Average Percentage Research Articles

The epidemiology of acute pancreatitis in Tasmania over a 12-year period: Is this a disease of disadvantage?

BackgroundThe global incidence of acute pancreatitis (AP) is increasing, but little information exists about trends in Australia. This study aimed to describe incidence trends, along with clinical and socio-demographic associations, in the state of Tasmania over a recent 12-year period. MethodsThe study cohort was obtained by linking clinical and administrative datasets encompassing the whole Tasmanian population between 2007 and 2018, inclusive. Pancreatitis case definition was based on relevant ICD-10 hospitalization codes, or elevated serum lipase or amylase in pathology data.Age-standardised incidence rates were estimated, overall and stratified by sex, aetiology, and Index of Relative Socio-economic Disadvantage (IRSD). ResultsIn the study period, 4905 public hospital AP episodes were identified in 3503 people. The age-standardised person-based incidence rate across the entire period was 54 per 100,000 per year. Incidence was inversely related to IRSD score; 71 per 100,000 per year in the most disadvantaged quartile compared to 32 in the least disadvantaged. Biliary AP incidence was higher than that of alcohol-related AP, although the greatest incidence was in “unspecified” cases. There was an increase in incidence for the whole cohort (average annual percent change 3.23 %), largely driven by the two most disadvantaged IRSD quartiles; the least disadvantaged quartile saw a slight overall decrease. ConclusionThis is the first Australian study providing robust evidence that AP incidence is increasing and is at the upper limit of population-based studies worldwide. This increased incidence is greatest in socio-economically disadvantaged areas, meriting further research to develop targeted, holistic management strategies.

Trends in mortality from gastrointestinal, hepatic, and pancreatic cancers in the United States: A comprehensive analysis (1999-2020).

This study investigates temporal trends in gastrointestinal cancer-related mortality in the United States between 1999 and 2020, focusing on differences by sex, age, and race. We investigated the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research multiple causes of death database (Years 1999-2020) for gastrointestinal cancer-related mortality with a focus on the underlying cause of death. A total of 3 115 243 gastrointestinal cancer-related deaths occurred from 1999 to 2020. The overall age-adjusted mortality rate decreased from 46.7 per 100 000 in 1999 to 38.4 per 100 000 in 2020. The average annual percent change (AAPC) for the study period was -0.9% (95% CI: -1.0%, -0.9%, P < 0.001), with no significant difference in AAPC between the sexes but some difference between races and related to individual cancers. African Americans and Asian Americans, and Pacific Islanders experienced a greater decrease in mortality compared with Whites. Mortality rates for American Indian and Alaskan Native populations also decreased significantly from 1999 to 2020 (P < 0.001). There were significant declines in esophageal, stomach, colon, rectal, and gallbladder cancer-related mortality but increases in the small bowel, anal, pancreatic, and hepatic cancer-related mortality (P < 0.001), with variation across different sexes and racial groups. While overall gastrointestinal cancer-related mortality declined significantly in the United States from 1999 to 2020, mortality from some cancers increased. Furthermore, differences between sexes and racial groups underscore crucial differences in gastrointestinal cancer mortality, highlighting areas for future research.

Eastern Black Kingsnake Lampropeltis nigra dorsal scale colouration primarily adapted for thermoregulation

The Eastern Black Kingsnake Lampropeltis nigra exhibits variation in colouration and pattern throughout its range. Drivers behind this colour variation remain largely unknown. To elucidate patterns in the percentage of light pigmentation in L. nigra dorsal scales (% light) we compared two primary hypotheses. Our first hypothesis posited that L. nigra colouration has been adapted for thermoregulation (thermoregulation). Alternatively, we hypothesised that L. nigra colouration has been adapted to avoid detection by predators and prey (crypsis). To test our hypotheses, we modeled L. nigra % light from 46 counties within Mississippi as a function of average temperature, average maximum temperature (thermoregulation) and soil value (darkness of soil colour; crypsis). We included percentage forest cover as a modifying variable in the thermoregulation hypothesis and an interacting variable in the crypsis hypothesis. The best competing model included average temperature and percent forest cover as explanatory variables (LOOIC = -291.3, weight = 0.84, Bayesian R2 = 0.37 [fixed] and 0.55 [total]). There was a positive relationship between % light and average temperature (β = 0.23, 95% CIs = 0.13, 0.34) and average maximum temperature (β = 0.11, 95% CIs = -0.00, 0.21), and a negative relationship with percent forest cover (β = -0.14, 95% CIs = -0.23, -0.04). These results support the thermoregulation hypothesis. The climate in Mississippi, as in most of the world, is expected to experience shifts over the next century. If ambient temperatures experienced through these changes are outside of L. nigra’s thermal optima, as based on colour patterns and relationships observed in our study, then behavioural adaptations may result in some individuals experiencing thermal advantages that influence this species’ distribution. The patterns observed in our study, and expected changes in L. nigra behaviour and distribution, are likely to occur among other ectothermic species with relatively static colouration. Keywords: Colour adaptation, homeostasis, Mississippi

