Axial Elements Research Articles

Elemgasem nubilus: a new brachyrostran abelisaurid (Theropoda, Ceratosauria) from the Portezuelo Formation (Upper Cretaceous) of Patagonia, Argentina

AbstractAbelisaurids are medium–large‐sized theropod dinosaurs that were predominant in the carnivorous fauna during the Late Cretaceous of Gondwana. These predators are abundant in the Cretaceous fossil strata of Patagonia, which yield the best record for this group. In the Late Cretaceous, abelisaurids appear in almost all regions of Gondwana and in all stages, except for the Coniacian, in which they are globally unknown. Here we describe a new abelisaurid,Elemgasem nubilusgen. et sp. nov., from the Portezuelo Formation (Turonian–Coniacian), Patagonia, Argentina. The palaeohistology of the appendicular bones ofElemgasemshows that the holotype was a subadult individual, but had achieved sexual maturity. This taxon is based on several axial and appendicular elements, and is diagnosed by the presence of a marked pattern of rugosity on the lateral surface of the fibula and a dorsoventrally deep lateral wall of the calcaneum. Moreover, the posterior caudal vertebrae have a morphology slightly different from any other abelisaurid.Elemgasem nubilusis recovered as an unstable taxon within Brachyrostra, given that it was recovered as sister taxon of Furileusauria or in several positions within this clade. Despite the problematic phylogenetic relationships ofElemgasem nubilus, it is important because it is the first abelisaurid from the Turonian–Coniacian interval and it increases the diversity of this theropod family at a time of marked turnover in the tetrapod fauna of South America, global climate change, and mass extinction events recorded worldwide in the marine realm.

A new early diverging thalattosuchian (Crocodylomorpha) from the Early Jurassic (Pliensbachian) of Dorset, U.K. and implications for the origin and evolution of the group

ABSTRACT Among archosaurs, thalattosuchian crocodylomorphs experienced the most extensive adaptations to the marine realm. Despite significant attention, the phylogenetic position of the group remains uncertain. Thalattosuchians are either the sister-group to Crocodyliformes, basal mesoeucrocodylians, or nest among longirostrine neosuchians. The earliest definite thalattosuchians are Toarcian, and already possess many synapomorphies of the group. All phylogenetic hypotheses imply a ghost lineage extending at least to the Sinemurian, and a lack of older or more plesiomorphic forms may contribute to the uncertain phylogenetic placement of the group. Here we describe a new species, Turnersuchus hingleyae, gen. et sp. nov., from the early Pliensbachian Belemnite Marl Member of the Charmouth Mudstone Formation (Dorset, U.K.). The specimen includes partially articulated cranial, mandibular, axial, and appendicular elements. It can be attributed to Thalattosuchia based on the following features: distinct fossa on the posterolateral corner of the squamosal; broad ventrolateral process of the otoccipital covering the dorsal surface of the quadrate; large supratemporal fenestrae lacking a flattened skull table; broadly exposed prootic; orbital process of quadrate lacking bony attachment with the braincase. This specimen represents the earliest thalattosuchian currently known from diagnostic material. Phylogenetic analyses of two published datasets recover Turnersuchus as the earliest diverging thalattosuchian, and sister to Teleosauroidea + Metriorhynchoidea. Bayesian tip-dating analyses suggest a Rhaetian or Sinemurian divergence of Thalattosuchia from other crocodylomorphs, depending on topology, with confidence intervals spanning from the Norian to the Pliensbachian. The new specimen extends the fossil record of Thalattosuchia, but the time-scaling analyses demonstrate that a significant ghost lineage remains.

Everything Stays the Same while Everything Changes

Everything Stays the Same while Everything Changes

Oil drag loss in oil-flooded, twin-screw compressors

Rotary twin screw compressors are widely used because of their high efficiency and reliability. Their most common mode of operation is as oil-flooded machines when delivering air and gases at moderate pressures and flow rates. In order to achieve the best performance, it is essential to be able to predict the optimum amount of oil, required for the oil injection process, accurately. Analytical procedures for the design and performance estimation of twin screw compressors are well developed and widely available, but the determination of oil drag losses, in oil-flooded machines is only guesstimated. This paper describes a more detailed and accurate procedure for estimating oil drag loss, using a combined Couette-Poiseuille flow model and gives the results of studies on three sizes of machines operating over a range of pressure ratios and speeds. To this end, a parametric analysis has been developed based on a combined Couette-Poiseuille flow model and has been used to estimate the individual effects of pressure ratio, the various clearances and the oil viscosity on the total drag loss, for different sizes of the compressor. It can be seen from the results that at pressure ratios of up to 8.5, the drag loss due to the discharge axial clearance gap is nearly 2/3rd of the total, while nearly 1/3rd is due to the radial clearance. At normal operating speeds, the loss due to the interlobe clearance is insignificant, but as the pressure ratio increases, this rises more rapidly than that due to the axial and radial losses. The gain in the drag loss due to greater oil viscosity becomes more significant as the compressor size is increased. In larger machines, when clearance values are increased, the radial and axial elements of the drag loss are reduced more rapidly than that due to the interlobe loss.

