Background: Burnout and presenteeism are two emerging occupational health challenges which share same locus among healthcare workers, and the trend is rising. We aim to define the magnitude of burnout and presenteeism among frontline members of the health workforce and explore any correlation between the two in order to provide empirical data from our socioeconomic and geographical background.Design and Methods: We used self-administered questionnaire to conduct a cross-sectional study among the physicians and nurses in a regional trauma centre in Enugu, Eastern Nigeria; with the respondents selected by stratified random sampling. The Oldenburg burnout inventory and Stanford presenteeism scale were used to measure burnout and presenteeism respectively, while the 2-item patient-health questionnaire (PHQ-2) was used to screen for depression. The level of statistical significance was determined by a p value of <0.05.Results: Among the healthcare workers surveyed (n=155); 34 (21.9%) were physicians, while 121 (78.1%) were nurses. Burnout prevalence was 69%. Burnout was associated with self-rated health status and length of years in professional service but not the occupation or depression screen status of the worker. Sixty-two healthcare workers (40%) screened positive for depression. A positive screen for depression was the only factor that had significant association with lower presenteeism scores (p=0.002). The mean presenteeism scores had strong negative correlation with both the exhaustion (p<0.001) and disengagement (p<0.001) domains of burnout.Conclusion: Burnout is high among the healthcare workers and correlates with presenteeism scores. The mental health of the workforce greatly impaired their productivity.Significance for public healthDespite the high prevalence of burnout and presenteeism among healthcare workers their impact on the productivity of the workforce has not received adequate attention. Much of the work on burnout and presenteeism has been directed at their prevalence and associated demographics, while a few addressed their potential for direct harm or suboptimal care to patients. However, these earlier research perspectives provide insufficient resource for health economists and public health administrators. Accordingly, we chose to explore the relationship between the twin problems of high burnout and presenteeism among healthcare workers and their impact on productivity. We have reported our finding of an inverse correlation between burnout domains and productivity of the health workers. Furthermore, the revelation of 40% positive screen for depression raises serious concern regarding the mental health of the healthcare providers as it portends grave public health implications for themselves and the patients they cater for.