Knowledge about Fertility in Croatia, Measured with the Croatian Version of the Cardiff Fertility Knowledge Scale (CFKS-Hr), in Relation to Attitudes toward Having a Child and Associated Factors in a Cross-Sectional Survey.

Fertility is a crucial component of population maintenance and growth. A declining fertility trend has been observed over the past two decades, and it continues. The birth rate in the Republic of Croatia is continuously decreasing, which is insufficient to maintain its population. This research aimed to examine the level of fertility knowledge, factors influencing fertility knowledge, and the relationship between fertility knowledge and the decision to have a child. A cross-sectional study was conducted on a sample of mothers in five hospitals on the Adriatic coast of the Republic of Croatia, involving 1541 mothers, 18 years and older, from September 2021 to December 2023. The Cardiff Fertility Knowledge Scale (CFKS) was used for the research. The participants were divided into four groups according to age. The analysis was conducted using SPSS software (version 22.0). Descriptive statistics, chi-squared tests, t-tests, and Pearson's correlations were used for the data analysis. The average percent correct score on the CFKS was 51.8% (SD 22.6), with greater knowledge being significantly related to married status and higher education status (both p < 0.05). A total of 83% of mothers who have one child want to have more children. Fewer mothers who have two children want to have more children (42%), while only 11% of mothers who have three or more children want to have more children. There is no significant relationship between the CFKS and the importance of childbearing in the future (p = 0.12). Respondents indicated that they gained most of their knowledge from the internet (31%) and from the healthcare system (33%). The research results reveal a lack of fertility knowledge among participants, as well as an intention to have a child in the later stages of life. The lack of formal education on this topic leads to information gathering from friends, newspapers, television, and the internet. This study was not registered.

Infrared Fourier Transform Spectroscopy Method for Analysis of Valsartan and Amlodipine Besylate Combination

This study investigates the analysis of the combination of Valsartan and Amlodipine besylate using the Infrared Fourier Transform and its quantitative calculations by chemometrics based on partial least squares with several variables. A calibration model has been formulated, and absorbance besylate measurements at wave numbers of 1634-1566 cm-1 for valsartan and 1127-1059 cm-1 for amlodipine every 2.0 cm-1. Then simultaneously determine valsartan and amlodipine combined in the tablet preparation. The Infrared Fourier Transform method used for Amlodipine besylate and Valsartan with calibration are y = 13.1317 X -0.0595 and y = 129,731 X - 0.026. The validation parameters is 0.9995, and 0.9999 for R2 values, RMSCEV is 0.02427 and 0.003189, and PRESS is 0.02121 and 0.0003662. Prediction ability was still acceptable and good for determination. The levels result were (101.52±2.74)% and (98.47±5.71)%, and valid with Relative Standard Deviation (RSD) respectively 2%, and average recovery percent obtained in range of 98-102%. The method identified provided guaranteed compliance with USP 43-NF 38 (2020).

Patterns of immunotherapy utilization for non-small cell lung cancer in Texas pre- and post-regulatory approval.

