Background: Helicobacter pylori (H. pylori) expressed outer membrane proteins (OMPs) that assist in bacterial adherence to the gastric epithelium promoting successful colonization. One of these OMPs is the blood group antigen binding adhesin A (BabA) which bind to the fucosylated Lewis b blood group antigen (Le b ) on the surface of gastric epithelial cells. Another OMPs is the sialic acid binding adhesin (SabA) that mediates H. pylori binding the specific sialyl dimeric Lewis x glycosphingolipid (Le x ) on the gastric epithelium. A lot of discrepancies about the correlation between the presence of both babA and sabA genes and the apparent clinical outcome of H. pylori infection were reported. Objectives: The present study was to disclose the relationship between the presence of these genes and the clinical outcomes in Egyptian H. pylori patients. Methodology: Forty three H. pylori strains were isolated from patients with different clinical findings. Polymerase chain reaction (PCR) for detecting the presence of babA and sabA genes was performed using different sets of primers for detecting different regions of the gene. Further bioinformatics analysis for the sabA product was done using KEGG and Pfam websites. Results: evincing striking correlation between sabA presence and the gastric cancer disease. However, we could not find any correlation between presence of babA and the associated diseases. Conclusions: SabA is one of the H. pylori OMPs adhesins involving in increasing the risk of H. pylori associated gastric cancer in H. pylori Egyptian patients.