Numerical simulation was carried out on the transmission loss of the split-stream rushing exhaust muffler, and the accuracy of the simulation method was verified through experiments. Taking the transmission loss as the response value, the experiment was designed by using Box-Behnken module of Design Expert software. A mathematical regression model of transmission loss with experiment factors was established by using the Box-Behnken experimental design scheme, the experiment factors include the diameter of the interior pipe, the shape of the rushing hole, the center distance of the rushing hole, the cone angle of the interior pipe as well as the number of rushing holes, and the mathematical regression model's significance was tested. The response curvatures of second order interaction to the transmission loss by different variables were obtained and the interaction relationships among variables were analyzed. The results showed that the diameter of the interior pipe and the center distance of the rushing hole are the main factors that affect the transmission loss. The transmission loss increases with the increase of the diameter of the interior pipe. When the diameter of the interior pipe is between 70 mm and 80 mm, the transmission loss firstly increases and then decreases with the center distance of the rushing hole changes from Smin to Smax. When the diameter of the interior pipe is between 80 mm and 90 mm, the transmission loss decreases with the center distance of the rushing hole changes from Smin to Smax. The effect of the rushing hole shape on transmission loss is not significant. The transmission loss increases with the increase of the number of rushing holes, but the increase of transmission loss is not significant with the number of rushing holes changes from 4 to 6 groups. Taking the transmission loss as the optimization index, the better experimental condition was obtained. Compared to the not optimized muffler of the sample engine, the average transmission loss of the optimized muffler is increased by 48.70 % when the frequency is 0-1000 Hz, the average insertion loss of the optimized muffler is increased by 7.4 %. At inlet air velocity of 40 m/s, the pressure loss is reduced by 56.8 %.