Immunotherapy has shown remarkable benefits for non-small cell lung cancer (NSCLC) since approved by the US Food and Drug Administration (FDA). Texas, however, ranks below the national average in access to treatment for NSCLC. This retrospective cohort study assessed first-line immunotherapy treatment patterns and associated factors pre- and post-FDA approval in Texas. Patients ≥18years diagnosed with NSCLC from the Texas Cancer Registry database (2011-2018) and were stratified into pre- and post-FDA approval era. The rates of immunotherapy utilization were examined, and the average annual percent change (AAPC) in immunotherapy utilization across patient subgroups was compared. Multivariable logistic regression was used to identify associations of patient characteristics with immunotherapy utilization for patients with metastatic- and all-stage NSCLC. A total of 13,501 and 9509 patients with NSCLC were identified in pre-post-approval periods, respectively. Post-approval, immunotherapy utilization increased from 1.7 to 13.0%, and AAPC from 54.8 to 82.7%. Pre-approval, patients living in a county with ≥20% of households below the poverty level were less likely to receive immunotherapy (OR=0.73, 95% CI=0.61-0.94) while patients with private insurance were more likely to receive immunotherapy (OR=1.56, 95% CI=1.10-2.23). Post-approval, socioeconomic disparities were more prominent (10-19.9 and ≥20% of households below the poverty level: OR=0.77, 95% CI=0.66-0.90 and OR=0.71, 95% CI=0.60-0.86, respectively). Patients with metastatic NSCLC showed similar patterns of socioeconomic disparities pre- and post-approval. Our findings suggest that patients' socioeconomic status hinders immunotherapy utilization for NSCLC in Texas. This emphasizes the need for state health policy reforms such as Medicaid expansion and tailored cancer care strategies.

Trends in Adolescent Suicide by Method in the US, 1999-2020

Adolescent suicide in the US is a major public health problem, yet temporal trends in suicide methods by demographics are understudied. To examine national trends in suicide mortality by method (firearm, poisoning, hanging and asphyxiation, and all other means) from 1999 to 2020 by demographic characteristics. This serial cross-sectional study used national death certificate data of adolescent (aged 10-19 years) suicide decedents compiled by the National Center for Health Statistics from January 1, 1999, to December 31, 2020. Data analysis was performed from April 1, 2023, to July 9, 2023. Age, sex, and race and ethnicity. Trends in age-standardized mortality rates and average annual percent change (AAPC) in rates were estimated by age, sex, and race and ethnicity for each suicide method. This study assessed data from 47 217 adolescent suicide decedents. From 1999 to 2020, suicide by firearm (AAPC, 1.0; 95% CI, 0.1-1.9), poisoning (AAPC, 2.7; 95% CI, 1.0-4.4), hanging and asphyxiation (AAPC, 2.4; 95% CI, 0.2-4.6), and other means (AAPC, 2.9; 95% CI, 1.2-4.6) increased. Rapidly increasing rates were observed among female adolescents for poisoning (AAPC, 4.5; 95% CI, 2.3-6.7) and hanging and asphyxiation (AAPC, 5.9; 95% CI, 5.0-6.8) suicides. From 2007 to 2020, firearm suicides sharply increased among female (annual percent change [APC], 7.8; 95% CI, 6.0-9.5) and male (APC, 5.3; 95% CI, 4.3-6.3) adolescents. Firearm suicide rates increased among Black adolescents from 2012 to 2020 (APC, 14.5; 95% CI, 9.7-19.5), Asian and Pacific Islander adolescents from 2008 to 2020 (APC, 12.0; 95% CI, 9.7-14.5), American Indian and Alaska Native adolescents from 2014 to 2020 (APC, 10.6; 95% CI, 2.6-19.3), and Hispanic or Latino adolescents from 2011 to 2020 (APC, 10.2; 95% CI, 6.3-13.8). During the study period, Black adolescents had the highest average increase in hanging and asphyxiation suicides (AAPC, 4.2; 95% CI, 3.2-5.2). From 2011 to 2020, poisoning suicide deaths increased (APC, 12.6; 95% CI, 8.5-16.7) among female adolescents. Suicide rates increased across all methods from 1999 to 2020. Differences were noted by sex, age, and race and ethnicity. Increasing suicide rates among racial and ethnic minoritized youth are especially concerning, and effective prevention strategies are urgently needed.

Incidence of vestibular schwannoma in Finland, 1990-2017.

