has long been used as an herbal remedy. In this study, polyvinyl alcohol (PVA) nanofibers containing henna extract in two different concentrations were studied to prepare a wound dressing using electrospinning. PVA polymer nanofibers using henna extract with two different concentrations of 3% and 6% were prepared by the electrospinning method. Human fibroblasts were cultured on these fibers and the mechanical and survival properties of the cells, as well as the antibacterial properties of henna were compared and evaluated. The results showed that by using of henna extract in PVA nanofibers, cell viability was significantly reduced (P≤0.05). However, the ability of nanofibers to water uptake and mechanical properties of fibers significantly increased with increasing concentrations of henna extract (P≤0.05). Nanofiber wound dressing with antibacterial properties of henna extract provides relatively fast and rapid wound healing ability. The resulting fibers are encouraging candidates for the development of improved bandaging materials.

Antibacterial Polyacrylamide and Dextran-Graft-Polyacrylamide Hydrogels for the Treatment of Open Wounds

Background. Open wound treatment requires a use of bandage material to prevent the development of pathogenic microflora and to provide the necessary conditions for tissue regeneration.
 The aim of the study was to compare the effectiveness of polyacrylamide (PAA) and dextran-graft-polyacrylamide (D-PAA) hydrogels loaded with silver nanoparticles (AgNPs), antibiotics, and photosensitizers for the treatment of bacterial infection of open wounds.
 Materials and Methods. PAA and D-PAA hydrogels with AgNPs, methylene blue (0.001%) without (MB) and with red light irradiation (660 nm) (MB+L), chlorhexidine (0.05%) and cefuroxime (0.1%) were used. There were tested in vitro and in vivo (a rat model) antibacterial activities against wild-type Staphylococcus aureus, Escherichia coli, antibiotic-resistant Escherichia coli and Klebsiella pneumoniae strains obtained from the wound. Clinical investigations were performed in patients with chronic venous ulcers of the lower extremities with no response to traditional treatments.
 Results. S. aureus, E. coli, and K. pneumoniae strains were sensitive to PAA and D-PAA hydrogels with AgNPs, chlorhexidine, and cefuroxime. Antibiotic-resistant E. coli was not inhibited by the hydrogels with cefuroxime. This strain was less sensitive to chlorhexidine and MB+L. There were no differences between unloaded PAA and D-PAA hydrogels; the antibacterial properties of the dressing were determined by an antibacterial component loaded into the hydrogel. The use of unloaded D-PAA hydrogels in vivo helped reduce the size of the wound by 28.6% and 42.8% three and five days after wound modeling, respectively. Similar results were obtained for D-PAA hydrogels loaded with cefuroxime, chlorhexidine, and MB+L. D-PAA hydrogel with AgNPs reduced wound size by 50% and 62.5% three and five days after wound induction, respectively, demonstrated greater antibacterial activity and was selected for clinical investigations. In a patient, 14 days after bandage application, the fibrin membrane disappeared, the ulcers were covered with pink granulations, marginal epithelialization appeared.
 Conclusions. PAA and D-PAA hydrogels can be loaded with the antibacterial compounds of various types. The type of polymer does not affect the antibacterial properties of the final hydrogels. The hydrogels with chlorhexidine and MB+L can be potentially used to treat bacterial contamination of wounds and ulcers. Nevertheless, their disadvantage is the inability to absorb or precipitate tissue breakdown products that interfere with normal regeneration and inflammation. D-PAA/AgNPs are the best option for treating ulcers due to the ability to control the properties of the hydrogels and nanoparticles, as well as multiple mechanisms of antibacterial action.

Synthesis of Cu(II) coordination compounds with 2-amino-2-hydroxymethyl-1,3-propanediol, their modification and bactericidal action

The procedure for the synthesis of Cu(II) coordination compounds with 2-amino-2-hydroxymethyl-1,3-propanediol (TPIS, NH2C(CH2OH)3) of various types: protonated [Cu(TRIS)2]SO4, partially deprotonated [Cu(TRIS2–H)H2O]ClH2O and intracomplex [Cu(TRIS–Н)2]5Н2О has been developed. Elemental analysis of the compounds obtained was carried out and their solubility, pH and conductivity of their solutions were determined. The synthesized compounds were studied by means of electron and IR-spectroscopies, magnetic susceptibility, electron paramagnetic resonance and differential thermal analysis. The modified preparations based on the synthesized compounds and oxidized cellulose were prepared (gauze napkins of blue color). It has been established that the modification has a general toxic and hemolytic effect when injecting into isolated blood of experimental animals and they do not have irritating effect or allergic properties. An effective dose of the immobilized preparation was determined by the method of bacteriolytic activities. The prepared napkins do not cause local hyperemia for 24 hours. The possibility of their use as medical bandaging materials in surgical practice, urology, gynecology and anti-burn centers has been established.

