Synthesis of Cu(II) coordination compounds with 2-amino-2-hydroxymethyl-1,3-propanediol, their modification and bactericidal action

Abstract

The procedure for the synthesis of Cu(II) coordination compounds with 2-amino-2-hydroxymethyl-1,3-propanediol (TPIS, NH2C(CH2OH)3) of various types: protonated [Cu(TRIS)2]SO4, partially deprotonated [Cu(TRIS2–H)H2O]ClH2O and intracomplex [Cu(TRIS–Н)2]5Н2О has been developed. Elemental analysis of the compounds obtained was carried out and their solubility, pH and conductivity of their solutions were determined. The synthesized compounds were studied by means of electron and IR-spectroscopies, magnetic susceptibility, electron paramagnetic resonance and differential thermal analysis. The modified preparations based on the synthesized compounds and oxidized cellulose were prepared (gauze napkins of blue color). It has been established that the modification has a general toxic and hemolytic effect when injecting into isolated blood of experimental animals and they do not have irritating effect or allergic properties. An effective dose of the immobilized preparation was determined by the method of bacteriolytic activities. The prepared napkins do not cause local hyperemia for 24 hours. The possibility of their use as medical bandaging materials in surgical practice, urology, gynecology and anti-burn centers has been established.