Auditory Event-related Potentials Research Articles

Auditory and speech function after cochlear implantation in prelingually deaf children with white matter lesions.

To explore how auditory and speech function developed post-cochlear implantation (pCI) in prelingually deaf children with white matter lesions (WML). Patients (41 males, 29 females; mean age at implantation 2y 11mo [SD 7.5mo], range 1y 8mo-5y) were divided into the following groups according to preoperative brain magnetic resonance imaging evaluation: mild WML, moderate WML, severe WML, and control. We assessed auditory and speech performance at baseline, 6months, 12months, and 24months pCI. As well as auditory event-related potentials, topographic maps and electroencephalography source imaging were recorded and analysed at 24months pCI. For children with WML (any level), postoperative auditory or speech performance at 6months was significantly below that of control participants. After stratification, auditory and speech performance was highly related to WML grading. Auditory or speech performance in mild WML or control groups was comparatively better than the moderate WML and severe WML groups. The recovery rate of speech performance fell behind that of the auditory perception. With the increasing severity of WML, N1 amplitude was significantly smaller with a consistent presentation in the topographic map, which was similar in the mild WML and control group. The dominant auditory centre was activated in the control or mild WML groups, but not in the moderate WML and severe WML groups. WML gradually affect auditory and speech development, and electrophysiological performance pCI in prelingually deaf children. Auditory and speech performance in prelingually deaf children with white matter lesions (WML) was significantly worse than those without WML. Postoperative auditory and speech performance in children with WML was highly related to WML grading. Grand N1 amplitude in auditory event-related potentials was negatively related to the severity of WML. Non-dominant areas close to the auditory cortex were potentially activated in severe WML.

Developmental Changes in EEG Phenotypes in a Mouse Model of Fragile X Syndrome

Fragile X Syndrome (FXS) is a leading genetic cause of autism and intellectual disabilities. Sensory-processing deficits are common in humans with FXS and an animal model, the Fmr1 knockout (KO) mouse, manifesting in the auditory system as debilitating hypersensitivity and abnormal electroencephalographic (EEG) and event-related potential (ERP) phenotypes. FXS is a neurodevelopmental disorder, but how EEG/ERP phenotypes change during development is unclear. Therefore, we characterized baseline and stimulus-evoked EEG in auditory and frontal cortex of developing (postnatal day (P) 21 and P30) and adult (P60) wildtype (WT) and Fmr1 KO mice with the FVB genetic background. We found that baseline gamma-band power and N1 amplitude of auditory ERP were increased in frontal cortex of Fmr1 KO mice during development and in adults. Baseline gamma power was increased in auditory cortex at P30. Genotype differences in stimulus-evoked gamma power were present in both cortical regions, but the direction and strength of the changes were age-dependent. These findings suggest that cortical deficits are present during early development and may contribute to sensory-processing deficits in FXS, which in turn may lead to anxiety and delayed language. Developmental changes in EEG measures indicate that observations at a single time-point during development are not reflective of FXS disease progression and highlight the need to identify developmental trajectories and optimal windows for treatment.

Use of event related potential markers in patients with traumatic brain injury

ObjectiveTo investigate whether event related potentials (ERP) could improve diagnosis and management of traumatic brain injury (TBI) patients in an outpatient setting.BackgroundThough important progress has been made in our understanding of how traumatic brain injury (TBI) affects the brain, diagnosis remains suboptimal, especially in the mild stages of the disease. A real time physiologic measure of brain cortical synaptic function such as event related potentials (ERP) can measure the sensory and cognitive deficits that follow TBI even at the subclinical stages of the disease. Even though the potential of ERP as a diagnostic tool for TBI has been known for several years, the impracticality of running ERP tests in clinical environments on real patients has limited widespread clinical application in the past. Recently, advances in electronics and analysis algorithms have made it practical for ERP tests to be administered in outpatient settings on real patients, thus creating an opportunity to evaluate ERP as an index of functional pathophysiology for TBI in clinical environments.Design/methodsThree patients with acute mild TBI were administered an auditory oddball ERP paradigm in conjunction with standard clinical evaluation.ResultsERPs were an informative measure for understanding covert deficits in cognition. Several ERP components revealed selective dysfunction following sport concussion. ERP testing in this case series increased confidence in diagnosis and prognosis for this population of sport-related concussion, thus leading to better patient management. Through this data, we are now equipped with better insight on which TBI patients would benefit most from the addition of ERP testing to the standard clinical workup.ConclusionsAnalysis of ERP data provides valuable information in patients with TBI, especially in mild cases where neuroimaging studies are non-revealing.