LUBRICANT COMPOSITION FOR INCREASING WEAR RESISTANCE OF HEAVY-LOADED FRICTION PAIRS

The proposed new lubricating composition, which significantly reduces the wear resistance of the rails and wheels of rolling stock during operation, prevents electrochemical corrosion of friction pairs “wheel – rail” and, most importantly, stabilizes the coefficient of friction at the optimum level after a relatively short operating time. The experiments performed on the friction pair “sample of the bandage material of the railway wheel – a sample of the rail material” at the ratio of hardness at the bandage material (Rockwell hardness, HRC scale - 35.3) to the hardness of the rail material 1,1. Test results show that in the case of industrial lubricant, the BioRail brand, with the addition of nanomaterial friction pair with lower wear hardness of the rail metal sample after three hours in operation was practically not observed. Moreover, the average value of the friction coefficient for three hours of operation had been maintained at the level 0.25, which is optimal for the friction pair “wheel – rail”.

Synthesis of Chitosan-Based Gold Nanoparticles: Antimicrobial and Wound-Healing Activities.

The global spread of multidrug-resistant bacteria has become a significant hazard to public health, and more effective antibacterial agents are required. Therefore, this study describes the preparation, characterization, and evaluation of gold nanoparticles modified with chitosan (Chi/AuNPs) as a reducing and stabilizing agent with efficient antimicrobial effects. In recent years, the development of an efficient and ecofriendly method for synthesizing metal nanoparticles has attracted a lot of interest in the field of nanotechnology. Colloidal gold nanoparticles (AuNPs) were prepared by the chemical reduction of gold ions in the presence of chitosan (Chi), giving Chi/AuNPs. The characterization of Chi/AuNPs was carried out by transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier-transform infrared (FTIR), and X-ray diffraction (XRD). Chi/AuNPs appeared spherical and monodispersed, with a diameter ranging between 20 to 120 nm. The synergistic effects of AuNPs and Chi led to the disruption of bacterial membranes. The maximum inhibitory impact was seen against P. aeruginosa at 500 µg/mL, with a zone of inhibition diameter of 26 ± 1.8 mm, whereas the least inhibitory effect was reported for S. aureus, with a zone of inhibition diameter of 16 ± 2.1 mm at the highest dose tested. Moreover, Chi/AuNPs exhibited antifungal activity toward Candida albicans when the MIC was 62.5 µg/mL. Cell viability and proliferation of the developed nanocomposite were evaluated using a sulphorhodamine B (SRB) assay with a half inhibitory concentration (IC50) of 111.1 µg/mL. Moreover, the in vitro wound-healing model revealed that the Chi/AuNP dressing provides a relatively rapid and efficacious wound-healing ability, making the obtained nanocomposite a promising candidate for the development of improved bandage materials.

Increasing Wear Resistance of Heavy-Loaded Friction Pairs by Nanoparticles in Conventional Lubricants: A Proof of Concept

This paper provides experimental data on the effective use of a new lubricating composition, which includes industrial oil of any brand with the addition of a nanometal of the component of a friction pair, which has a lower hardness. It is shown that this composition significantly reduces the wear resistance of the rails and wheels of rolling stock during operation, prevents electrochemical corrosion of the friction pair wheel–rail and, most importantly, stabilizes the coefficient of friction at the optimum level after a relatively short operating time. The experiments were performed on the friction pair, “sample of the bandage material of the railway wheel—a sample of the rail material”, with a ratio of hardness of the bandage material (Rockwell hardness, HRC scale—35.3) to the hardness of the rail material of 1.1. Test results show that in the case of industrial lubricant, the BioRail brand, with the addition of a nanomaterial friction pair with lower wear hardness of the rail metal sample, after three hours in operation the wear was practically not observed. Moreover, the average value of the friction coefficient for three hours of operation was maintained at the level 0.25, which is optimal for the friction pair wheel–rail. Similar experiments using only the same lubricant brand showed much worse results.

