Abstract
This study investigates the analysis of the combination of Valsartan and Amlodipine besylate using the Infrared Fourier Transform and its quantitative calculations by chemometrics based on partial least squares with several variables. A calibration model has been formulated, and absorbance besylate measurements at wave numbers of 1634-1566 cm-1 for valsartan and 1127-1059 cm-1 for amlodipine every 2.0 cm-1. Then simultaneously determine valsartan and amlodipine combined in the tablet preparation. The Infrared Fourier Transform method used for Amlodipine besylate and Valsartan with calibration are y = 13.1317 X -0.0595 and y = 129,731 X - 0.026. The validation parameters is 0.9995, and 0.9999 for R2 values, RMSCEV is 0.02427 and 0.003189, and PRESS is 0.02121 and 0.0003662. Prediction ability was still acceptable and good for determination. The levels result were (101.52±2.74)% and (98.47±5.71)%, and valid with Relative Standard Deviation (RSD) respectively 2%, and average recovery percent obtained in range of 98-102%. The method identified provided guaranteed compliance with USP 43-NF 38 (2020).
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