Average Uric Acid Level Research Articles

Epidemiological Investigation of Renal Colic and Research on Intervention Measures in a Field Training Troop in Northwest China

Background: To understand the incidence of renal colic and pain index scores during field training (summer and autumn) of military personnel, and to formulate intervention measures. Methods: A total of 3,856 people were surveyed in the three foreign training years from 2016 to 2018. An epidemiological survey was conducted on the training time of foreign training troops in summer and autumn, the training environment, temperature changes, dietary structure, age, gender, water consumption, etc.; at the same time; For soldiers with renal colic caused by urolithiasis, the blood uric acid level, blood phosphorus, blood calcium and other biochemical indicators were detected, intervention treatment was carried out, and the stone specimens produced after the treatment were analyzed for the stone composition. Results: 49 cases of renal colic occurred in 3856 people. The average incidence of renal colic was 1.2%, and the visual analog score index of renal colic was average (8.2±1.8). Among them, 47 were males and 2 were females. The average age was (22±2.5) years, the average stone size was (0.6±0.2) cm, the average temperature was (38.5±7.2)°C, and the average water consumption was (2000±300) mL. In 2016, there were 17 cases of 1150 cases, and the incidence of renal colic was 1.4%; in 2017, 12 cases of 1,320 cases, the incidence of renal colic was 0.9%; in 2018, 14 cases of 1386 cases, the incidence of renal colic, 1.1%. The average uric acid level was (282±11) mmol/L, the average blood phosphorus (0.98±0.03) mmol/L, and the average blood calcium (2.63±0.08) mmol/L. 26 cases were cured by conservative treatment, 19 cases were cured by extracorporeal shock wave lithotripsy, and 4 cases were cured by ureteroscopy. Urinary stones are mainly composed of monohydrate and dihydrate calcium oxalate stones. Conclusion: The incidence of renal colic in the field stationed troops in the northwest arid area in summer and autumn and high temperature environment is mainly caused by ureteral stones. The symptoms can be relieved by conservative treatment such as spasmolysis, analgesia, and stone removal; conservative treatment is the main treatment method, ureteroscopy Treatment assistance, no obvious adverse events occurred.

Biochemical indicators and course of dermatosis in children with psoriasis depending on the body mass index

The aim. To study the effect of increased body weight in children with psoriasis on the indicators of the biochemical profile and the severity of the pathological process.Materials and methods. The indicators of the biochemical profile were studied in 108 children, namely: the level of total protein, total bilirubin, cholesterol, liver enzymes (ALT, AST, GGT), triglycerides and low density lipoproteins, creatinine, urea, uric acid (UA), depending on the mass index body (BMI). The research materials were statistically processed using parametric analysis methods using the STATISTICA 13.3 software (developed by StatSoft. Inc).Results. Lipid profile indices both in the group of children with normal BMI and in the group of children with increased BMI are within the reference values. Statistically significant differences were found between the average GGT level in the group of children with increased BMI compared with the indicators in the group of children with normal BMI and indicators in the children of the control group. Also, in children with increased BMI, the average UA level is statistically significant higher than in children of the control group and has direct moderate and significant correlations with indices of the severity of the pathological process. In children with increased BMI, psoriasis severity indices correlate with BMI: PGA (r=0.51, p<0,01) BSA (r=0.48, p<0,01), PASI at the beginning of treatment (r=0.41, p<0,05) and PASI at the end of treatment (r=0.67, p<0.001) and percentage of excess body weight: BSA (r=0.34, p<0,05), PASI at the end of treatment (r=0.67, p<0.001). In children with normal BMI, such correlations were not found

THE EFFECT OF BROKEN WATER LEAVES ON THE REDUCTION OF URIC ACID LEVELS IN URIC ACID SUFFERERS IN WONOSARI VILLAGE, SENORI DISTRICT, TUBAN DISTRICT