Acellular fish skin grafts for the management of wounds in dogs and cats: 17 cases (2019-2021).

To report the clinical outcomes of the use of acellular fish skin grafts (FSGs) for the management of complex soft tissue wounds of various etiologies in dogs and cats. 13 dogs and 4 cats with complex wounds treated with FSGs between February 2019 and March 2021. Medical records were reviewed for information regarding cause, location, size of the wound, management techniques, complications, and clinical outcomes. In dogs, the number of FSG applications ranged from 1 to 4 (median, 2 graft applications). The time between each application ranged from 4 to 21 days (median, 9.5 days). Time to application of the first FSG ranged from 9 to 210 days (median, 19 days). Wounds closed by second-intention healing following the first fish skin application between 26 and 145 days (median, 71 days; n = 12). In cats, 1 or 2 FSGs were used, and the wounds of 3 of 4 cats healed completely by secondary intention. The wounds of 1 dog and 1 cat did not heal. There were no adverse events attributed to the use of the FSGs. For dogs and cats of the present study, complete healing of most wounds occurred with the use of FSGs, the application of which did not require special training, instruments, or bandage materials.

Antibacterial effect of electrospun polyurethane-gelatin loaded with honey and ZnO nanoparticles as potential wound dressing

Damage to the skin makes the body vulnerable to microorganisms; wound dressings with desirable properties such as antibacterial activity is used in order to accelerate the healing of the injury. An available natural substance investigated for its antibacterial property is honey; also, zinc-oxide nanoparticles (ZnO-NPs) have shown great antibacterial activities. This study investigated some properties of PU-Gel nanofibrous membranes, loaded with honey and ZnO-NPs, including antibacterial activity against Staphylococcus aureus, Escherichia coli, and Bacillus subtilis, mechanical properties and cell proliferation. The results indicate that PU/Gel/ZnO and PU/Gel/ZnO/H are suitable in inhibiting bacterial growth compared with PU/Gel/H and control membranes. Moreover, PU/Gel/H membranes had considerable antibacterial effect on E-coli. The addition of ZnO-NPs improved the mechanical properties. Cell culture studies (MTT test) proved the biocompatibility of the developed nanofibrous membranes. The obtained nanofibrous membrane PU/Gel/ZnO/H is a promising candidate for the development of improved bandage materials.

In Vivo Observation of Lidocaine-Encapsulated Polymyxin/Glycol Nanoparticles Wound Dressing for the Treatment and Care of Abdominal Pain Incision in Intensive Care Unit

The developments of lidocaine chloride loaded nanoparticles are encouraging biomaterials, which could be used for wound healing applications for abdominal pain management. The current work presents the composition of wound dressings based on lidocaine chloride (LCH) (anesthetic drug)-loaded Polymyxin (PMN)/Glycol (GLY). The LCH nanocomposite (LCH@PMN/GLY) were fabricated by the LCH oxide solutions within the PMN/GLY matrix. The influences of different experimental limitations on PMN/GLY nanoparticles formations were examined. The PMN/GLY and LCH@PMN/GLY nanoparticle sizes were evaluated by high resolution-scanning electron microscopy (HR-SEM). Additionally, the antibacterial efficacy of PMN/GLY and LCH@PMN/GLY was developed for gram-positive and negative microorganisms. Moreover, we examined in vivo healing of skin wounds formed in mouse models over 20 days. In contrast to the untreated wounds, rapid healing was perceived in the LCH@PMN/GLY-treated wound with less damage. These findings indicate that LCH@PMN/GLY-based bandaging materials could be a potential innovative biomaterial for tissue repair and implantation and nursing care for wound healing applications for abdominal pain incision in intensive care unit (ICU) management in an animal model.

Engineering of cerium oxide loaded chitosan/polycaprolactone hydrogels for wound healing management in model of cardiovascular surgery

This study was designed to establish the composition of wound bandages based on Cerium nanoparticle (CeNPs)-loaded chitosan (CS)/polycaprolactone (PCL). The CeNPs hydrogel (Ce-CS/PCL) was fabricated by the Cerium oxide solutions within the CS/PCL matrix. The influences of different experimental limitations on CS/PCL hydrogel formations were examined. The hydrogel particle sizes were evaluated by transmission electron microscopy and determined to range from ∼10−50 nm. The cumulative drug release profile of the Cerium from the bandage was found to be ∼38 % of the total loading after two days. Additionally, antibacterial efficacy was developed for gram positive and negative microorganisms. Moreover, we examined in vivo healing of skin wounds formed in mouse models over 24 days. In contrast to the untreated wounds, rapid healing was perceived in the Ce-CS/PCL-treated wound with less damaging. These findings indicate that Ce-CS/PCL-based bandaging materials could be a potential candidate for wound healing care management applications in cardiovascular surgery in the future.

