Abstract
The developments of lidocaine chloride loaded nanoparticles are encouraging biomaterials, which could be used for wound healing applications for abdominal pain management. The current work presents the composition of wound dressings based on lidocaine chloride (LCH) (anesthetic drug)-loaded Polymyxin (PMN)/Glycol (GLY). The LCH nanocomposite (LCH@PMN/GLY) were fabricated by the LCH oxide solutions within the PMN/GLY matrix. The influences of different experimental limitations on PMN/GLY nanoparticles formations were examined. The PMN/GLY and LCH@PMN/GLY nanoparticle sizes were evaluated by high resolution-scanning electron microscopy (HR-SEM). Additionally, the antibacterial efficacy of PMN/GLY and LCH@PMN/GLY was developed for gram-positive and negative microorganisms. Moreover, we examined in vivo healing of skin wounds formed in mouse models over 20 days. In contrast to the untreated wounds, rapid healing was perceived in the LCH@PMN/GLY-treated wound with less damage. These findings indicate that LCH@PMN/GLY-based bandaging materials could be a potential innovative biomaterial for tissue repair and implantation and nursing care for wound healing applications for abdominal pain incision in intensive care unit (ICU) management in an animal model.
Highlights
Infections cause problems in the field of wound management because they form exudates and limit wound improvement, leading to the use of inappropriate sponges
In our effort to introduce a tissue treating method, we have developed lidocaine chloride (LCH)@PMN/GLY bandage material based on PMN/GLY conjugated with LCH, which was first tested for tissue regeneration care management, to the best of knowledge
Our study aimed at developing novel wound bandages by covering double nanocomposite loaded with LCH on the surface of cotton fabrics
Summary
Infections cause problems in the field of wound management because they form exudates and limit wound improvement, leading to the use of inappropriate sponges. Microorganisms are the main cause of infections [1,2,3,4]. The most common infection-producing microorganisms are E. coli and Klebsiella, which are gram-negative bacteria. On entering the human body, these microorganisms quickly establish colonies. These organisms can penetrate the cell nanocomposite in the body, and enter the actual fractions of tissues and cells, leading to internal infections. Wound dressings are required to prevent these bacterial infections [5,6,7,8]
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