Uric acid is the result of purine metabolism in the body contained in the blood and urine. There are several ways to overcome uric acid, one of therapy herbal bay leaf. The purpose of this study to the influence of the water decoction of the leaves to decrease the levels of uric acid in patients with gout in the Village of Wonosari Kecamatan Senori Tuban Regency. The design used in this research is pre-experimental approach with one-group pretest-posttest design. This research was conducted in the Village of Wonosari Kecamatan Senori Tuban on December 15-23 May 2020. Population and sample in this study were all patients with gout in the Village of Wonosari Kecamatan Senori Tuban Regency a number of 37 people by using a sampling technique total sampling. While the instrument used is a tool checks the uric acid and checklist. Data analysis by using T-Test. The results of this research note that the average uric acid levels before the administration of water decoction of bay leaf is 7,549 mg/dl. While the average levels of uric acid after administration of water decoction of bay leaf is 5,616 mg/dl. Data analysis using T-Test obtained ρ = 0.000 < α = 0.05 so H1 is accepted meaning that there is the effect of water decoction of the leaves to decrease the levels of uric acid in patients with gout. Efforts of health workers so that uric acid levels decreased is to provide IEC about the use of water decoction of bay leaf as a treatment alternative in patients with gout.

Roma Ethnicity and Sex-Specific Associations of Serum Uric Acid with Cardiometabolic and Hepatorenal Health Factors in Eastern Slovakian Population: The HepaMeta Study.

Background: Health characteristics associated with uric acid (UA) in the Roma minority remain less well known. The study sought to determine the ethnicity- and sex-specific associations of serum UA with health factors in Eastern Slovakian Roma and non-Roma populations. Methods: Data from the comparative cross-sectional HepaMeta study conducted in Slovakia in 2011 were used. The study enrolled 452 Roma subjects (35.2% men) and 403 non-Roma individuals (45.9% men) aged 18–55 years. Results: All study parameters differed between the sexes in both the Roma and non-Roma participants (p < 0.05). UA was related to sex with odds ratio for female sex 0.873, 95% CI 0.853–0.893 (p < 0.0001) per 10-unit increase of UA. Average level of UA ± standard deviation was lower in Roma than in non-Roma (226.54 ± 79.8 vs. 259.11 ± 84.53 umol/L; p < 0.0001). The Roma population presented with greater levels of high-sensitivity C-reactive protein (hsCRP) (3.07 ± 4 mg/L vs. 1.98 ± 2.83 mg/L; p < 0.0001) and ferritin in Roma males (403.78 ± 391.84 vs. 302.67 ± 236.26 mg/L; p < 0.0001). Conclusions: Serum UA is sex- and ethnicity specific. Elevated levels of hsCRP and ferritin particularly in Roma males can reflect low-grade systemic inflammation and thus serve as a marker of an increased cardiovascular risk.

Pemeriksaan Glukosa, Kolesterol dan Asam Urat pada Masyarakat Peserta Car Free Day di Balai Pelatihan Kesehatan (Bapelkes) Kota Semarang

Symptoms of a disease can be prevented if routine health checks are done. Health checks can be carried out in public and private laboratories, or free checks conducted by health education institutions through community service activities. The implementation of community service is carried out by lecturers involving students of the Medical Laboratory Science at the Muhammadiyah University of Semarang. This community service activity was carried out on December 15, 2019 in front of the Semarang Health Training Center Office on December 15, 2019. The inspection method uses Point of Care testing (POCT). The results of the examination that the number of respondents with cholesterol levels above normal for women more than men, while glucose and uric acid levels above normal in men more than women. The average cholesterol, glucose, and uric acid levels for men were 224.2; 123.1; 4.8 mg/dL respectively, while for women is 194.5; 121.2; 6,0 mg/dL. The higher age (12 - 65 years), the average cholesterol level increases from 189 to 217.8 mg/dL (15.25%) and the average glucose level increase from 84.4 to 131.5 mg / dL (55.80%), while the average uric acid level decreases from 5.4 to 5.2 mg / dL (3.85%). The conclusions of the health inspection activity about the result of cholesterol, glucose, and uric acid levels can be used to check public health