Precise engineering of silver loaded polyvinyl alcohol nanogels for wound nursing care systems in operation room

This study was designed to establish the composition of wound bandages based on silver nanoparticle (AgNP)loaded polyvinyl alcohol (PVA) nanogels. The AgNP nanogel (Ag-nGel) was fabricated by the fructose-mediated reduction of silver nitrate solutions within the PVA matrix. The influence of different experimental limitations on PVA nanogel formations were examined. The nanogel particle sizes were evaluated by transmission electron microscopy and determined to range from ∼10–50 nm. Additionally, glycerol were added to the Ag-nGels, and the resulting compositions (Ag-nGel-Glu) were coated on cotton fabrics to generate the wound bandaging composite. The cumulative drug release profile of the silver from the bandage was found to be ∼38% of the total loading after two days. Additionally, antibacterial efficacy was developed for gram positive and negative microorganisms. Moreover, we examined in vivo healing of skin wounds formed in mouse models over 21 days. In contrast to the untreated wounds, rapid healing was perceived in the Ag-nGel-Glu-treated wound with less damaging. These findings indicate that Ag-nGel-Glu-based bandaging materials could be a potential candidate for wound bandaging applications in the future.

Antibacterial Activity of Honey/Chitosan Nanofibers Loaded with Capsaicin and Gold Nanoparticles for Wound Dressing.

This paper describes the preparation, characterization, and evaluation of honey/tripolyphosphate (TPP)/chitosan (HTCs) nanofibers loaded with capsaicin derived from the natural extract of hot pepper (Capsicum annuum L.) and loaded with gold nanoparticles (AuNPs) as biocompatible antimicrobial nanofibrous wound bandages in topical skin treatments. The capsaicin and AuNPs were packed within HTCs in HTCs-capsaicin, HTCs-AuNP, and HTCs-AuNPs/capsaicin nanofibrous mats. In vitro antibacterial testing against Pasteurella multocida, Klebsiella rhinoscleromatis, Staphylococcus pyogenes, and Vibrio vulnificus was conducted in comparison with difloxacin and chloramphenicol antibiotics. Cell viability and proliferation of the developed nanofibers were evaluated using an MTT assay. Finally, in vivo study of the wound-closure process was performed on New Zealand white rabbits. The results indicate that HTCs-capsaicin and HTCs-AuNPs are suitable in inhibiting bacterial growth compared with HTCs and HTCs-capsaicin/AuNP nanofibers and antibiotics (P < 0.01). The MTT assay demonstrates that the nanofibrous mats increased cell proliferation compared with the untreated control (P < 0.01). In vivo results show that the developed mats enhanced the wound-closure rate more effectively than the control samples. The novel nanofibrous wound dressings provide a relatively rapid and efficacious wound-healing ability, making the obtained nanofibers promising candidates for the development of improved bandage materials.

Portable medicine chests and supply of medicines in Serbia from the 1830s to the mid-20th century: analysis of medicines list.

The first portable medicine chests appeared in Serbia immediately after liberation from Ottoman rule around 1830. The network of portable medicine chests grew very quickly and became the first effective public health method of supplying medicines and medical items to people living in cities without community pharmacies and to the rural population in villages. According to their purposes, three categories of portable medicine chests could be identified: Portable medicine chests owned by physicians or veterinarians in the cities, portable medicine chests established by the Department of Workers Health Insurance, and portable medicine chests of the Health Cooperatives that operated in the villages This paper analyzes all three types of portable medicine chests. We specifically examine the regulations concerning the management of portable medicine chests, their content, and supply chains of medicines from the third decade of the 19 th century through the first half of the 20th century. We conclude that portable medicine chests represent a specific type of pharmacy in the territory of Serbia that provided very effective medical service. The medicines in these pharmacies were handled and dispensed to patients by physicians not by pharmacists. Patent medicines, compounded medicines, sanitary items and bandage materials were dispensed as well. Future research is needed to ascertain if physicians who owned or worked with the portable medicine chests actually prepared and compounded simple preparations as they were specified in the laws.