Social-emotional processing in nonverbal individuals with Angelman syndrome: evidence from brain responses to known and novel names.

The combination of intellectual, communicative and motor deficits limits the use of standardised behavioural assessments in individuals with Angelman syndrome (AS). The current study aimed to objectively evaluate the extent of social-emotional processing in AS using auditory event-related potentials (ERPs) during passive exposure to spoken stimuli. Auditory ERP responses were recorded in 13 nonverbal individuals with the deletion subtype of AS, age 4-45years, during the name recognition paradigm, in which their own names and names of close others (relative or friend) were presented among novel names. No behavioural responses were required. Contrary to findings in typical children and adults, there was no significant evidence of differential neural response to known vs. novel names in participants with AS. Nevertheless, greater amplitude differences between known and unknown names demonstrated the predicted association with better interpersonal relationships and receptive communication abilities. These findings indicate good tolerability of ERP procedures (85% success rate). The lack of own name differentiation is consistent with increased incidence of the autism-related symptoms in AS. Strong associations between the caregiver reports of adaptive functioning and neural indices of known name recognition support the utility of brain-based measures for objectively evaluating cognitive and affective processes in nonverbal persons with neurodevelopmental disorders.

Feasibility of using auditory event-related potentials to investigate learning and memory in nonverbal individuals with Angelman syndrome

The combination of intellectual, communicative, and motor deficits limit the use of standardized behavioral assessments of cognition in individuals with Angelman syndrome (AS). The current study is the first to objectively evaluate learning and memory in AS using auditory event-related potentials (ERP) during passive exposure to spoken stimuli. Fifteen nonverbal individuals with the deletion subtype of AS (age 4–45 years) completed the auditory incidental memory paradigm. Auditory ERPs were recorded in response to a sequence of unfamiliar nonwords, in which one randomly selected stimulus was repeated multiple times and the rest were presented once. Larger parietal responses within 200–500 ms for the repeated nonword compared to novel distracters were associated with caregiver reports of more adaptive communication skills. These findings demonstrate good tolerability of ERP procedures (94% success rate) and indicate that persons with AS can acquire new information following repeated auditory exposure, even in the absence of explicit memorization instructions. Strong associations between the caregiver reports of adaptive functioning and neural indices of auditory learning and memory support the utility of brain-based measures for objectively evaluating higher-order information processing in nonverbal persons with neurodevelopmental disorders.

Computer-assisted reading intervention for children with sensorineural hearing loss using hearing aids: Effects on auditory event-related potentials and mismatch negativity

ObjectivesThe primary aim was to investigate whether computer-assisted reading intervention somehow can affect event-related potentials (ERP) and mismatch negativity (MMN) in hearing impaired (HI) children with hearing aids (HAs) and normal hearing (NH) children. MethodsThe study included 15 HI children with sensorineural hearing loss (SNHL) using bilateral HAs and 14 NH children as a reference group; all children between the ages of 5 and 8. A multi-feature MMN-paradigm, Optimum-1, with a standard stimulus alternating with 5 different deviants was used. ERPs were recorded pre and post intervention, i.e. one month of repeatedly computer-assisted training (GraphoGame). MMN was calculated from the average ERP of each deviant minus standard. Data were based on samples within a specific time interval, 80–224 ms, and repeated measures ANOVA was used to analyze possible interactions. ResultsThere was a significant difference between groups before training, though, the mean obligatory responses or MMN was not statistically significantly different before versus after training, neither among the NH nor the HI children. Further, the HI children did generally achieve lower levels in GraphoGame compared to the NH children. Altogether, our findings indicate differences between the groups and that training may affect the neurophysiological processing in the brain, gaining the HI children. Both MMN and positive mismatch response (pMMR) were seen among both the HA and NH children, irrespective to deviant type. Individually, changes of the MMN and pMMR after training seem unpredictable. ConclusionThere are statistically significant differences in both the obligatory responses in ERP and the MMNs between the NH and HI groups before the computer-assisted training. Though, these differences disappear after the intervention. This suggests possible training effects regarding the central auditory processing among the HI children.

Auditory sensitivity exhibits sexual dimorphism and seasonal plasticity in music frogs.