An increasing trend in incidence of vestibular schwannomas (VS) has been reported, though not consistently, across populations. Materials and methods: We obtained data from the Finnish Cancer Registry on 1,149 VS cases diagnosed in 1990-2017 with tabular data up to 2022. We calculated age-standardised incidence rates (ASR) overall, by sex, and for 10-year age groups. We analysed time trends using Poisson and joinpoint regression. The average ASR of VS in Finland during 1990-2017 was 8.6/1,000,000 person-years for women and 7.5/1,000,000 for men. A declining trend was found with an average annual percent change of -1.7% (95% confidence interval [CI]: -2.8%, -0.6%) for women, -2.2% (95% CI: -3.6%, -0.7%) for men, and -1.9% (95% CI: -2.9%, -1.0%) for both sexes combined. The ASR in women was 11.6/1,000,000 person-years in 1990 and it decreased to 8.2/1,000,000 by 2017. Correspondingly, the incidence in men was 7.1/1,000,000 in 1990 and decreased to 5.1/1,000,000 by 2017. Some decline in incidence over time was found in all age groups below 80 years, but the decline (2.3-3.1% per year) was statistically significant only in age groups 40-49, 50-59, and 60-69 years. In the oldest age group (80+ years), the incidence of VS increased by 16% per year. For 2018-2022, the ASR was 7.6/1,000,000 for both sexes combined, with a decline by -1.7% (95% CI: -2.3%, -1.2%) annually for the entire period 1990-2022. In contrast to the increasing incidence reported in some studies, we found a decreasing trend in VS incidence for both sexes in Finland.

Registration, incidence patterns, and survival trends of central nervous system tumors among children in Germany 1980-2019: An analysis of 40years based on data from the German Childhood Cancer Registry.

Tumors of the central nervous system (CNS) are the second most common type of pediatric cancer in Germany. We aimed to describe registration practice, incidence, and survival patterns for childhood CNS tumors in Germany for the past 40years. Including all CNS tumor cases in children diagnosed at ages 0-14years registered at the German Childhood Cancer Registry (GCCR) in 1980-2019 (for survival analysis 1980-2016), we calculated age-specific and age-standardized incidence rates (ASIR) over time, average annual percentage changes (AAPC), and 1- and 5-year overall survival. While we observed a pronounced increase in ASIR after the establishment of the GCCR during the 1980s, ASIR for all pediatric CNS tumors combined continued to increase markedly from 28.6 per million in 1990-1999 to 43.3 in 2010-2019 (AAPC=2.7% in 1991-2010, AAPC=0.3% in 2010-2019). The 5-year overall survival from CNS tumors improved from 63% in the 1980s, 70% in the 1990s to 79% in 2010-2016. These improvements have occurred across all age groups. Children diagnosed with ependymomas and choroid plexus tumors experienced the strongest increase (from 54% to 81%). Observed increases in incidence rates for pediatric CNS tumors are likely only partially caused by actual increasing case numbers. The majority is a function of improved registration and, to a minor extent, improvements in diagnostics. Survival from pediatric CNS tumors has, by and large, improved consistently, leading to a growing population of childhood cancer survivors with diverse health biographies and risk of lifelong adverse impact on health and wellbeing.

Using Delphi method to address factors contributing to aggressive behaviour in mental health settings.

WHAT IS KNOWN ABOUT THE SUBJECT?: Nurses' perspectives and consensus on the possible key factors contributing to aggression at inpatient units can be summarized into patients' related factors, staff related factors and environment related factors. Results of the possible factors contributing to aggression at inpatient units reflect the complicated nature of this problem. WHAT THE PAPER ADDS TO EXISTING KNOWLEDGE: Perspectives of nurses as frontline mental health professionals on factors contributing to aggression as one of the psychiatric emergencies were considered through an iterative process. This approach gave nurses an opportunity to revisit their own views in each round to provide an in-depth reflection in the light of the contribution of others. WHAT ARE THE IMPLICATIONS FOR MENTAL HEALTH NURSING PRACTICE?: Nursing curricula should focus on nurses' communication skills and emotion regulation training. An open dialogue between nurses and people with mental health issues should be initiated to discuss the possible key factors contributing to aggressive behaviour at inpatient units from both standpoints. Mental health nurses' turnover at inpatient settings could be targeted through the design and implementation of aggression prevention protocols ABSTRACT: Introduction Aggression at inpatient units is a universal problem leading to hazardous outcomes. Aim To generate group consensus about factors contributing to aggressive behaviour among patients with mental health issues at inpatient units. Methods Nurses working at inpatient psychiatric departments were approached, and purposive sampling was employed to implement Delphi technique. A total of three Delphi rounds were conducted online. The average percent of majority opinions method was followed to measure consensus in which questions with a cut-off rate below 69.7% were included in the next round. Results Twenty-one nurse experts with different skills participated in this study. Consensus increased among nurse experts across rounds for the following items: Patients' misinterpretation of the attitude of the healthcare providers, severity of mental health issues, attitude and communication style of the healthcare providers, nurses limited emotional regulation capacity and the inadequate staff-patient ratio in psychiatric wards. Discussion The complicated nature of aggressive behaviour displayed by people with mental health issues is reflected on the results of the current study; patients' related factors, staff related factors and environment related factors constitute interacting facets for this issue. Implications for Mental Health Nurses Nurse scientists could use insights derived from this study to design studies aiming at assessment and management of aggression at inpatient units guided by implementation science frameworks. Additionally, open dialogues between nurses and people with mental health issues could be initiated about factors contributing to aggression at inpatient units. Mental health nursing training should focus on nurses' communication and emotion regulation skills.