Fabrication and characterization of starch-TPU based nanofibers for wound healing applications

Wound dressings have undergone continuous and substantial evolution over time. Modern bandage materials constitute of electrospun biopolymers that enable rapid and effective wound healing due to the high surface area to volume ratio of the electrospun nanofibers and their porous structure. In the present study, nanofibrous bandages, containing a blend of starch-thermoplastic polyurethane (TPU), were developed by using the electrospinning technique. The electrospun nanofibrous mats were subsequently crosslinked with varying concentrations of glutaraldehyde in order to increase their water stability and mechanical properties. The nanofibrous bandages were characterized for their structural properties using SEM, FTIR, TGA, DSC, as well as for their water retention ability, water vapor transmission rate (WVTR), tensile strength and blood clotting efficiency. Cytotoxicity of the bandages was evaluated using human dermal fibroblast cells. Furthermore, the extent of wound healing enabled by the nanofibrous bandage was ascertained using Sprague-Dawley rats. The results revealed that the starch-TPU nanofibrous bandages facilitated enhanced wound-healing, as compared to the traditional dressing material, such as the cotton gauze.

Disastrous Complications Following Rhinoplasty: Soft Tissue Defects

Rhinoplasty has become one of the most frequently performed worldwide aesthetic procedures thanks to the successful results obtained by plastic surgeons. In this study, soft tissue defects, encountered as an undesirable and fearsome complication following rhinoplasty, its causes and precautions are presented by authors. Eight patients operated between December 2015 and December 2018 were enrolled in this study. According to the causes of soft tissue defects observed following rhinoplasty; patients were examined in 5 groups consisting of excessive subcutaneous adipose tissue defatting, improper dissection plane, compression of cast, splint and strip materials, pressure applied to skin by cartilage grafts, and overresection. Herein, while subcutaneous excessive defatting and intense cigarette smoking was responsible of the necrosis in the first patient we defined, high pressure on skin due to tight bandaging or external splint materials lead to skin necrosis in our patients 2, 3, and 4. The 5th and 6th patients were candidates of a revision rhinoplasty; however, both resulted with necrosis probably by reason of inaccurate dissection and/or possible diminished vascularity by previous rhinoplasty operations. In the 8th patient, necrosis was observed due to the compression of the bulky autologous cartilage graft used in the skin. In conclusion, skin necrosis is a rare but bothersome complication of rhinoplasty. The importance of atraumatic techniques and appropriate dissection plane during the rhinoplasty operation as well as the importance of the effect and control of the postoperative applied splint and bandage materials is so obviously seen.

Thermo-switchable de novo ionogel as metal absorbing and curcumin loaded smart bandage material

Abstract Inspired by the limitations of polymeric gels, conceptualizing low molecular weight gelator to form hydrogel that changes its properties as well applications through external stimuli of choice have attracted the attention of scientific community in recent times. Herein we had designed long alkyl chain containing ester functionalized ionic liquid, 3-methyl-1-(hexadecyloxycarbonylmethyl)imidazolium bromide (C16EMeImBr) that through self-assembling in water forms ionogel at 8.80% (w/v) critical gelation concentration and physiological pH. Ionogel, physically appeared as opaque at 25 °C, transformed into transparent at ~50 °C temperature and was characterized for the microstructural arrangement through small angle neutron scattering (SANS) and small angle X-ray scattering (SAXS) techniques. The gel formation ability of the C16EMeImBr was investigated in various solvents, in their neat form as well as solvent-water composition mixture. The fibrillar opaque ionogel have been studied for their metal (cobalt and copper) absorbing properties. Curcumin loaded ionogel was used to fabricate compact cotton patch to open the new avenues in non-woven bandage material that can work on infected wounds. The structural configuration of the curcumin-based ionogel was further investigated through molecular dynamic simulation.

Electrospun polymer nanofibers for medical applications

Polymer nanofibers are currently of great interest in terms of their potential use in various technological processes, e.g. in the manufacture of textiles or membranes. These fibers are characterized by extraordinary properties such as high surface to volume ratio and high porosity. There are several methods of manufacturing nanofibers, but for reasons of simplicity, repeatability and low cost, electrostatic spinning is the most common. The article presents a review of the latest developments in the application of polymer nanofibers in medicine, including such issues as bandage materials, release of active substances and tissue engineering.