Axial load ratio and limit for ductility design of steel fiber-reinforced concrete composite shear walls

Serious compression failure of reinforced concrete shear walls under high axial load ratios can be effectively prevented by adding steel fibers at the bottom, combined with an imbedded steel profile in the boundary element. However, the existing axial load ratio limit for conventional reinforced concrete shear walls is not suitable for performance-based design of such composite structural member. The seismic behavior of three composite walls with different fiber volume fractions (0–2.0%) was investigated through experimental and numerical studies under the preliminarily determined axial load ratio limit. The influence of the axial load ratio and boundary element requirements on the displacement ductility was numerically quantified. Addition of fibers assisted in mitigating the crushing of bottom concrete, improving the displacement ductility, and maintaining the bearing capacity under large deformations. Subsequently, an axial load ratio limit relax of 0.1 to 0.2 was adopted for such walls with fiber volume fraction of 1.0% to 2.0% to obtain a displacement ductility consistent with traditional walls. Finally, the axial load ratio limit and corresponding requirements on boundary elements for such walls with separate ductility demand have been recommended, which can provide guidance for performance-based design of such composite walls with flexure-controlled failure mode, however, shear-controlled walls should also be investigated in further studies.

Functions and Regulation of Meiotic HORMA-Domain Proteins.

During meiosis, homologous chromosomes must recognize, pair, and recombine with one another to ensure the formation of inter-homologue crossover events, which, together with sister chromatid cohesion, promote correct chromosome orientation on the first meiotic spindle. Crossover formation requires the assembly of axial elements, proteinaceous structures that assemble along the length of each chromosome during early meiosis, as well as checkpoint mechanisms that control meiotic progression by monitoring pairing and recombination intermediates. A conserved family of proteins defined by the presence of a HORMA (HOp1, Rev7, MAd2) domain, referred to as HORMADs, associate with axial elements to control key events of meiotic prophase. The highly conserved HORMA domain comprises a flexible safety belt sequence, enabling it to adopt at least two of the following protein conformations: one closed, where the safety belt encircles a small peptide motif present within an interacting protein, causing its topological entrapment, and the other open, where the safety belt is reorganized and no interactor is trapped. Although functional studies in multiple organisms have revealed that HORMADs are crucial regulators of meiosis, the mechanisms by which HORMADs implement key meiotic events remain poorly understood. In this review, we summarize protein complexes formed by HORMADs, discuss their roles during meiosis in different organisms, draw comparisons to better characterize non-meiotic HORMADs (MAD2 and REV7), and highlight possible areas for future research.

Partial muon capture rates in A=3 and A=6 nuclei with chiral effective field theory

Searches for neutrinoless double-$\ensuremath{\beta}$ decay rates are crucial in addressing questions within fundamental symmetries and neutrino physics. The rates of these decays depend not only on unknown parameters associated with neutrinos, but also on nuclear properties. In order to reliably extract information about the neutrino, one needs an accurate treatment of the complex many-body dynamics of the nucleus. Neutrinoless double-$\ensuremath{\beta}$ decays take place at momentum transfers on the order of $100\phantom{\rule{0.28em}{0ex}}\mathrm{MeV}/c$ and require both nuclear electroweak vector and axial current matrix elements. Muon capture, a process in the same momentum transfer regime, has readily available experimental data to validate these currents. In this Letter, we present results of ab initio calculations of partial muon capture rates for $^{3}\mathrm{He}$ and $^{6}\mathrm{Li}$ nuclei using variational and Green's function Monte Carlo computational methods. We estimate the impact of the three-nucleon interactions, the cutoffs used to regularize two-nucleon $(2N)$ interactions, and the energy range of $2N$ scattering data used to fit these interactions.