Деякі ревматологічні показники у хворих із діабет-асоційованими остеоартритами

Наразі актуальною є проблема асоціації поширених ревматичних захворювань, таких як ревматоїдний артрит, остеоартроз та остеопороз із цукровим діабетом (ЦД). До теперішнього часу немає єдиного погляду на роль біохімічних та імунних чинників, які викликають ураження суглобів в умовах коморбідності. Метою даного дослідження була оцінка біохімічних ревматологічних показників у хворих на ЦД 1-го та 2-го типів із діабет-асоційованими остеоартритами. Матеріал і методи. У дослідженні взяли участь 105 пацієнтів, яких розподілили на групи за типом діабету, наявністю та ступенем діабетичної артропатії. Пацієнтам проводили діагностику артропатій за допомогою УЗД суглобів і ревмапроби імунотурбодиметричним методом. Результати. У групі пацієнтів із ЦД 1-го типу артропатію виявлено в 64,4% випадків, у групі із ЦД 2-го типу — у 80,0% (t=1,8; p=0,07). У хворих з артропатіями виявлено прямий кореляційний зв’язок стадії артропатії з чинниками «антистрептолізин» (r=0,33; p&lt;0,01), «ревматоїдний чинник» (r=0,26; p&lt;0,05) і «С-реактивний білок» (r=0,43; p&lt;0,001). Встановлено підвищення середнього рівня сечової кислоти зі збільшенням стадії артропатіїяк у групі з ЦД 1-го типу (F=4,4; p=0,009), так і в пацієнтів із ЦД 2-го типу (F=17,9; p&lt;0,001). Висновок. Отримані результати продемонстрували, що як найбільш чутливі діагностичні критерії у хворих із діабет-асоційованими остеоартритами можна рекомендувати використовувати рівень сечової кислоти в крові, ревматоїдного чинника та С-реактивного білка.

PERAN AIR REBUSAN DAUN SALAM (SYZGIUM POLYANTHUM) DALAM MENURUNKAN KADAR ASAM URAT

Background: Uric acid is a final product or a waste that is resulted from the metabolism of purines. A high level of uric acid (hyperuricemia) will cause several health problems, such as vascular inflammation, smooth muscle proliferation, and vascular lesion in kidneys. The syzygium polyanthum leaves contain bioactive substances that may affect the level of uric acid in blood.&#x0D; Objective: This study aimed to determine the influence of boiled water of syzygium polyanthum leaves to the changes of uric acid levels in the target area of Puskesmas Pandak 1 Bantul.&#x0D; Methods: This study employed pre- and post-test without control group design. The population consisted of all patients with hyperuricemia in the target area of Puskesmas Pandak 1 Bantul. Sample was selected with a concecutive sampling, gaining a total number of 24 respondents. Data were analyzed with the Wilcoxon test. The dose of boiled water of syzygium polyanthum leaves intake was 0.36g/ KgBW, once a day for 14 days.&#x0D; Result: This research showed that the boiled water of syzygium polyanthum leaves decreased hyperuricemia (uric acid levels), along with the significancy value of 0.009 (p &lt;0.05). At the pre-test time, the average level of uric acid reached 7.279 mg/dl, and after the treatment, it decreased to 6.76 mg/dl.&#x0D; Conclusion: This study has established evidence that the boiled water of syzygium polyanthum leaves is able to decrease hyperuricemia (uric acid level in blood).&#x0D; Keywords: Syzygium polyanthum, boiled water of syzygium polyanthum leaves, hyperuricemia

PERBEDAAN KADAR ASAM URAT PADA WANITA PERIMENOPAUSE DAN MENOPAUSE

Increased levels of uric acid will occur in women after menopause due to a decrease in estrogen hormones that play an important role in increasing urinary acid excretion through urine. The occurrence of deposition of uric acid continuously in the body so that the kidneys are not able to remove uric acid properly. This study aims to determine differences in uric acid levels in perimenopausal women and menopause at Sukamerindu Health Center Bengkulu City. This study includes comparative study, with cross sectional study design. The sampling technique was purposive sampling as much as 74 respondents, with 37 respondents perimenopause women and 37 respondents of menopause women. Data analysis used univariate and bivariate analysis using independent t test. The mean rate of uric acid levels in perimenopausal women was 5.02 mg / dL while mean menopausal uric acid level was 7.04 mg / dL and after statistical test using independent t test, p value 0.0001, which means p &lt;0, 05 then there are differences in uric acid levels in perimenopausal women and menopause at puskesmas sukamerindu city of Bengkulu. The average uric acid levels in menopausal women is higher compared with perimenopausal women so it is expected for menopausal women to maintain health and consume lots of mineral water so that uric acid does not accumulate in the body.

