The effects of isocapnic hyperventilation (A) and normoventilation (B) on Pa co 2, Pa o 2 and a-aD o 2 were compared in 102 patients undergoing elective surgery, randomized into two comparable groups A and B. Cases for thoracic, high abdominal and intracranial surgery were excluded, as well as patients with clinically evident pulmonary pathology. A volumetric ventilator was used in association with three different breathing systems (A : Bain system and circle system without CO 2 absorption; B : circle system with CO 2 absorption). The groups were comparable, except for percentage of overweight : 75 % in group A and 56 % in group B. Overweight was defined as weight above the mean ideal weight of 100 %, and obesity as a weight above 120 % the mean ideal weight. Blood gases were sampled 1) preoperatively, 2) 15 min and 3) 60 min after the beginning of mechanical ventilation, 4) postoperatively, 90 min after extubation, without supplemental oxygen. The preoperative mean Pa o 2 values were 79±11.4 mmHg (A) and 82.5±13.2 mmHg (B); the Pa co 2 were 37.2±3.7 mmHg (A) and 37.2±3.8 mmHg (B). During surgery, Pa o 2 was distinctly higher (p <0.01) in group A than in group B (on average 15–20 mmHg higher), indicating the favourable effect of great tidal volumes on gas exchange. Correspondingly, the a-aD o 2 was less increased in group A than in group B (p <0.01). At 15 min, 33 % of the patients were hypocapnic (Pa co 2 <35 mmHg) : one case in group A and three in group B could be classed as severe hypocapnia (Pa co 2 = 25–30 mmHg). Hypocapnia tended to become more pronounced with time in group A but not in group B (p <0.05); this is explained by the higher proportion of overweights in group A. The postoperative Pa co 2 and Pa o 2 were comparable in both groups, and showed no significant difference with the preoperative values. The larger tidal volumes did not seem to have any residual protective effect on the postoperative Pa o 2. There were 25 cases of postoperative hypoxaemia (Pa o 2 <65 mmHg), without a significant difference between the two groups; they were significantly (p <0.05) related to overweight, even of moderate importance. There was no relationship with age greater than 60 years or with smoking. No patient suffered pulmonary complications during the four days following surgery. The effects of isocapnic hyperventilation on the Pa o 2 and the a-aD o 2, obvious during the operative period, did not persist in the early postoperative period (90 min after extubation). In view of certain disadvantages of this ventilation technique (high costs, environmental pollution, risks of barotrauma and of cardiovascular instability), it is recommended that controlled ventilation with physiological tidal volumes using a system with CO 2 absorption be used in patients undergoing elective surgery who do not have any pulmonary pathology associated with an increased a-aD o 2. Another relative indication for the Bain circuit is surgery, where the limited bulk of this system is useful (mainly head and neck surgery).
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