Seasonal changes in the structure and function of the vertebrate brain have been described in many species, particularly in seasonal breeders. However, it remains unclear whether sexual dimorphism varies between breeding seasons for specific brain regions. Auditory event-related potential (ERP) changes were evaluated in the Emei music frog (Babina daunchina) to assess sexual dimorphism and seasonal variations in auditory sensitivity. An acoustic playback experiment using an oddball paradigm design was conducted, in which two conspecific call types were used as deviant stimuli with synthesized white noise as standard stimulus. ERP components were analyzed for the telencephalon and mesencephalon of both sexes in the non-reproductive and reproductive states. Results show that auditory sensitivity is modulated by reproductive status, implying that seasonal plasticity is involved in auditory perception. Moreover, the amplitude of the N1 ERP component (mean amplitudes during the interval occurring 30-130ms after stimulus onset) is higher in females for the telencephalon and higher in males for the mesencephalon, regardless of reproductive status and acoustic stimulus type. These results show that auditory ERP responses for specific brain regions exhibit sexual dimorphism in the absence of exogenous sexual stimulation during both the two reproductive states in the music frog.

Reusable Multielectrode Array Technique for Electroencephalography in Awake Freely Moving Mice.

Translational comparison of rodent models of neurological and neuropsychiatric diseases to human electroencephalography (EEG) biomarkers in these conditions will require multisite rodent EEG on the skull surface, rather than local area electrocorticography (ECoG) or multisite local field potential (LFP) recording. We have developed a technique for planar multielectrode array (MEA) implantation on the mouse skull surface, which enables multisite EEG in awake and freely moving mice and reusability of the MEA probes. With this method, we reliably obtain 30-channel low-noise EEG from awake mice. Baseline and stimulus-evoked EEG recordings can be readily obtained and analyzed. For example, we have demonstrated EEG responses to auditory stimuli. Broadband noise elicits reliable 30-channel auditory event-related potentials (ERPs), and chirp stimuli induce phase-locked EEG responses just as in human sound presentation paradigms. This method is unique in achieving chronic implantation of novel MEA technology onto the mouse skull surface for chronic multisite EEG recordings. Furthermore, we demonstrate a reliable method for reusing MEA probes for multiple serial implantations without loss of EEG quality. This skull surface MEA methodology can be used to obtain simultaneous multisite EEG recordings and to test EEG biomarkers in diverse mouse models of human neurological and neuropsychiatric diseases. Reusability of the MEA probes makes it more cost-effective to deploy this system for various studies.

Modulation of auditory sensory memory by chronic clinical pain and acute experimental pain: a mismatch negativity study

Pain, especially chronic pain, can lead to cognitive deficits. Mismatch negativity (MMN) is a change-specific component of the auditory event-related brain potential (ERP) that is thought to provide a unique window into sensory memory processes. The present study was designed to determine how chronic and acute pain affects auditory sensory memory. In experiment 1, MMNs elicited by standard and deviant auditory stimuli at short and long inter-stimulus intervals (ISIs) were compared between trigeminal neuralgia (TN) patients and demographically matched healthy controls (HCs). The TN patients were found to have stronger attenuation of the MMN at longer ISIs than HCs. Correlation analysis revealed a significant positive correlation between the sensory subscale of McGill Pain Questionnaire and MMN amplitude reduction across ISI conditions. In experiment 2, MMNs recorded before, during, and after the cold pressor test were compared in healthy subjects. MMN amplitude was significantly reduced during pain exposure and recovered immediately thereafter. These results suggest that both chronic pain and acute pain can interfere with automatic change detection processes in the brain. This study provides the first evidence that chronic pain patients have a faster auditory memory trace decay than HCs.

Differential effects of hearing impairment and age on electrophysiological and behavioral measures of speech in noise

Understanding speech in background noise is difficult for many listeners with and without hearing impairment (HI). This study investigated the effects of HI on speech discrimination and recognition measures as well as speech-evoked cortical N1-P2 and MMN auditory event-related potentials (AERPs) in background noise. We aimed to determine which AERP components can predict the effects of HI on speech perception in noise across adult listeners with and without HI. The data were collected from 18 participants with hearing thresholds ranging from within normal limits to bilateral moderate-to-severe sensorineural hearing loss. Linear mixed effects models were employed to examine how hearing impairment, age, stimulus type, and SNR listening condition affected neural and behavioral responses and what AERP components were correlated with effects of HI on speech-in-noise perception across participants. Significant effects of age were found on the N1-P2 but not on MMN, and significant effects of HI were observed on the MMN and behavioral measures. The results suggest that neural responses reflecting later cognitive processing of stimulus discrimination may be more susceptible to the effects of HI on the processing of speech in noise than earlier components that signal the sensory encoding of acoustic stimulus features. Objective AERP responses were also potential neural predictors of speech perception in noise across participants with and without HI, which has implications for the use of AERPs as a potential clinical tool for assessing speech perception in noise.

