The aim of the work is to highlight the results of a field experiment on the effectiveness of the preparations "Pop up Plants Humate Potassium" and "Regoplant" in the cultivation of winter wheat. Methods. The field experiment was conducted in 2020/2021 on the lands of L. Pogorilyy UkrNDIPVT (Kyiv agro-soil district of the Right-Bank Forest-Steppe). Experience factors: factor A – tillage system (A1 – traditional, A2 – conservation, A3 – mulching, A4 – mini-till); Factor B – biological products "Potassium Humate + Regoplant" (B1 – control (without the use of preparations), B2 – the use of preparations for seed treatment and crop nutrition. When growing wheat, the traditional technology for the region was used, except for the elements of the experimental scheme. The effectiveness of the preparations was established by determining the biological yield of wheat and its structure compared to the control. Results. The use of humic preparations increased the weight of grain from the ear and the weight of 1000 seeds, which led to an increase in the biological yield of grain and the harvest index. The highest yield of wheat was observed in the traditional tillage system (A1), and the lowest – in the system of mini-till (A4). The largest increase in yield from the use of preparations (40 %) was observed in the version with a conservation tillage system (A2), and the smallest increase (20 %) – in the mulching tillage system version (A3). The experiment factors also influenced the growth of grain quality. In particular, the grain of the control variant contained 12.44 % of crude protein by weight of dry matter (seeds of the third class), and the grain of the experimental variant – 12.84 % of crude protein by weight of dry matter (seeds of the second class). There was also a decrease in the content of nitrogen-free extractive substances and crude ash. Conclusions. The use of "Pop up Plants Humate Potassium" and "Regoplant" had a positive effect on winter wheat yield and grain quality indicators. The average increase in the biological yield of winter wheat under different tillage systems was 30 % of the control. The superiority of the biological yield of winter wheat grain was noted in the variant with ploughing and biological fertilizers. The use of biological fertilizers also helped to improve grain quality indicators. Key words: Winter Wheat, Potassium Humate, Regoplant, Biological Yield, Tillage Systems.