How have US colorectal cancer mortality trends changed in the past 20 years?

In the last two decades, colorectal cancer (CRC) mortality has been decreasing in the United States. However, the mortality trends for the different subtypes of CRC, including different sides of colon, rectosigmoid, and rectal cancer remain unclear. We analyzed the mortality trends of different subtypes of CRC based on Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research data from 1999 to 2020. We calculated age-adjusted mortality rates (AAMR) per 100,000 individuals and examined the trends over time by estimating the average annual percent change (AAPC) using the Joinpoint Regression Program. Our study shows that the overall CRC rates decreased significantly from 26.42 to 15.98 per 100,000 individuals, with an AAPC of -2.41. However, the AAMR of rectosigmoid cancer increased significantly from 0.82 to 1.08 per 100,000 individuals, with the AAPC of +1.10. Men and Black individuals had the highest AAMRs respectively (23.90 vs. 26.93 per 100,000 individuals). The overall AAMR of CRC decreased for those aged ≥50 years but increased significantly from 1.02 to 1.58 per 100,000 individuals for those aged 15-49 years, with an AAPC of +0.75. Rural populations had a higher AAMR than the urban populations (22.40 vs. 19.60 per 100,000 individuals). Although overall CRC mortality declined, rising trends in young-onset CRC and rectosigmoid cancer warrant attention. Disparities persist in terms of sex, race, and geographic region, and urbanization level, emphasizing the need for targeted public health measures.

Modeling liquid rate through wellhead chokes using machine learning techniques

Precise measurement and prediction of the fluid flow rates in production wells are crucial for anticipating the production volume and hydrocarbon recovery and creating a steady and controllable flow regime in such wells. This study suggests two approaches to predict the flow rate through wellhead chokes. The first is a data-driven approach using different methods, namely: Adaptive boosting support vector regression (Adaboost-SVR), multivariate adaptive regression spline (MARS), radial basis function (RBF), and multilayer perceptron (MLP) with three algorithms: Levenberg–Marquardt (LM), bayesian-regularization (BR), and scaled conjugate gradient (SCG). The second is a developed correlation that depends on wellhead pressure (Pwh), gas-to-liquid ratio (GLR), and choke size (Dc). A dataset of 565 data points is available for model development. The performance of the two suggested approaches is compared with earlier correlations. Results revealed that the proposed models outperform the existing ones, with the Adaboost-SVR model showing the best performance with an average absolute percent relative error (AAPRE) of 5.15% and a correlation coefficient of 0.9784. Additionally, the results indicated that the developed correlation resulted in better predictions compared to the earlier ones. Furthermore, a sensitivity analysis of the input variable was also investigated in this study and revealed that the choke size variable had the most significant effect, while the Pwh and GLR showed a slight effect on the liquid rate. Eventually, the leverage approach showed that only 2.1% of the data points were in the suspicious range.

Generalized Analytical Well-Test Solutions for Vertically Fractured Wells in Commingled Reservoirs

Abstract Layered zones with vertical fracture are often found in analyzing well-test data of deep/ultra-deep reservoirs and tight reservoirs. Analyzing and modeling the well-test data in a computation-accurate and easy-program manner have been a challenge for these problems due to the lack of suitable solutions. This work thus presents the generalized analytical well-test solutions for vertically fractured wells in infinite and bounded commingled reservoirs with computation accuracy and functional simplicity. These solutions are derived based on the early-time approximate solution of the infinite/finite-conductivity fracture model, Laplace and Fourier cosine transformation, pressure superposition principle, and Duhamel principle. Subsequently, model validation is carried out by comparing the pressure and derivative results with those of commercial saphir software. The results show that the average absolute percent deviation between the presented analytical solutions and saphir for three kinds of outer boundaries is ∼2% for pressure results and ∼4% for pressure derivative results. Finally, a field case in Xinjiang oilfield is interpreted, indicating that the proposed analytical well-test solutions are feasible to interpret the parameters of commingled reservoirs.

