Simultaneous Spectrophotometric Estimation of Valsartan and Amlodipine Besylate by Dual Wavelength Method in Tablet Dosage form

Abstract

A simple and rapid spectrophotometric dual wavelength method has been developed for simultaneous estimation of amlodipine besylate and valsartan in tablet dosage form. Two wavelengths selected were 227 and 244nm, for estimation of valsartan and 360 nm for amlodipine besylate using methanol as a solvent. Both the drugs obeyed Beer-Lambert's law over the concentration range 5-100μg/ml and 5-50μg/ ml for valsartan and amlodipine besylate. The r 2 for valsartan and amlodipine besylate were 0.9982 and 0.9973 with mean percent recovery of 100.23 and 99.66 respectively. The Relative standard deviations for validation parameters were found to be less then the 5%.