Early Triassic ichthyopterygian fossils from the Russian Far East

Ichthyopterygia is a major clade of reptiles that colonized the ocean after the end-Permian mass extinction, with the oldest fossil records found in early Spathian substage (late Olenekian, late Early Triassic) strata in the western USA. Here, we describe reptilian remains found in situ in the early Spathian Neocolumbites insignis ammonoid zone of South Primorye in the Russian Far East. Specimen NSM PV 23854 comprises fragmentary axial elements exhibiting a combination of morphological characteristics typical of Ichthyopterygia. The cylindrical centra suggest that the specimen represents a basal ichthyopterygian, and its size is comparable to that of Utatsusaurus. Specimen NSM PV 24995 is represented by a single limb bone, which is tentatively identified as an ichthyopterygian humerus. With a body length of approximately 5 m estimated from the humeral length, NSM PV 24995 represents one of the largest specimens of early Spathian marine reptiles known to date. Such size variation among the earliest ichthyopterygians might suggest an explosive diversification in size immediately after the end-Permian mass extinction. Both vertebrae and humerus specimens exhibit an extremely cancellous inner structure, suggesting a high degree of aquatic adaptation in ichthyopterygians, despite their short history of evolution in the ocean.

The sex difference of the volume and surface area of the human axial skeleton.

We assessed the sex difference in the volume and surface area of the bone using three-dimensional bone models generated from computer tomography images of axial skeletal elements from 110 Korean cadavers. The volume and surface area of all bones were significantly different between females and males. The accuracy of sex determination ranged from 55.6%-93.7% in univariate discriminant function analysis, with the second thoracic vertebra showing the highest accuracy. In discriminant analysis using paired bone combinations, 22 combinations of bone volume and surface area yielded > 90% accuracy in sex determination. The highest accuracy in the stepwise analysis was 94.7% when using the surface area of the ribs, sternum, and vertebrae for determining sex. This result shows a higher or similar accuracy than previous metric and non-metric studies using the axial skeleton, however, it shows lower accuracy than previous study which used volume and surface area of the appendicular skeleton. Nevertheless, this method might have advantage that is possible to determine sex quickly due to base on the computation with medical images.

A new early branching armored dinosaur from the Lower Jurassic of southwestern China.

The early evolutionary history of the armored dinosaurs (Thyreophora) is obscured by their patchily distributed fossil record and by conflicting views on the relationships of Early Jurassic taxa. Here, we describe an early diverging thyreophoran from the Lower Jurassic Fengjiahe Formation of Yunnan Province, China, on the basis of an associated partial skeleton that includes skull, axial, limb, and armor elements. It can be diagnosed as a new taxon based on numerous cranial and postcranial autapomorphies and is further distinguished from all other thyreophorans by a unique combination of character states. Although the robust postcranium is similar to that of more deeply nested ankylosaurs and stegosaurs, phylogenetic analysis recovers it as either the sister taxon of Emausaurus or of the clade Scelidosaurus+ Eurypoda. This new taxon, Yuxisaurus kopchicki, represents the first valid thyreophoran dinosaur to be described from the Early Jurassic of Asia and confirms the rapid geographic spread and diversification of the clade after its first appearance in the Hettangian. Its heavy build and distinctive armor also hint at previously unrealized morphological diversity early in the clade's history.

Numerical Parametric Studies on the Stress Distribution in Rocks around Underground Silo

The underground silo was constructed as a facility for the disposal of low- and intermediate-level radioactive waste. It is divided into three parts: the upper-dome core, the lower-dome core, and the cylindrical-space core. Numerical parametric studies on the stress distribution occurring in the surrounding rocks around the underground silo are presented in this paper. It is assumed that the soil layer was distributed to a depth of −4.3 m from the ground level, the weathered rocks were distributed to a depth of −9.5 m from the bottom of the soil layer, and the rocks were distributed in the lower part of the weathered rocks. A 2D axial symmetric finite element model was considered for the numerical analysis of the underground silo. A 3D finite element model was used to verify the reliability of the 2D axial symmetric model. Finite element analysis was carried out under various ratios of in situ horizontal stress to vertical stress (Ko). The numerical results obtained through these analyses include detailed stress states in the p–q and octahedral planes at key locations of finite element models around an underground silo. Contours of safety factor distributions are also presented to evaluate the overall structural safety of the surrounding rock mass, which is the main supporting body of the underground silo.

