Auditory Temporal Processing Research Articles

HP02: Auditory pathways and epilepsy as part of language development impairment (a preliminary study)

To estimate the impact of child epilepsy on brainstem auditory pathways as part of language development impairment. Introduction: Epilepsy is commonly associated with a language development impairment (LDI). In fact, neurophysiological maturation of cortical neuronal networks are impaired and can result in troubles of the acquisition of cognitive skills that are fundamental to the learning process particularly language. Then language is clearly caused by cortical hyperexcitability of neurons, but involvement of subcortical pathways still unclear. Materials and methods: It’s a retrospective study that collected data of children aged between two and six years-old referred for an LDI exploration. BER and electroencephalogram (EEG) were performed. Children were divided into two groups: 1st group (G1) with a pathological EEG and 2nd group (G2) with a normal EEG. They were matched in age. Children with a non-epileptic encephalopathy were excluded. Latency I, I-III, III-V and I-V intervals were compared between the two groups. t-Student test was used. Results: G1 and G2 included 15 subjects each one. Their mean-age was 3,7±0,9 years-old. Each group included pathological (G1: n=11; G2: n=7) and normal BER. G1 had longer mean I-latency (1,7±0,36 ms) and increased I-III (2,4±0,32 ms), III-V (1,9±0,42 ms) and I-V intervals (4,4±0,54 ms) than G2 (respectively: 1,6±0,25 ms; 2,3±0,15 ms; 1,8±0,19 ms; 4,2±0,23 ms) without a statistical significance. Conclusions: Children with epilepsy showed more altered BER, which could be explained by maturational delay of auditory pathways secondary to epilepsy independently to the impairment of central temporal auditory processing and language skills.

Open-Set Phoneme Recognition Performance With Varied Temporal Cues in Younger and Older Cochlear Implant Users.

The goal of this study was to investigate the effect of age on phoneme recognition performance in which the stimuli varied in the amount of temporal information available in the signal. Chronological age is increasingly recognized as a factor that can limit the amount of benefit an individual can receive from a cochlear implant (CI). Central auditory temporal processing deficits in older listeners may contribute to the performance gap between younger and older CI users on recognition of phonemes varying in temporal cues. Phoneme recognition was measured at three stimulation rates (500, 900, and 1800 pulses per second) and two envelope modulation frequencies (50 Hz and unfiltered) in 20 CI participants ranging in age from 27 to 85 years. Speech stimuli were multiple word pairs differing in temporal contrasts and were presented via direct stimulation of the electrode array using an eight-channel continuous interleaved sampling strategy. Phoneme recognition performance was evaluated at each stimulation rate condition using both envelope modulation frequencies. Duration of deafness was the strongest subject-level predictor of phoneme recognition, with participants with longer durations of deafness having poorer performance overall. Chronological age did not predict performance for any stimulus condition. Additionally, duration of deafness interacted with envelope filtering. Participants with shorter durations of deafness were able to take advantage of higher frequency envelope modulations, while participants with longer durations of deafness were not. Age did not significantly predict phoneme recognition performance. In contrast, longer durations of deafness were associated with a reduced ability to utilize available temporal information within the signal to improve phoneme recognition performance.

Relations between speech‐reception, psychophysical temporal processing, and subcortical electrophysiological measures of auditory function in humans

There is a large amount of variability in performance in masked-speech reception tasks, as well as in psychophysical auditory temporal processing tasks, between listeners with normal or relatively normal low-frequency hearing. In this study we used a cross-sectional dataset collected on 102 listeners (34 young, 34 middle-aged, 34 older) to assess whether variance in these tasks could be explained by variance in subcortical electrophysiological measures of auditory function (auditory brainstem responses and frequency following responses), and whether variance in speech-reception performance could be explained by variance in auditory temporal processing tasks. The potential confounding effect of high-frequency sensitivity was strictly controlled for by using highpass masking noise. Because each high-level construct (masked-speech reception, auditory temporal processing, and subcortical electrophysiological function) was indexed by several variables, we used principal component analyses to reduce the dimensionality of the dataset. Multiple-regression models were then used to assess the associations between the extracted principal components while controlling for a range of possible confounders including age and audiometric thresholds. We found that masked-speech reception was credibly associated with psychophysical auditory temporal processing abilities. No credible associations were found between masked-speech reception and electrophysiological measures of subcortical auditory function, or between psychophysical measures of auditory temporal processing and electrophysiological measures of subcortical auditory function. These results suggest that either the electrophysiological measures of subcortical auditory function used were not sufficiently sensitive to the subcortical neural processes limiting performance in the speech-reception and psychophysical auditory temporal-processing tasks, or that variance in these tasks is largely unrelated to variance in subcortical neural processes in listeners with near-normal hearing.