The Relationship between Mismatch Negativity and the COMTVal108/158Met Genotype in Schizophrenia

Mismatch negativity (MMN) is a component of auditory event-related potentials that reflects automatic change detection in the brain, showing qualities of endophenotypes in schizophrenia. MMN deficiency is one of the robust findings in patients, and it reflects both cognitive and functional decline. Catechol-o-methyltransferase (COMT) is a key enzyme involved in regulating dopamine transmission within the prefrontal cortex. A preliminary study suggested that the COMTVal108/158Met genotype (rs4680) is related to cognitive function in schizophrenia. Both the COMTVal108/158Met genotype and MMN are related to cognitive function, but no studies have reported on the relationship between MMN and the COMTVal108/158Met genotype in schizophrenia. This study therefore examined the relationship between COMTVal108/158Met genotype and MMN. The duration of MMN was measured, and the COMTVal108/158Met polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism in 49 Japanese schizophrenia patients (Val/Val, n = 21; Met carriers, n = 28). Amplitude and latency of MMN were compared between Val/Val and Met carriers.

Auditory perception is associated with implicit language learning and receptive language ability in autism spectrum disorder

BackgroundAutism spectrum disorder (ASD) is associated with language impairment as well as atypical auditory sensory processing. The current study investigated associations among auditory perception, implicit language learning and receptive language ability in youth with ASD. MethodsWe measured auditory event related potentials (ERP) during an artificial language statistical learning task in 76 youth with ASD and 27 neurotypical (NT) controls. Participants with ASD had a broad range of cognitive and language abilities. ResultsNT youth showed evidence of implicit learning via attenuated P1 amplitude in the left hemisphere. In contrast, among youth with ASD, implicit learning elicited bilateral attenuation that was increasingly evident with greater receptive language skill. ConclusionsEfficient early auditory perception reflects language learning and is a marker of language ability among youth with ASD. Atypical lateralization of word learning is evident in ASD across a broad range of receptive language abilities.

Habituation to pain and sensitization mechanisms

Deficits in auditory event-related potentials (ERPs), brain responses to stimuli indexing different cognitive processes, have been demonstrated widely in chronic schizophrenia (SZ) patients though much less is known about these responses across the early course of psychosis. The present study examined multiple ERP components in first episode psychosis (FEP) patients longitudinally and investigated the relationships between ERPs, psychosocial functioning, and clinical features over time.N1, P2, P3a, and P3b ERPs were elicited using a three-stimulus (novelty) auditory oddball paradigm. FEP patients included SZ-spectrum and psychotic bipolar disorder (BD) diagnoses. Data were collected from 41 patients at baseline, 20 patients at 12-month follow-up, 14 at 24-month follow-up, and 29 healthy control subjects.N1 and P2 ERPs were intact across the early stages of psychosis. Baseline P2 was significantly larger in BD than SZ patients. Reduced P3a and P3b ERPs were found in patients followed longitudinally and are stable over time. ERPs tracked distinct aspects of symptomology and medication, though specific associations were inconsistent across time. Baseline P3a amplitude predicted later psychosocial functioning. The pattern of correlations between ERP components in patients differed from controls.Baseline P3a ERP, and PANSS general score were significant and independent predictors of later MCAS functioning at 12-month. Overall, individuals with worse functioning and greater symptomology produced smaller amplitudes. Our results highlight the heterogeneity within the FEP population. Correlation patterns among ERPs are similar between patients and controls. P3a and P3b amplitudes appear to link with higher-order cognitive and psychosocial functioning.