Serum uric acid levels in acute myocardial infarction

Background: Higher uric acid is a negative prognostic factor in patients with mild to severe heart failure. Studies have shown that there is a close correlation between serum uric acid concentration and Killip classification in patients of acute myocardial infarction and uric acid levels are higher in patients with higher Killips class.Methods: We studied 100 patients with acute myocardial infarction and compared with 100 controls. Serum uric acid level was measured on day 0, 3 and 7 of MI and results were analysed.Results: Average uric acid level in male cases was 5.6 and female cases was 5.2, male controls were 4.2 and female controls was 3.6. Females had a higher mortality when compared with male patients. One female died due to MI on day 0, one male and two females died on day 3 and four males and four females died on day 7. All patients who died had higher uric acid levels.Conclusions: Serum uric acid levels are higher in patients of acute myocardial infarction as compared to normal healthy persons. Serum uric levels increases in patients with higher Killip class. Combination of Killip class and serum uric acid level after acute myocardial infarction is a good predictor of mortality after acute myocardial infarction.

PERAN AIR REBUSAN DAUN SALAM (SYZGIUM POLYANTHUM) DALAM MENURUNKAN KADAR ASAM URAT

Background: Uric acid is a final product or a waste that is resulted from the metabolism of purines. A high level of uric acid (hyperuricemia) will cause several health problems, such as vascular inflammation, smooth muscle proliferation, and vascular lesion in kidneys. The syzygium polyanthum leaves contain bioactive substances that may affect the level of uric acid in blood.&#x0D; Objective: This study aimed to determine the influence of boiled water of syzygium polyanthum leaves to the changes of uric acid levels in the target area of Puskesmas Pandak 1 Bantul.&#x0D; Methods: This study employed pre- and post-test without control group design. The population consisted of all patients with hyperuricemia in the target area of Puskesmas Pandak 1 Bantul. Sample was selected with a concecutive sampling, gaining a total number of 24 respondents. Data were analyzed with the Wilcoxon test. The dose of boiled water of syzygium polyanthum leaves intake was 0.36g/ KgBW, once a day for 14 days.&#x0D; Result: This research showed that the boiled water of syzygium polyanthum leaves decreased hyperuricemia (uric acid levels), along with the significancy value of 0.009 (p &lt;0.05). At the pre-test time, the average level of uric acid reached 7.279 mg/dl, and after the treatment, it decreased to 6.76 mg/dl.&#x0D; Conclusion: This study has established evidence that the boiled water of syzygium polyanthum leaves is able to decrease hyperuricemia (uric acid level in blood).&#x0D; Keywords: syzygium polyanthum, boiled water of syzygium polyanthum leaves, hyperuricemia

Perbedaan Kadar Asam Urat Sebelum dan Setelah Pemberian Jeroan pada Tikus Putih

Background: The era of globalization has brought many changes to lifestyle and eating habits are not healthy in the community. High protein foods that contain lots of purines can cause hyperuricemia. The aim of this study was to determine differences in the uric acid levels of before and after given of offal in the mice.&#x0D; Method: A true experimental study with pretest-posttest control group design used 14 mice. Data collection from measurements in the uric acid levels in the blood of mice examined before and after given of offal chicken liver juice. Analysis of research data was used dependent of paired t-test with confidence level of 95% using SPSS.&#x0D; Result: An average uric acid level before gift of the offal is 3.41 mg/dL, and after to gift of the offal is 7.93 mg/dL. Uric acid levels after to given of offal increased by 4.52 mg/dL (56.99%). In analysis univariate showed differences between uric acid levels before and after to gift of offal chicken liver juice in the mice (p-value = 0.000).&#x0D; Conclusion: There are differences in uric acid levels before and after given of offal in the mice.