BHLS_2 upgrade: tau spectra, muon HVP and the [pi ^0,~eta ,~{eta ^prime }] system

The generic hidden local symmetry (HLS) model has recently given rise to its hbox {BHLS}_2 variant, defined by introducing symmetry breaking mostly in the vector meson sector; the central mechanism is a modification of the covariant derivative at the root of the HLS approach. However, the description of the tau dipion spectra, especially the Belle one, is not fully satisfactory, whereas the simultaneous dealing with its annihilation sector (e^+ e^- rightarrow pi ^+ pi ^-/pi ^+ pi ^-pi ^0/ pi ^0 gamma /eta gamma /K^+ K^-/K_L K_S) is optimum. We show that this issue is solved by means of an additional breaking term which also allows us to consistently include the mixing properties of the [pi ^0,eta ,{eta ^prime }] system within this extended hbox {BHLS}_2 (hbox {EBHLS}_2) scope. This mechanism, an extension of the usual ’t Hooft determinant term, only affects the kinetic energy part of the hbox {BHLS}_2 Lagrangian. One thus obtains a fair account for the tau dipion spectra which complements the fair account of the annihilation channels already reached. The Belle dipion spectrum is found to provide evidence in favor of a violation of the conserved vector current (CVC) in the tau lepton decay; this evidence is enforced by imposing the conditions <0|J_mu ^q |[q^prime overline{q^prime }](p)>=ip_mu f_q delta _{q q^prime }, { [q {overline{q}}], q=u,d,s} on hbox {EBHLS}_2 axial current matrix elements. hbox {EBHLS}_2 is found to recover the usual (completed) formulae for the [pi ^0,~eta ,~{eta ^prime }] mixing parameters, and the global fits return mixing parameter values in agreement with expectations and better uncertainties. Updating the muon hadronic vacuum polarization (HVP), one also argues that the strong tension between the KLOE and BaBar pion form factors imposes to provide two solutions, namely a_mu ^{HVP-LO}(mathrm{KLOE})=687.48 pm 2.93 and a_mu ^{HVP-LO}(mathrm{BaBar})=692.53 pm 2.95, in units of 10^{-10}, rather than some combination of these. Taking into account common systematics, their differences from the experimental BNL-FNAL average value exhibit significance > 5.4sigma (KLOE) and > 4.1sigma (BaBar), with fit probabilities favoring the former.

The Axial Skeleton of Rinconsaurus caudamirus (Sauropoda: Titanosauria) from the Late Cretaceous of Patagonia, Argentina

Titanosaurs were the predominant herbivores during the Late Cretaceous, inhabiting all continents. This clade was especially diverse in South America with some of the largest and smallest sauropod species known to date. Despite its diversity, the evolution of this clade is far from being well-known, although some recent analyses have begun to find some consensus in their results. Rinconsauria (defined as the least inclusive clade containing Rinconsaurus and Muyelensaurus) includes small titanosaurs and is considered as closely related to the lineage of giant titanosaurs, Lognkosauria (defined as the least inclusive clade containing Futalognkosaurus and Mendozasaurus), both being part of the recently named clade Colossosauria. The titanosaur Rinconsaurus caudamirus, from the Bajo de la Carpa Formation (Santonian), Río Negro, Argentina, is represented by several axial and appendicular elements from at least four specimens. This taxon was only briefly described when it was named and most of its originally proposed autapomorphies are now recognized as having a more widespread distribution amongst titanosaurs. Herein we present a detailed osteological description of the axial skeleton and a revised diagnosis for this taxon that firmly establishes its validity. Based on comparisons with other titanosaurs, we found three new possible autapomorphies for the axial skeleton of Rinconsaurus, which added to its original combination of characters, endorsing this taxon as a valid genus. Besides, this revision of Rinconsaurus provides additional osteological data that will contribute to a better resolution of titanosaur phylogeny, contributing at the same time to our understanding of the clade Rinconsauria.

A Novel Three-Dimensional Computational Method to Assess Rod Contour Deformation and to Map Bony Fusion in a Lumbopelvic Reconstruction After En-Bloc Sacrectomy.

