Biochemical indicators and course of dermatosis in children with psoriasis depending on the body mass index

Elvina Murzina

doi:10.15587/2519-4798.2020.221120

Abstract

The aim. To study the effect of increased body weight in children with psoriasis on the indicators of the biochemical profile and the severity of the pathological process.Materials and methods. The indicators of the biochemical profile were studied in 108 children, namely: the level of total protein, total bilirubin, cholesterol, liver enzymes (ALT, AST, GGT), triglycerides and low density lipoproteins, creatinine, urea, uric acid (UA), depending on the mass index body (BMI). The research materials were statistically processed using parametric analysis methods using the STATISTICA 13.3 software (developed by StatSoft. Inc).Results. Lipid profile indices both in the group of children with normal BMI and in the group of children with increased BMI are within the reference values. Statistically significant differences were found between the average GGT level in the group of children with increased BMI compared with the indicators in the group of children with normal BMI and indicators in the children of the control group. Also, in children with increased BMI, the average UA level is statistically significant higher than in children of the control group and has direct moderate and significant correlations with indices of the severity of the pathological process. In children with increased BMI, psoriasis severity indices correlate with BMI: PGA (r=0.51, p<0,01) BSA (r=0.48, p<0,01), PASI at the beginning of treatment (r=0.41, p<0,05) and PASI at the end of treatment (r=0.67, p<0.001) and percentage of excess body weight: BSA (r=0.34, p<0,05), PASI at the end of treatment (r=0.67, p<0.001). In children with normal BMI, such correlations were not found

Highlights

Psoriasis is a potential multisystem disease with extradermal manifestations in many patients
According to the results of our study, published earlier [14], we found that biochemical parameters in children with psoriasis, despite compliance with age reference values, indicate the presence of uric acid metabolism and signs of liver cell membrane damage, as evidenced by elevated levels uric acid (UA) and gammaglutamyltransferase (GGT) compared with children in the
Indicators of lipid profile in children with psoriasis both in the group of children with normal body mass index (BMI) and in the group of children with elevated BMI are within the reference values, but the average levels of GGT and UA in the group of children with elevated BMI were statistically significantly higher than in the control group of children, and the average level of GGT in the group of children with elevated BMI was statistically significantly higher than in the group of children with normal BMI. 2

Summary

Introduction

Psoriasis is a potential multisystem disease with extradermal manifestations in many patients. Adult patients with psoriasis have many comorbidities that can affect the patient's general condition and reduce their quality of life, such as arthritis, cardiovascular disease, dyslipidemia, obesity, metabolic syndrome, and depression. It is believed that children with psoriasis may have the same comorbidity. A systematic review conducted in 2019 showed that psoriasis in children is not associated with concomitant metabolic and cardiovascular diseases, with the exception of overweight and obesity [8]. S. et al believe that children with psoriasis and obesity are more prone to dyslipidemia in the blood than children with psoriasis and normal weight [9]. Other studies confirm that all children with psoriasis should be screened for cardiovascular and metabolic comorbidities, given the predisposition to such conditions [9, 11, 12]

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Discussion

Conclusion