The lie detection in the online environment

Deficits in auditory event-related potentials (ERPs), brain responses to stimuli indexing different cognitive processes, have been demonstrated widely in chronic schizophrenia (SZ) patients though much less is known about these responses across the early course of psychosis. The present study examined multiple ERP components in first episode psychosis (FEP) patients longitudinally and investigated the relationships between ERPs, psychosocial functioning, and clinical features over time.N1, P2, P3a, and P3b ERPs were elicited using a three-stimulus (novelty) auditory oddball paradigm. FEP patients included SZ-spectrum and psychotic bipolar disorder (BD) diagnoses. Data were collected from 41 patients at baseline, 20 patients at 12-month follow-up, 14 at 24-month follow-up, and 29 healthy control subjects.N1 and P2 ERPs were intact across the early stages of psychosis. Baseline P2 was significantly larger in BD than SZ patients. Reduced P3a and P3b ERPs were found in patients followed longitudinally and are stable over time. ERPs tracked distinct aspects of symptomology and medication, though specific associations were inconsistent across time. Baseline P3a amplitude predicted later psychosocial functioning. The pattern of correlations between ERP components in patients differed from controls.Baseline P3a ERP, and PANSS general score were significant and independent predictors of later MCAS functioning at 12-month. Overall, individuals with worse functioning and greater symptomology produced smaller amplitudes. Our results highlight the heterogeneity within the FEP population. Correlation patterns among ERPs are similar between patients and controls. P3a and P3b amplitudes appear to link with higher-order cognitive and psychosocial functioning.

The functional state of magnocellular and parvocellular visual pathways and cognitive functions in first-episode of schizophrenia

During vocalization, efference copy/corollary discharge mechanisms suppress the auditory cortical response to self-generated sounds as reflected in the N1 component of the auditory event-related potential (ERP). N1 suppression during talking is reduced in patients with schizophrenia. We hypothesized that these deficits would recover with auditory training that targets the speech processing system.Forty-nine individuals early in the course of a schizophrenia-spectrum illness (ESZ) were randomly assigned to 40 h of Targeted Auditory Training (TAT; n = 23) or Computer Games (CG; n = 26). The N1 ERP component was elicited during production (Talk) and playback (Listen) of vocalization. Effects of Treatment on Global Cognition, N1 suppression (Talk-Listen), N1 during Talking and Listening were assessed. Simple effects of the passage of time were also assessed in the HC after 28 weeks.There was a Treatment × Time interaction revealing that N1 suppression was improved with TAT, but not with CG. TAT, but not CG, also improved Global Cognition. However, TAT and CG groups differed in their pre-treatment N1 suppression, and greater N1-suppression abnormalities were strongly associated with greater improvement in N1 suppression.In this sample of ESZ individuals, targeted auditory training appeared to improve the function of the efference copy/corollary discharge mechanism which tended to deteriorate with computer games. It remains to be determined if baseline N1 suppression abnormalities are necessary for TAT treatment to have a positive effect on efference copy/corollary discharge function or if improvements observed in this study represent a regression to the mean N1 suppression in ESZ.ClinicalTrials.gov NCT00694889. Registered 1 August 2007.

Eyes-Closed Increases the Usability of Brain-Computer Interfaces Based on Auditory Event-Related Potentials.

Recent research has demonstrated how brain-computer interfaces (BCI) based on auditory stimuli can be used for communication and rehabilitation. In these applications, users are commonly instructed to avoid eye movements while keeping their eyes open. This secondary task can lead to exhaustion and subjects may not succeed in suppressing eye movements. In this work, we investigate the option to use a BCI with eyes-closed. Twelve healthy subjects participated in a single electroencephalography (EEG) session where they were listening to a rapid stream of bisyllabic words while alternatively having their eyes open or closed. In addition, we assessed usability aspects for the two conditions with a questionnaire. Our analysis shows that eyes-closed does not reduce the number of eye artifacts and that event-related potential (ERP) responses and classification accuracies are comparable between both conditions. Importantly, we found that subjects expressed a significant general preference toward the eyes-closed condition and were also less tensed in that condition. Furthermore, switching between eyes-closed and eyes-open and vice versa is possible without a severe drop in classification accuracy. These findings suggest that eyes-closed should be considered as a viable alternative in auditory BCIs that might be especially useful for subjects with limited control over their eye movements.

Genetic Association between Alzheimer's Disease Risk Variant of the PICALM Gene and Auditory Event-Related Potentials in Aging.

