Abstract
The reactions of alkyl nitriles, acetyl chloride, aldehydes and β-ketoesters or simple ketones was studied for the one-pot synthesis of β-acetamido carbonyl compounds. It was observed that the reaction proceeds in the absence of Lewis acids. However, a Lewis acid catalyzes the reaction and several were tested. It was found that whereas Cu(OTf) 2 is suitable for the coupling of β-ketoesters with aldehydes, Sc(OTf) 3 is the best for ketones. A possible mechanism is proposed based on the isolation and characterization of an intermediate.
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