Introduction: En-bloc resection of a primary malignant sacral tumor with wide oncological margins impacts the biomechanics of the spinopelvic complex, deteriorating postoperative function. The closed-loop technique (CLT) for spinopelvic fixation (SPF) uses a single U-shaped rod to restore the spinopelvic biomechanical integrity. The CLT method was designed to provide a non-rigid fixation, however this hypothesis has not been previously tested. Here, we establish a computational method to measure the deformation of the implant and characterize the bony fusion process based on the 6-year follow-up (FU) data.Materials and Methods: Post-operative CT scans were collected of a male patient who underwent total sacrectomy at the age of 42 due to a chordoma. CLT was used to reconstruct the spinopelvic junction. We defined the 3D geometry of the implant construct. Using rigid registration algorithms, a common coordinate system was created for the CLT to measure and visualize the deformation of the construct during the FU. In order to demonstrate the cyclical loading of the construct, the patient underwent gait analysis at the 6th year FU. First, a region of interest (ROI) was selected at the proximal level of the construct, then the deformation was determined during the follow-up period. In order to investigate the fusion process, a single axial slice-based voxel finite element (FE) mesh was created. The Hounsfield values (HU) were determined, then using an empirical linear equation, bone mineral density (BMD) values were assigned for every mesh element, out of 10 color-coded categories (1st category = 0 g/cm3, 10th category 1.12 g/cm3).Results: Significant correlation was found between the number of days postoperatively and deformation in the sagittal plane, resulting in a forward bending tendency of the construct. Volume distributions were determined and visualized over time for the different BMD categories and it was found that the total volume of the elements in the highest BMD category in the first postoperative CT was 0.04 cm3, at the 2nd year, FU was 0.98 cm3, and after 6 years, it was 2.30 cm3.Conclusion: The CLT provides a non-rigid fixation. The quantification of implant deformation and bony fusion may help understate the complex lumbopelvic biomechanics after sacrectomy.

NUEVOS RESTOS DE REBAQUISÁURIDOS DESDE LA FORMACIÓN HUINCUL (CENOMANIANO MEDIO–TURONIANO TEMPRANO) DEL CENTRO DE LA CUENCA NEUQUINA, PATAGONIA, ARGENTINA

In the central Neuquén Basin, the Huincul Formation comprises thick successions of Upper Cretaceous fluvial deposits widely exposed at the south and north-west of Huincul High. The vertebrate fossil record from the Huincul Formation is very abundant, especially considering the saurischian dinosaurs, including several theropod (Mapusaurus, Taurovenator, Aoniraptor, Skorpiovenator, Ilokelesia, Gualicho, Overoraptor, Tralkasaurus, and Huinculsaurus) and sauropod specimens (Choconsaurus, Argentinosaurus, Cathartesaura, Limaysaurus, and the indeterminate rebbachisaurid MMCH-Pv-49). In this contribution, we describe new rebbachisaurid sauropod findings from the El Orejano locality (Neuquén Province, Argentina), where coarse sandstones outcrop referred to the lower section of the Huincul Formation. The new material includes three axial elements that we refer to Rebbachisauridae: a partial dorsal neural arch (MAU-Pv-EO-633), an incomplete dorsal vertebra (MAU-Pv-EO-634), and an almost complete caudal vertebra (MAU-Pv-EO-666). These new findings share different features with other members of that family, although show some morphological differences with other rebbachisaurid taxa, which suggest a more diversified fauna in the central Neuquén Basin than previously known, at least during the Cenomanian/Turonian interval. This record from the new fossiliferous locality of El Orejano allows us to improve our knowledge about the morphological diversity of the Rebbachisauridae during the early Late Cretaceous. Furthermore, it represents one of the most modern records of the family, adding new information on the last stages of the evolutionary history of rebbachisaurids.

The TERB1 MYB domain suppresses telomere erosion in meiotic prophase I.

SUMMARYThe meiosis-specific telomere-binding protein TERB1 anchors telomeres to the nuclear envelope and drives chromosome movements for the pairing of homologous chromosomes. TERB1 has an MYB-like DNA-binding (MYB) domain, which is a hallmark of telomeric DNA-binding proteins. Here, we demonstrate that the TERB1 MYB domain has lost its canonical DNA-binding activity. The analysis of Terb1 point mutant mice expressing TERB1 lacking its MYB domain showed that the MYB domain is dispensable for telomere localization of TERB1 and the downstream TERB2-MAJIN complex, the promotion of homologous pairing, and even fertility. Instead, the TERB1 MYB domain regulates the enrichment of cohesin and promotes the remodeling of axial elements in the early-to-late pachytene transition, which suppresses telomere erosion. Considering its conservation across metazoan phyla, the TERB1 MYB domain is likely to be important for the maintenance of telomeric DNA and thus for genomic integrity by suppressing meiotic telomere erosion over long evolutionary timescales.

