Introduction Artificial intelligence (AI) is inevitably going to impact healthcare including dentistry and will become an essential tool in medical diagnosis and decision-making. Dental professionals must be familiar with growing trends in dentistry such as AI and its future scope. Despite the positive developments in AI research, there are divergent perspectives on its benefits and risks among stakeholders. We intended to understand the knowledge, awareness, and perceptions of dental professionals towards AI and its applications in dentistry. Methods and Material A semi-structured, 25-item Google form questionnaire consisting of closed and open-ended questions was made and the link to answer the survey was circulated among postgraduate students, dental academicians, and practitioners across India in an online mode, and the responses were collected and analyzed. Results 83.3% of participants were aware of AI and its applications. Most of the participants understood the attributes, advantages, and disadvantages of AI. Interestingly 72% of participants agreed that they have witnessed AI being used in clinical practice and 92.7% agreed to use AI for diagnosis. 65.3% expressed concern over unemployment due to AI and 85% agreed that AI has ethical issues. Over 85% of participants agreed AI should be a part of the postgraduate dental curriculum. Conclusions We found that dental professionals are updated with AI technology and showed a willingness to adopt AI into dental practice. The participants lacked a deeper understanding of AI and concerned about the potential risk of unemployment resulting from AI and trusting AI alone in dental diagnosis. Keywords: Artificial intelligence, Cross-sectional survey, Dentist, Knowledge, Perceptions.