Detection and Recognition of Asynchronous Auditory/Visual Speech: Effects of Age, Hearing Loss, and Talker Accent.

This investigation examined age-related differences in auditory-visual (AV) integration as reflected on perceptual judgments of temporally misaligned AV English sentences spoken by native English and native Spanish talkers. In the detection task, it was expected that slowed auditory temporal processing of older participants, relative to younger participants, would be manifest as a shift in the range over which participants would judge asynchronous stimuli as synchronous (referred to as the “AV simultaneity window”). The older participants were also expected to exhibit greater declines in speech recognition for asynchronous AV stimuli than younger participants. Talker accent was hypothesized to influence listener performance, with older listeners exhibiting a greater narrowing of the AV simultaneity window and much poorer recognition of asynchronous AV foreign-accented speech compared to younger listeners. Participant groups included younger and older participants with normal hearing and older participants with hearing loss. Stimuli were video recordings of sentences produced by native English and native Spanish talkers. The video recordings were altered in 50 ms steps by delaying either the audio or video onset. Participants performed a detection task in which they judged whether the sentences were synchronous or asynchronous, and performed a recognition task for multiple synchronous and asynchronous conditions. Both the detection and recognition tasks were conducted at the individualized signal-to-noise ratio (SNR) corresponding to approximately 70% correct speech recognition performance for synchronous AV sentences. Older listeners with and without hearing loss generally showed wider AV simultaneity windows than younger listeners, possibly reflecting slowed auditory temporal processing in auditory lead conditions and reduced sensitivity to asynchrony in auditory lag conditions. However, older and younger listeners were affected similarly by misalignment of auditory and visual signal onsets on the speech recognition task. This suggests that older listeners are negatively impacted by temporal misalignments for speech recognition, even when they do not notice that the stimuli are asynchronous. Overall, the findings show that when listener performance is equated for simultaneous AV speech signals, age effects are apparent in detection judgments but not in recognition of asynchronous speech.

Auditory temporal processinzg in children with history of recurrent otitis media with effusion

Objective Several studies report that a history of recurrent otitis media with effusion (OME) can affect the development of the central auditory system and its processing. The aim of the present study was to determine the effects of recurrent OME on the auditory temporal processing using the Gap-In-Noise (GIN) test in children with a positive history in their first five years. Materials and methods In this study, 12 children between 8 and 10 years old were selected. The control group was matched according to the age of study cohort. The GIN test was conducted to assess temporal processing and the approximate threshold and percentage of correct responses were calculated for all participants. Nonparametric test was used to analyze the data. Result Results of the GIN test showed significant differences between the OME and control group (p < .001). Children with recurrent OME performed worse than the control group in this test. No significant difference was observed between the right and left ear performance in both groups (p > .05). Conclusion The study results indicate that, children with recurrent OME suffer from auditory temporal processing to some degree.

Temporal auditory processing in people exposed to musical instrument practice.

To investigate the influence of musical instrument practice on temporal auditory abilities and on the results of cortical potentials related to auditory events (P300) in a group of young musicians compared to individuals without experience in musical practice. This is a prospective cross-sectional observational study. In total, 34 individuals between 18 and 30 years old, of both sexes, took part and were divided in two groups: Group I (GI), composed of musicians (n=16), and Group II (GII), composed of non-musicians (n=18). All participants underwent behavioral evaluation of temporal auditory processing, composed of Duration Pattern Sequence Test (DPS), Pitch Pattern Sequence Test (PPS), Random Gap Detection Test (RGDT) and electrophysiological evaluation - Long Latency Auditory Evoked Potential - P300. GI also answered a specific questionnaire to characterize musical practice. We observed statistically significant differences with superior performance of GI compared with GII in all behavioral tests (p<0.001*). The groups' performance was similar regarding the latency and amplitude parameters analyzed from LLAEP-300 data (p>0.05). The findings show a positive influence of musical practice toward the improvement of auditory abilities of temporal ordering and resolution. All participants presented adequate cortical functioning of the central auditory nervous system, without significant differences between musicians and non-musicians when considering P300 amplitude and latency.

