Involvement Of Axial Skeleton Research Articles

Extensive Nonosseous Tc-99m HDP Accumulation in B-Cell Malignant Lymphoma

Bone scintigraphy in patients with malignant lymphoma is a useful diagnostic procedure to evaluate axial and appendicular skeleton involvement. Accumulation of bone-seeking agents by lesions in the liver, spleen, kidneys, and lymph nodes are very rare in malignant lymphomas. The authors describe a case study with extensive soft tissue Tc-99m HDP accumulation with good correlation on Ga-67 scintigraphy.

“Solid” variant of aneurysmal bone cyst (extragnathic giant cell reparative granuloma) in the axial skeleton and long bones. A study of its morphologic spectrum and distinction from allied giant cell lesions

Giant cell reparative granuloma is generally considered to be a benign tumor-like bone lesion. Its involvement of axial skeleton and long bones is rare. Seven cases of extragnathic giant cell reparative granuloma (GCRG), which arose in the axial skeleton and long bones, were analyzed clinicopathologically and compared with allied lesions consisting of 31 cases of aneurysmal bone cyst (ABC) and 83 cases of giant cell tumor of bone (GCT). These occurred in patients ranging in age from 8-36 years; two were in the vertebrae; two, in the clavicles; one, in a rib; one, in the humerus; and one in the tibia. None of the patients with GCRG had a recurrence despite incomplete resection. Its skeletal distribution and average associated patient age were similar to those of ABC. Histologically, they were characterized by florid fibroblastic proliferation with osteoclast-like giant cell-rich areas, stromal hemorrhage, and newly formed bone or osteoid trabeculae. The histologic features could be found around either the characteristic aneurysmal cysts or sinuses, although they were lacking any large blood-filled spaces. The overlapping clinical and histologic features between GCRG and ABC and their similar biologic behavior represent related responses to an intraosseous hemorrhage. The authors prefer to use the term "solid variant of aneurysmal bone cyst" to describe this lesion.

Tuberculous Osteomyelitis Masked by Concomitant Staphylococcal Infection

A systematic and easily reproduced bone protocol was used over a 14-month period to evaluate bone histologically and by mycobacterial culture in patients with chronic osteomyelitis. On examination of 140 bone specimens, we found four patients with unsuspected tuberculous osteomyelitis whose diagnosis was obscured by a concomitant staphylococcal osteomyelitis. Three of the patients had axial skeleton involvement, and one had disease of the femur. No patient had a history of a positive skin test or of tuberculous disease, and none had coexistent pulmonary disease. The underlying granulomatous infection was initially revealed in one patient by histologic examination of bone and in three others only by mycobacterial culture of bone. Concomitant osseous tuberculosis should be excluded in patients with staphylococcal osteomyelitis. Evaluation using a bone protocol with histologic study and culture on Löwenstein-Jensen medium is effective in diagnosing occult osseous tuberculosis.

Hyperparathyroidism in the cat of probable primary origin

ABSTRACTA 12‐year‐old cat was presented with clinical signs of lethargy, reluctance to move and pain along the back. Radiological examination revealed multifocal, polyostotic lesions with particular involvement of axial skeleton. Pathological findings included bilateral parathyroid hyperplasia and fibrous osteodystrophy which indicated that the bone lesions were caused by hyperparathyroidism, that was probably primary in origin.