Surface runoff in six years of rehabilitation of two areas after bauxite mining in Southeastern Brazil

The analysis of surface runoff pre-mining and during six years of rehabilitation with Eucalyptus plantation, post-mining, in bauxite mining areas was the central objective of this work. Surface runoff was monitored from January to May before mining and in the same months from the first to the sixth year of rehabilitation, being collected in seven plots in two bauxite mining areas in southeastern Brazil. The factors that interfere with runoff were characterized in all periods, statistically compared by the Wilcoxon test and submitted to principal component analysis (PCA). The total surface runoff in the five months before mining was 1.74 to 14.06 times greater than the runoff in the same months in the six years of rehabilitation. The average percentage runoff was <1% of the precipitation in all rehabilitation periods, in contrast before mining 1.3% of the precipitation of 556 mm became surface runoff. The highest slopes of the regression were for the first year of rehabilitation and for the pre-mining period, showing a greater influence of precipitation on the generation of surface runoff. Soil, litter and vegetation characteristics were the most explanatory factors in the six-year PCA. Specific factors must be viewed with caution on micro scale in each year of rehabilitation of surface bauxite mines, due to soil heterogeneity and consequent vegetation, seeking to minimize the negative effects on surface runoff. Gap in knowledge about surface runoff percentages in six years of rehabilitation in Brazil and tropical areas was filled. Mine managers can more clearly define the priority factors in strategies to mitigate the effects of mining on the environment from the first to the sixth year of rehabilitation in surface mined areas.

Temporal trends in prevalence and disability of chronic kidney disease caused by specific etiologies: an analysis of the Global Burden of Disease Study 2019.

The prevalence of disability in CKD is high. In this context the aim of the present study wasto assess the temporal trends of prevalence and disability progression for chronic kidney disease (CKD) caused by specific etiologies. Using data from the Global Burden of Diseases Study (GBD) 2019, we examined the age-standardized rates of CKD prevalence and disability-adjusted life-years for different etiologies, including Type 1/2 diabetes mellitus (T1DM/T2DM), glomerulonephritis, and hypertension. We also calculated the average annual percentage changes to assess trends. Additionally, we utilized the joinpoint regression model to identify significant shifts over time. From 1990 to 2019, the global prevalence of CKD due to various etiologies exhibited an overall increasing trend, albeit with fluctuations. Notably, CKD due to T1DM, glomerulonephritis, and hypertension consistently demonstrated a significant upward trend across all continents, while the prevalence of CKD due to T2DM varied across continents. In terms of disability-adjusted life-years, CKD due to T2DM and hypertension exhibited a significant rising trend over the past 30 years. However, changes in age standardized disability-adjusted life-years for CKD due to different etiologies were not consistent across continents, with an upward trend observed in The Americasand a contrasting trend in Asia. Furthermore, both age-standardized prevalence rate and age standardized disability-adjusted life-year trends for CKD varied significantly across 204 countries and territories. Additionally, a negative association was observed between the Socio-demographic Index and the disability progression of CKD. The prevalence and disability burden of CKD caused by specific etiologies show substantial heterogeneity worldwide, highlighting significant disparities in the distribution of CKD. It is crucial to implement geographic and personalized strategies in different regions to alleviate the burden of CKD effectively.

Fabrication of date palm kernel biochar-sulfur (DPKB-S) for super adsorption of methylene blue dye from water