Processamento auditivo temporal e os traços distintivos de crianças com transtorno fonológico

ABSTRACT Purpose: to assess whether there is a relationship between temporal auditory processing skills and altered distinctive features in cases of phonological disorder. Methods: 18 children aged between 6 and 8 years, diagnosed with phonological disorders participated in the research. All children underwent speech-language screening, phonological assessment and the assessment of temporal processing skills through the GIN - Gap in Noise Test, TPF - Frequency Pattern Test and TPD - Duration Pattern Test. The numbers of altered phonemes and distinctive features and the level at which they were in the Implicational Model of Features Complexity were compared with those of the GIN, TPF and TPD tests. The significance level adopted for all statistical tests was 5% (p&lt;0.05). Results: in no comparison and correlation was there statistical significance, but the subjects evaluated showed low performance in temporal auditory processing tasks, according to normative testing standards. Conclusion: in the general analysis, there was no relationship between temporal auditory skills and distinctive traits in the population assessed, even though they had difficulties in temporal auditory processing tasks.

Temporal auditory processing and the distinctive features of children with phonological disorder

RESUMO Objetivo: verificar se existe relação entre as habilidades de processamento auditivo temporal e os traços distintivos alterados nos casos de transtorno fonológico. Métodos: participaram da pesquisa 18 crianças com idades entre 6:0 e 8:0 anos, com diagnóstico de transtorno fonológico. Todas as crianças passaram por triagem fonoaudiológica, avaliação fonológica da criança e pela avaliação das habilidades de processamento temporal por meio dos testes GIN - Gap in Noise Test, TPF - Teste Padrão de Frequência e TPD - Teste Padrão de Duração. Foram comparados os números de fonemas e traços distintivos alterados, o nível em que se encontravam no Modelo Implicacional de Complexidade de Traços com os resultados dos testes GIN, TPF e TPD. O nível de significância adotado para todos os testes estatísticos foi de 5% (p&lt;0,05). Resultados: em nenhuma comparação ou correlação houve significância estatística, porém os sujeitos avaliados apresentaram baixo desempenho nas tarefas de processamento auditivo temporal de acordo com os padrões normativos dos testes. Conclusão: na análise geral, não houve a relação entre as habilidades auditivas temporais e os traços distintivos na população avaliada, muito embora tenham apresentado dificuldades nas tarefas de processamento temporal.

Processamento auditivo temporal em indivíduos expostos à prática musical instrumental

ABSTRACT Purpose To investigate the influence of musical instrument practice on temporal auditory abilities and on the results of cortical potentials related to auditory events (P300) in a group of young musicians compared to individuals without experience in musical practice. Methods This is a prospective cross-sectional observational study. In total, 34 individuals between 18 and 30 years old, of both sexes, took part and were divided in two groups: Group I (GI), composed of musicians (n=16), and Group II (GII), composed of non-musicians (n=18). All participants underwent behavioral evaluation of temporal auditory processing, composed of Duration Pattern Sequence Test (DPS), Pitch Pattern Sequence Test (PPS), Random Gap Detection Test (RGDT) and electrophysiological evaluation – Long Latency Auditory Evoked Potential – P300. GI also answered a specific questionnaire to characterize musical practice. Results We observed statistically significant differences with superior performance of GI compared with GII in all behavioral tests (p&lt;0.001*). The groups’ performance was similar regarding the latency and amplitude parameters analyzed from LLAEP-300 data (p&gt;0.05). Conclusion The findings show a positive influence of musical practice toward the improvement of auditory abilities of temporal ordering and resolution. All participants presented adequate cortical functioning of the central auditory nervous system, without significant differences between musicians and non-musicians when considering P300 amplitude and latency.

