Resilience corresponds to one's ability to positively outcome while experiencing aversive situation. It may be linked with a disparity of coping strategies after a spinal cord-injury (SCI). After a recent work realized in a population without SCI, suggesting the influence of empathy and alexithymia, the aim of our work consisted in studying their relative contribution on resilience in a sample of SCI patients. The survey consisted in the French version of the Connor-Davidson resilience scale (CDRISC10), the interpersonal reactivity index (IRI), the Toronto-alexithymia-scale (TAS20), the Brief-cope scale (b-COPE), the Hospital anxiety-depression scale (HAD) and the sense of coherence scale (SOCS), administered to 17 SCI patients included in the French study QaliPREPS (qualitative analysis of SCI patients’ perception of a systematic medical follow-up). Mean scores for full scales and their respective dimensions were calculated. The correlations between the different constructs were analyzed and the predictors of resilience were highlighted on the basis of multiple linear regression studies. Mean scores calculated for anxiety/depression, adaptation, sense of coherence and resilience were comparable to those calculated for a sample of adults with no SCI. Resilience presented significant positive correlation with copying ability and empathy, and significant negative correlation with alexithymia. Our data suggested that two dimensions of alexithymia (i.e., difficulty to describe one's own emotions and externally oriented thinking) and one dimension of empathy (fantasy ability) are negative predictors of resilience. By contrast, three dimensions of empathy (perspective taking, empathic concern, personal distress) positively influenced the resilience. We present the first analysis of resilience predictors in SCI patients. However, our study is limited by the small number of patients included into the survey. It justifies a scaling up in order to increase the strength of our conclusions.