Penicisteckins A-F, Isochroman-Derived Atropisomeric Dimers from Penicillium steckii HNNU-5B18.

Penicisteckins A-D (1-4), two pairs of atropodiastereomeric biaryl-type hetero- and homodimeric bis-isochromans with 7,5'- and 7,7'-linkages and a pair of atropodiastereomeric 2-(isochroman-5-yl)-1,4-benzoquinone derivatives [penicisteckins E (5) and F (6)], were isolated from the Penicillium steckii HNNU-5B18. Their structures including the absolute configuration were determined by extensive spectroscopic and single-crystal X-ray diffraction analysis and TDDFT-ECD calculations. Both the bis-isochromans and the isochroman/1,4-benzoquinone conjugates represent novel biaryl scaffolds containing both central and axial chirality elements. The monomer anserinone B (8) exhibited potent antibacterial activities against Staphylococcus aureus ATCC 29213 and methicillin-resistant Staphylococcus aureus with minimal inhibition concentration values ranging from 2 to 8 μg mL-1. Plausible biosynthetic pathways of 1-6 are proposed, which suggest how the absolute configurations of the isolates were established during the biosynthetic scheme.

Germline-Restricted Chromosome (GRC) in Female and Male Meiosis of the Great Tit (Parus major, Linnaeus, 1758).

All songbirds studied so far have a germline-restricted chromosome (GRC), which is present in the germ cells and absent in the somatic cells. It shows a wide variation in size, morphology, and genetic content between the songbird species. In this paper, we analyzed GRC behavior in female and male meiosis of the great tit, using immunolocalization of meiotic proteins and FISH with GRC-derived DNA probes. We found that, despite dozens of million years of independent evolution, the great tit GRC displays a striking similarity with the GRCs of two species of martins and two species of estrildid finches examined earlier. It was usually present in two copies in females forming recombining bivalent and in one copy in males forming a condensed heterochromatic body with dotted-like axial elements of the synaptonemal complex. We observed mosaicism for the GRC copy number in the female and male great tit. This indicates that one of the GRC copies might be passively lost during premeiotic germ cell divisions. After the meiotic prophase, the GRC was ejected from most male germ cells. The reverse and interspecies FISH with GRC-specific microdissected DNA probes indicates that GRCs of the great tit, pale martin, and zebra finch differ substantially in their genetic content despite similarities in the meiotic behavior.

Overview of the modified magnetoelastic method applicability

&lt;p class="Abstract"&gt;A requirement of axial force determination in important structural elements of a building or engineering structure during its construction or operational state is very frequent in technical practice. In civil engineering practice, five experimental techniques are usually used for evaluation of axial tensile forces in these elements. Each of them has its advantages and disadvantages. One of these methods is the magnetoelastic method, that can be used, for example, on engineering structures for experimental determination of the axial forces in prestressed structural elements made of ferromagnetic materials, e.g., prestressed bars, wires and strands. The article presents general principles of the magnetoelastic method, the magnetoelastic sensor layout and actual information and knowledge about practical application of the new approach based on the magnetoelastic principle on prestressed concrete structures. Subsequently, recent results of the experimental verification and the in-situ application of the method are described in the text. The described experimental approach is usable not only for newly built structures but in particular for existing ones. Furthermore, this approach is the only one effectively usable experimental method for determination of the prestressed force on existing prestressed concrete structures in many cases in the technical practice.&lt;/p&gt;

Multifarious Roles of Hidden Chiral-Scale Symmetry: “Quenching” gA in Nuclei

I discuss how the axial current coupling constant gA renormalized in scale symmetric chiral EFT defined at a chiral matching scale impacts on the axial current matrix elements on beta decays in nuclei with and without neutrinos. The “quenched” gA observed in nuclear superallowed Gamow–Teller transitions, a long-standing puzzle in nuclear physics, is shown to encode the emergence of chiral-scale symmetry hidden in QCD in the vacuum. This enables one to explore how trace-anomaly-induced scale symmetry breaking enters in the renormalized gA in nuclei applicable to certain non-unique forbidden processes involved in neutrinoless double beta decays. A parallel is made between the roles of chiral-scale symmetry in quenching gA in highly dense medium and in hadron–quark continuity in the EoS of dense matter in massive compact stars. A systematic chiral-scale EFT, presently lacking in nuclear theory and potentially crucial for the future progress, is suggested as a challenge in the field.