Ahead of maturation: Enhanced speech envelope training boosts rise time discrimination in pre-readers at cognitive risk for dyslexia.

Dyslexia has frequently been related to atypical auditory temporal processing and speech perception. Results of studies emphasizing speech onset cues and reinforcing the temporal structure of the speech envelope, that is, envelope enhancement (EE), demonstrated reduced speech perception deficits in individuals with dyslexia. The use of this strategy as auditory intervention might thus reduce some of the deficits related to dyslexia. Importantly, reading-skill interventions are most effective when they are provided during kindergarten and first grade. Hence, we provided a tablet-based 12-week auditory and phonics-based intervention to pre-readers at cognitive risk for dyslexia and investigated the effect on auditory temporal processing with a rise time discrimination (RTD) task. Ninety-one pre-readers at cognitive risk for dyslexia (aged 5-6) were assigned to two groups receiving a phonics-based intervention and playing a story listening game either with (n=31) or without (n=31) EE or a third group playing control games and listening to non-enhanced stories (n=29). RTD was measured directly before, directly after and 1 year after the intervention. While the groups listening to non-enhanced stories mainly improved after the intervention during first grade, the group listening to enhanced stories improved during the intervention in kindergarten and subsequently remained stable during first grade. Hence, an EE intervention improves auditory processing skills important for the development of phonological skills. This occurred before the onset of reading instruction, preceding the maturational improvement of these skills, hence potentially giving at risk children a head start when learning to read. A video abstract of this article can be viewed at https://www.youtube.com/watch?v=e0BfT4dGXNA.

Temporal acuity is preserved in the auditory midbrain of aged mice

Impaired temporal resolution of the central auditory system has long been suggested to contribute to speech understanding deficits in the elderly. However, it has been difficult to differentiate between direct age-related central deficits and indirect effects of confounding peripheral age-related hearing loss on temporal resolution. To differentiate this, we measured temporal acuity in the inferior colliculus (IC) of aged CBA/J and C57BL/6 mice, as a model of aging with and without concomitant hearing loss. We used two common measures of auditory temporal processing: gap detection as a measure of temporal fine structure and amplitude-modulated noise as a measure of envelope sensitivity. Importantly, auditory temporal acuity remained precise in the IC of old CBA/J mice when no or only minimal age-related hearing loss was present. In contrast, temporal acuity was only indirectly reduced by the presence of age-related hearing loss in aged C57BL/6 mice, not by affecting the brainstem precision, but by affecting the signal-to-noise ratio of the neuronal activity in the IC. This demonstrates that indirect effects of age-related peripheral hearing loss likely remain an important factor for temporal processing in aging in comparison to 'pure' central auditory decline itself. It also draws attention to the issue that the threshold difference between ‘nearly normal’ or ‘clinically normal’ hearing aging subjects in comparison to normal hearing young subjects still can have indirect effects on central auditory neural representations of temporal processing.

Aging and auditory temporal ordering

Abstract Background The aging process is characterized by a gradual impairment of several capacities, such as hearing, memory and communication, which implies changes at various levels and, consequently, changes in both hearing and auditory skills, of which the auditory temporal ordering is an example. Methods The sample consisted of 23 elderly individuals, aged between 70 and 96 years (average of 83.09 years) and with mild to severe type I sensorineural hearing loss. For the collection of information, the pure tone audiogram, the frequency and duration pattern tests, the verbal and non-verbal sequential memory tests were used. Results The results revealed that between age and the auditory temporal order tests there was a negative correlation (except in the duration pattern test in the left ear) and between the auditory threshold and the auditory temporal order tests there was negative correlation (except in the duration pattern test in the right ear). Conclusions It is concluded that in this sample the ability of auditory temporal ordering was influenced by aging and hearing loss, which shows that as the age of the elderly progresses and the degree of hearing loss increases the difficulties in temporal auditory processing become larger. This leads us to consider that these elderly have several difficulties in temporal auditory processing and that an intervention as auditory training may be advantageous for the elderly, as it could improve their central auditory processing and, consequently, their hearing, memory and quality of life.

