Β-acetamido Carbonyl Compounds Research Articles

Synthesis of Mannich type products via a three-component coupling reaction

The reactions of alkyl nitriles, acetyl chloride, aldehydes and β-ketoesters or simple ketones was studied for the one-pot synthesis of β-acetamido carbonyl compounds. It was observed that the reaction proceeds in the absence of Lewis acids. However, a Lewis acid catalyzes the reaction and several were tested. It was found that whereas Cu(OTf) 2 is suitable for the coupling of β-ketoesters with aldehydes, Sc(OTf) 3 is the best for ketones. A possible mechanism is proposed based on the isolation and characterization of an intermediate.

Cobalt‐Catalyzed One‐Pot Three‐Component Coupling Route to β‐Acetamido Carbonyl Compounds: A General Synthetic Protocol for γ‐Lactams.

AbstractFor Abstract see ChemInform Abstract in Full Text.

Cobalt catalyzed multiple component condensation route to β-acetamido carbonyl compound libraries

A simple and general procedure for the synthesis of various β-acetamido carbonyl compounds by a cobalt catalyzed one pot multiple component condensation reaction involving ketones, aldehydes and acetonitrile is described. A library of twenty discrete β-acetamido carbonyl compounds with two or three functional group variation was prepared.