A novel form of biochar was created by dehydration of Date palm kernel with 85% sulfuric acid. It was examined how the newly produced biochar (DPKB-S) affected the aqueous solution's capacity to extract Methylene Blue (MB) dye. The prepared DPKB-S was categorized by BET, BJH, FT-IR, SEM, EDX, DSC, and TGA analyses. The ideal pH for the MB dye adsorption by DPKB-S is 8. With 0.75 g L−1 of DPKB-S and an initial concentration of 50 ppm MB dye, Date Palm Kernel Biochar-Sulfur (DPKB-S) had the highest removal percentage of 100%. The Langmuir and Freundlich isotherm models were used to investigate the collected data. Freundlich model is the model that best covers MB dye adsorption in DPKB-S at low concentrations (0.75–1.25 g L−1) and the Langmuir model at high concentrations (1.5–1.75 g L−1). The Langmuir model maximum adsorption capacity (Qm) of the DPKB-S was 1512.30 mg g−1. Furthermore, a variety of error function models were applied to investigate the isotherm models derived data, including Marquardt’s percent standard deviation (MPSD), the sum of absolute errors (EABS), the sum of the errors squared (ERRSQ), root mean square errors (RMS), Chi-square error (X2), the average relative error (ARE), average percent errors (APE), and hybrid error function (HYBRID). Kinetic data were calculated by intraparticle diffusion (IPD), pseudo-second-order (PSO), pseudo-first-order (PFO), and film diffusion (FD) models. A PSO rate model with a strong correlation (R2 = 1.00) largely regulated the adsorption rate. The removal mechanism of MB dye by DPKB-S is based on the principle that these positively charged dyes are attracted by electrostatic attraction forces due to the growth in the number of negatively charged regions at basic pH value. According to the results, DPKB-S shows promise as an affordable and competent adsorbent for the adsorption of MB dye. It can be used frequently without experiencing a discernible decrease in adsorption efficiency.

Knowledge of Healthcare Workers Regarding Road Traffic Child Safety in South Bačka District, Serbia.

Healthcare workers (HCW) can have an important role in educating parents about child road safety, but research on the topic shows that they usually do not have adequate knowledge. Thus, the aim of our study was to analyze their knowledge in the field of child road safety. The cross-sectional study was conducted among HCW from South Bačka district, Serbia, using a specially created questionnaire for assessing knowledge on road traffic injuries in children. The research involved the participation of 317 healthcare workers (86 physicians and 231 nurses). Healthcare workers from primary healthcare made up almost 70% of all respondents, followed by those from tertiary (21.8%) and secondary (11.3%) level institutions. The average percentage of correct answers on the knowledge test was 74.3% (mean=22.3, SD=4.0). Out of all respondents, HCWs employed in the paediatrics department had a significantly higher percentage of correct answers at 77.7% (mean=23.3, SD=3.4) compared to other health workers at 73% (mean=21.9, SD=4.1) (p=0.002). Association analysis demonstrated that HCW employed at paediatric departments on average scored 1.37 (95% CI: 0.40-2.33, p=0.006) points higher in comparison with other HCW. This research demonstrated an unsatisfactory level of knowledge on child road safety by HCW, and the variability across different question domains, which underlines the need for continuous educations in order to improve their knowledge. Our results may serve in planning additional public health measures and can provide a reference for future studies.

Abstract P480: Digesting Detention: Investigating Eating Patterns in Jails

Background: Over 12 million people cycle through jails every year in the US. People incarcerated experience significant health inequities compared to the general population, including higher rates of hypertension, diabetes, and cardiovascular disease. Despite widespread acceptance of the association between diet and cardiovascular-related outcomes, research documenting dietary intake and nutritional status of individuals incarcerated in jail is limited. Food intake is notoriously difficult to measure, and current measurement tools are not designed for the jail setting. Objectives and Hypotheses: The objectives of this study were to 1) develop a food intake questionnaire for incarcerated adults; 2) document participants’ perceived accuracy of the instrument and 3) compare calorie, macronutrient, and micronutrient intake of people incarcerated in jail to the Acceptable Macronutrient Distribution Range (AMDR) and the 2020-2025 Dietary Guidelines for Americans (DGA). We hypothesized that participants would consume more sodium, added sugar, and saturated fat while incarcerated compared to the DGA and macronutrient consumption patterns of people incarcerated in jail would not meet the AMDR. Methods: Cycle menus were obtained from the jail administration to design a questionnaire that would allow study participants to accurately document the consumption of foods provided by the jail and purchased through commissary each day. Sixty-five (65) incarcerated adults (24 women and 41 men) were recruited from a northern Arizona county jail to complete the 4-day cross-sectional food intake questionnaire. Participants were asked to fill out the questionnaires in real time. Following the study period, questionnaires were collected, and participants provided feedback on the appropriateness and feasibility of the questionnaire via a group listening session. Daily total and mean calorie, macro- and micronutrient intake were calculated using the ASA24 and compared to the AMDR and the DGA. Results: Of 65 people recruited, 64 completed the questionnaire. Participants reported enjoying reflecting on their diets but indicated that institutional menu modifications during the study period led to confusion as the food items listed did not always match what was served. Average percent saturated fat of total calories (11.7%, 95% CI: 10.9, 12.4) and sodium (3723 mg, 95% CI: 3048, 4399) exceeded DGA recommendations. Macronutrient consumption was within recommended ranges. Conclusions: The results of this study can inform efforts to improve the food intake tracking tool which can be used in future research assessing nutritional status in jails and prisons, as well as other controlled food environments. These results will also provide the first observational evidence of nutritional status in jail settings, informing future institutional policy change and interventions.