Evidence for a general impairment of auditory and visual temporal order judgment in children with reading disabilities

Objectives: This study examined visual and auditory processing of children with reading disabilities (RD) to determine whether they show an impaired ability to judge a reading-related process such as temporal order of events and clarify whether or not this deficit is linked to rapid processing deficit. Method: The performance of 16 children with RD was compared with the performance of children in two control groups – one for chronological age (CA) and one for the same reading level –, doing visual and auditory temporal order tasks, both with linguistic and non-linguistic stimuli with inter-stimuli-intervals of 50, 150, or 300 ms. Results: The RD group performance was lower than the performance of the CA group in tasks requiring auditory temporal order processing for linguistic and non-linguistic stimuli. Regarding visual tasks, the RD group performed worse than both control groups in processing non-linguistic stimuli. In general, performance in every group decreased with decreasing inter-stimulus-interval (ISIs), suggesting that children with RD do not have impairments in the speed of perceptual processing. Conclusions: The perceptual problems of children with RD are better explained by temporal order processing problems than by difficulties in rapid processing. Inclusion of temporal order processing tasks in the evaluation of children with RD is recommended.

Aging Effects on Cortical Responses to Tones and Speech in Adult Cochlear-Implant Users.

Age-related declines in auditory temporal processing contribute to speech understanding difficulties of older adults. These temporal processing deficits have been established primarily among acoustic-hearing listeners, but the peripheral and central contributions are difficult to separate. This study recorded cortical auditory evoked potentials from younger to middle-aged (< 65years) and older (≥ 65years) cochlear-implant (CI) listeners to assess age-related changes in temporal processing, where cochlear processing is bypassed in this population. Aging effects were compared to age-matched normal-hearing (NH) listeners. Advancing age was associated with prolonged P2 latencies in both CI and NH listeners in response to a 1000-Hz tone or a syllable /da/, and with prolonged N1 latencies in CI listeners in response to the syllable. Advancing age was associated with larger N1 amplitudes in NH listeners. These age-related changes in latency and amplitude were independent of stimulus presentation rate. Further, CI listeners exhibited prolonged N1 and P2 latencies and smaller P2 amplitudes than NH listeners. Thus, aging appears to degrade some aspects of auditory temporal processing when peripheral-cochlear contributions are largely removed, suggesting that changes beyond the cochlea may contribute to age-related temporal processing deficits.

Auditory temporal processing deficits in developmental dyslexia

Auditory temporal processing deficits in developmental dyslexia

Rescuing Auditory Temporal Processing with a Novel Augmented Acoustic Environment in an Animal Model of Congenital Hearing Loss.

Congenital sensorineural hearing loss (SNHL) affects thousands of infants each year and results in significant delays in speech and language development. Previous studies have shown that early exposure to a simple augmented acoustic environment (AAE) can limit the effects of progressive SNHL on hearing sensitivity. However, SNHL is also accompanied by hearing loss that is not assessed on standard audiological examinations, such as reduced temporal processing acuity. To assess whether sound therapy may improve these deficits, a mouse model of congenital SNHL was exposed to simple or temporally complex AAE. The DBA/2J mouse strain develops rapid, base to apex, progressive SNHL beginning at birth and is functionally deaf by six months of age. Hearing sensitivity and auditory brainstem function was measured using otoacoustic emissions, auditory brainstem response (ABR) and extracellular recording from the inferior colliculus (IC) in mice following exposure to 30 d of continuous AAE. Peripheral function and sound sensitivity in auditory midbrain neurons improved following exposure to both types of AAE. However, exposure to a novel, temporally complex AAE more strongly improved a measure of temporal processing acuity, neural gap-in-noise detection in the auditory midbrain. These experiments suggest that targeted sound therapy may be harnessed to improve hearing outcomes for children suffering from congenital SNHL.

