To promote the application of prefabricated walls and autoclaved aerated concrete (AAC) panels in the Metro industry, the seismic resistance investigations on composite enclosure walls (CEWs) of reinforced concrete (RC) frames infilled with AAC panels suitable for the Metro station were performed. Based on the field test arrangement, the corresponding finite element (FE) models were established and verified according to the experimental results. Moreover, the parametric studies, including with or without AAC infill panels, the compressive strength and thickness of the AAC panels, the compressive strength of frame concrete, and the door opening location and width, were further investigated to explore the structural behavior under cycle loads. The results indicate the seismic performance of CEWs can be effectively improved by infilling AAC panels. The increase in the strength and thickness of AAC panels could enhance the load-bearing capacity and ductility of CEWs. The structural stiffness and cumulative energy dissipation of CEWs are increased with the increasing thickness of AAC panels. The increased range of the peak load, ductility, initial stiffness, and cumulative energy dissipation of CEWs would be maintained within 20.5 % when the concrete strength of the RC frame increases from 35 MPa to 45 MPa. With increasing distance between the constructional column and the door opening, the load-bearing capacity of CEWs is significantly decreased, while the ductility is enhanced. The high initial stiffness could be obtained when the door opens near the constructional column. The load-bearing capacity and initial stiffness of CEWs would be decreased with increasing width of the door opening, while the insignificant effect of the changed door opening width on the ductility.