Global, regional, and national burden of non-communicable diseases attributable to occupational asbestos exposure 1990–2019 and prediction to 2035: worsening or improving?

Understanding the burden associated with occupational asbestos exposure on a global and regional scale is necessary to implement coordinated prevention and control strategies. By the GBD Study 2019, we conducted a comprehensive assessment of the non-communicable diseases burden attributable to occupational asbestos exposure. In 2019, 239,330 deaths and 4,189,000 disability-adjusted life years (DALYs) worldwide due to occupational asbestos exposure occurred. 1990–2019, deaths and DALYs attributed to occupational asbestos exposure increased by 65.65% and 43.66%, respectively. Age-standardized mortality rate (ASMR) and age-standardized DALYs rate (ASDR) decreased, with the most rapid declines in high Socio-Demographic Index (SDI) regions, with average annual percent change (AAPC) of − 1.05(95%CI: −1.2, −0.89) and −1.53(95%CI: −1.71, −1.36), respectively. Lung cancer, mesothelioma and ovarian cancer were the top three contributors to the increase in deaths and DALYs, accounting for more than 96%. AAPCs of ASMR and ASDR were positively associated with SDI. Global deaths from occupational asbestos exposure were predicted to increase and ASMR to decrease by 2035, mostly in males. Due consideration should be given to the susceptibility of the elderly, the lag of asbestos onset, and the regional differences, and constantly improve the prevention and control measures of occupational asbestos exposure and related diseases.

Global, regional, and national temporal trends of diet-related ischemic stroke mortality and disability from 1990 to 2019.

Stroke is the second leading cause of death and the third leading cause of disability in the general population worldwide. However, the changing trend of ischemic stroke burden attributable to various dietary risk factors has not been fully revealed and may contribute to a better understanding of stroke epidemiology. Our article aimed to evaluate the temporal trend of diet-related ischemic stroke burden to inform future research and policy-making. This analysis was based on the data from the Global Burden of Disease (GBD) Study 2019 (spanning years 1990 to 2019), and we used the joinpoint regression to model temporal trends in diet-related ischemic stroke burden across countries and regions of the world during the study period. Six specific dietary factors known to influence stroke risk, including sodium, red meat, fiber, vegetables, whole grains, and fruits, were evaluated in the GBD study to determine their individual and joint impact on ischemic stroke. The changing trend was primarily measured by the average annual percent change (AAPC). Age-standardized rates (ASRs) of mortality and years lived with disability (YLD) per 100,000 population were used to evaluate disease burden. Finally, the socioeconomic background, which was quantified as sociodemographic index (SDI), and its association with diet-related ischemic stroke burden were also explored with the Pearson correlation coefficient. During the study period, the ischemic stroke ASR of mortality attributable to overall dietary risk decreased by an average of 1.6% per year, while the ASR of YLD decreased by an average of 0.2% per year. High sodium diet was still a key driver of diet-related ischemic stroke, accounting for 8.4% and 11.0% of deaths and disabilities, respectively, in 2019. In addition, we found a negative association between temporal evolution of stroke burden and socioeconomic background (r = -0.6603 for mortality and r = -0.4224 for disability, P < 0.001), which suggested that the developing countries with weak social and economic foundation faced greater challenges from the ongoing burden of diet-related strokes compared with developed countries. Our study found declining trends and revealed the current status of diet-related ischemic stroke mortality and disability. Interdisciplinary countermeasures involving the development of effective food policies, evidence-based guidelines, and public education are needed in the future to combat this global epidemic. The data used for analysis were open-access and can be obtained from https://vizhub.healthdata.org/gbd-results/.