Preferred auditory temporal processing regimes and auditory-motor synchronization

Decoding the rich temporal dynamics of complex sounds such as speech is constrained by the underlying neuronal-processing mechanisms. Oscillatory theories suggest the existence of one optimal perceptual performance regime at auditory stimulation rates in the delta to theta range (< 10 Hz), but reduced performance in the alpha range (10–14 Hz) is controversial. Additionally, the widely discussed motor system contribution to timing remains unclear. We measured rate discrimination thresholds between 4 and 15 Hz, and auditory-motor coupling strength was estimated through a behavioral auditory-motor synchronization task. In a Bayesian model comparison, high auditory-motor synchronizers showed a larger range of constant optimal temporal judgments than low synchronizers, with performance decreasing in the alpha range. This evidence for optimal processing in the theta range is consistent with preferred oscillatory regimes in auditory cortex that compartmentalize stimulus encoding and processing. The findings suggest, remarkably, that increased auditory-motor synchronization might extend such an optimal range towards faster rates.

Auditory Temporal Processing in Dancers.

While many studies have examined the auditory abilities of musicians, this study uniquely asks whether dance training, a similar yet understudied type of early-life training, also benefits auditory abilities. We focused this investigation on temporal resolution, given the importance of subtle temporal cues in synchronizing movement. We found that, compared to untrained controls, novice adult dancers who have trained continuously since childhood had enhanced temporal resolution, measured with a gap detection task. In an analysis involving current and former dancers, total years of training was a significant predictor of temporal resolution thresholds. The association between dance experience and improved auditory skills has implications for current theories of experience-dependent auditory plasticity and the design of sound-based educational and rehabilitation activities.

Allophonic perception of VOT contrasts in Spanish children with dyslexia.

IntroductionPrevious studies have evidenced a different mode of speech perception in dyslexia, characterized by the use of allophonic rather than phonemic units. People with dyslexia perceive phonemic features (such as voicing) less accurately than typical readers, but they perceive allophonic features (i.e., language‐independent differences between speech sounds) more accurately.MethodIn this study, we investigated the perception of voicing contrasts in a sample of 204 Spanish children with or without dyslexia. Identification and discrimination data were collected for synthetic sounds varying along three different voice onset time (VOT) continua (ba/pa, de/te, and di/ti). Empirical data will be contrasted with a mathematical model of allophonic perception building up from neural oscillations and auditory temporal processing.ResultsChildren with dyslexia exhibited a general deficit in categorical precision; that is, they discriminated among phonemically contrastive pairs (around 0‐ms VOT) less accurately than did chronological age controls, irrespective of the stimulus continuum. Children with dyslexia also exhibited a higher sensitivity in the discrimination of allophonic features (around ±30‐ms VOT), but only for the stimulus continuum that was based on a nonlexical contrast (ba/pa).ConclusionFitting the neural network model to the data collected for this continuum suggests that allophonic perception is due to a deficit in “subharmonic coupling” between high‐frequency oscillations. Relationships with “temporal sampling framework” theory are discussed.

Enhanced Neural Tracking of the Fundamental Frequency of the Voice.

'F0 tracking' is a novel method that investigates neural processing of the fundamental frequency of the voice (f0) in continuous speech. Using linear modelling, a feature that reflects the f0 of a presented speech stimulus is predicted from neural EEG responses. The correlation between the predicted and the 'actual' f0 feature is a measure for neural response strength. In this study, we aimed to design a new f0 feature that approximates the expected human EEG response to the f0 in order to improve neural tracking results. Two techniques were explored: constructing the feature with a phenomenological model to simulate neural processing in the auditory periphery and low-pass filtering the feature to approximate the effect of more central processing. Analysis of EEG-data evoked by a Flemish story in 34 subjects indicated that both the auditory model and the low-pass filter significantly improved the correlations between the actual and reconstructed feature. The combination of both strategies almost doubled the mean correlation across subjects, from 0.078 to 0.13. Moreover, canonical correlation analysis revealed two distinct processes contributing to the f0 response: one driven by broad range of auditory nerve fibers with center frequency up to 8 kHz and one driven by a more narrow selection of auditory nerve fibers, possibly responding to unresolved harmonics. Optimizing the f0 feature towards the expected neural response, significantly improves f0-tracking correlations. The optimized f0 feature enhances the f0-tracking method, facilitating future research on temporal auditory processing in the human brain.