Trp64Arg (rs4994) polymorphism of β3-adrenergic receptor gene is associated with hyperuricemia in a Chinese male population

β3-Adrenergic receptor (β3-AR) gene is associated with insulin resistance and may affect serum uric acid levels. Our aim was to determine the possible association between β3-AR gene Trp64Arg polymorphism (rs4994) and hyperuricemia in a Chinese male population. A total of 410 hyperuricemic and 420 normouricemic male subjects were genotyped in this study. The genotypic and allelic frequencies were compared between the two groups. Body mass index (BMI), waist to hip ratio (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), serum uric acid, urea nitrogen, creatinine, triglyceride, total cholesterol, low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C) and fasting plasma glucose (FPG) were determined. The frequencies of CC genotype and C allele for Trp64Arg polymorphism were higher in hyperuricemic group than in normouricemic group (p<0.01 and p<0.05, respectively). In both hyperuricemic and normouricemic groups, subjects with mutated C allele of Trp64Arg polymorphism showed significantly higher average uric acid levels than TT genotype carriers (p<0.01 and p<0.01, respectively). Univariate and multivariate logistic regression showed that carrier of mutated C allele of Trp64Arg polymorphism was significantly associated with hyperuricemia occurrence (p=0.003, OR=1.587, 95% CI 1.175-2.145 and p=0.003, OR=1.676, 95% CI 1.051-3.617). Trp64Arg polymorphism was associated with hyperuricemia in a Chinese male population and should be an independent risk factor for hyperuricemia.

Uric acid a better scavenger of free radicals than vitamin C in rheumatoid arthritis.

Uric acid an endogenous aqueous antioxidant in normal humans is present in much higher concentrations than vitamin C and has been known to cover 2/3(rd) of the free radical scavenging capacity in plasma. In the present study average uric acid levels of patients of rheumatoid arthritis were found to be close to the normal individuals. A unique feature was observed after classifying the patients on the basis of the duration of suffering, the patients having longer duration of disease had least uric acid levels as compared to those suffering from relatively lesser period, similar trend was observed in the ascorbic acid estimations. The decline in uric acid values with progression of the disease was much more than what was observed in case of ascorbic acid suggesting the significant role of uric acid in scavenging of free radicals. Too much lowering of Uric Acid should be checked and vitamin C should be supplemented in diet for maintaining the balance between pro oxidant and antioxidant forces to check pro oxidant insult in rheumatoid arthritis.

Effects of Pharmacists' Consultation on Serum Uric Acid Level in Outpatients with Hyperuricemia.

As part of the pharmaceutical guidance program using drug history notebooks for each patient and drug information leaflets, we gave pharmaceutical guidance to 37 outpatients with hyperuricemia chosen at random who were administered allopurinol or benzbromarone. The effects of pharmaceutical guidance on patient adherence were evaluated using changes in the serum uric acid level. The patients who were given conventional verbal explanations and shown descriptions on the drug bag were classified as the control group. Those who were given pharmaceutical guidance according to the pharmaceutical guidance program were classified as the intervention group. The baseline uric acid level and the levels 1 and 6 months after the start of pharmacist consultations were determined. Any patients who had changes in their drug prescriptions which affected their uric acid level during the investigation period were excluded. Sixteen patients in the control group and 17 in the intervention group were included in this study. There were no differences in the average value or variance of serum uric acid concentration at the baseline between the 2 groups. However, the average uric acid level decreased significantly 1 month after the start of consultations in the intervention group, while it did not changed in the control group. In patients showing baseline uric acid levels over 7 mg/dL, the uric acid levels showed a significant reduction in all patients in the intervention group, while the changes were not significant in the control group. These results showed that the pharmaceutical guidance performed by pharmacists enhanced the patients' medication compliance, thus resulting in an improvement of hyperuricemia.

Serum uric acid in young mongoloids.

A highly significant increase (P {lt} .005) in average uric acid level was found in the blood serum of 25 mongoloids in the age range of 2 to 12 years, with a mean age of 6 years, when levels were compared with those in nonmongoloid, mentally retarded children. These data confirm our previou results with 40 mongoloids whose mean age was 23.7 years, and indicate that elevated uric acid levels are present throughout most of the life of these subjects.

Serum Uric Acid in Mongolism

A highly significant increase (P < .01) in average uric acid level was found in the blood serum of mongoloids when levels were compared with those in normal control subjects or nonmongoloid, mentally retarded subjects. The possible relationship of these findings to other abnormalities known to exist in mongolism is discussed.