Aging and genetic predisposition are major risk factors in age-related neurodegenerative disorders. The most common neurodegenerative disorder is Alzheimer's disease (AD). Genome-wide association studies (GWAS) have identified statistically significant association of the PICALM rs3851179 polymorphism with AD. The PICALM G allele increases the risk of AD, while the A allele has a protective effect. We examined the association of the PICALM rs3851179 polymorphism with parameters of the P3 component of auditory event-related potentials (ERPs) in 87 non-demented volunteers (age, 19-77 years) subdivided into two cohorts younger and older than 50 years of age. We found statistically significant association between the AD risk variant PICALM GG and increase in the P3 latency in subjects over 50 years old. The age-dependent increase in the P3 latency was more pronounced in the PICALM GG carriers than in the carriers of the PICALM AA and PICALM AG genotypes. The observed PICALM-associated changes in the neurophysiological processes indicate a decline in the information processing speed with aging due, probably, to neuronal dysfunction and subclinical neurodegeneration of the neuronal networks in the hippocampus and the frontal and parietal cortical areas. Such changes were less pronounced in the carriers of the PICALM gene A allele, which might explain the protective effect of this allele in the cognitive decline and AD development.

Blast exposure impairs sensory gating: Evidence from measures of acoustic startle and auditory event-related potentials

Many military Veterans who have been exposed to high-intensity blast waves suffer from traumatic brain injury (TBI), resulting in chronic auditory deficits despite normal hearing sensitivity. The current study examined the neurological cause of this chronic dysfunction by testing the hypothesis that blast exposure leads to impaired filtering of sensory information at brainstem and early cortical levels. Groups of blast-exposed and non-blast-exposed participants completed self-report measures of auditory status, auditory perceptual tasks, and physiological measures of sensory gating, including prepulse-inhibition and habituation of the acoustic startle reflex and electrophysiological assessment of a paired-click sensory gating paradigm. Blast-exposed participants showed significantly reduced habituation to acoustic startle stimuli and impaired filtering of redundant sensory information at the level the auditory cortex. Linear regression analyses revealed that poorer sensory gating at the cortical level was primarily influenced by a diagnosis of TBI, while reduced habituation was primarily influenced by a diagnosis of posttraumatic stress disorder. A statistical model was created including cortical sensory gating and habituation to acoustic startle, which strongly predicted performance on a degraded speech task. These results support the hypothesis that blast exposure impairs central auditory processing via impairment of neural mechanisms underlying habituation and sensory gating.

Brain Processing (Auditory Event-Related Potential) of Stressed Versus Unstressed Words in Thai Speech.

This study investigated the effect of the stressed word in Thai language on auditory event-related potential (aERP) in unattended conditions. We presented 30 healthy participants with monosyllabic Thai words consisting of either stressed or unstressed words. We instructed them not to attend to the sound stimuli, but rather to watch and memorize the contents of a silent natural documentary without subtitles. The two listening conditions consisted of 20% deviant stimuli (70 stressed and 70 unstressed words, respectively) and 80% standard stimuli (other 280 unstressed words) presented pseudorandomly and binaurally via a pair of earphones. Participants' aERPs from the two conditions were evaluated by the mismatch negativity (MMN) component of aERP. The mismatch negativity amplitudes in the stressed word condition were significantly higher than those in the unstressed word condition, especially in frontal and left fronto-central brain areas. Therefore, these data show the role of the frontal and left fronto-central brain regions in auditory preattentive processing of stressed word perception among native Thai speakers. This is the first study demonstration that stressed meaningful monosyllable words in tonal language facilitate word perception in this preattentive stage. This result has implications for developing clinical tests evaluating preattentive speech perception.

Auditory Event-Related Potentials Associated With Music Perception in Cochlear Implant Users.

A short review of the literature on auditory event-related potentials and mismatch negativities (MMN) in cochlear implant users engaged in music-related auditory perception tasks is presented. Behavioral studies that have measured the fundamental aspects of music perception in CI users have found that they usually experience poor perception of melody, pitch, harmony as well as timbre (Limb and Roy, 2014). This is thought to occur not only because of the technological and acoustic limitations of the device, but also because of the biological alterations that usually accompany deafness. In order to improve music perception and appreciation in individuals with cochlear implants, it is essential to better understand how they perceive music. As suggested by recent studies, several different electrophysiological paradigms can be used to reliably and objectively measure normal-hearing individuals' perception of fundamental musical features. These techniques, when used with individuals with cochlear implants, might contribute to determine how their peripheral and central auditory systems analyze musical excerpts. The investigation of these cortical activations can moreover give important information on other aspects related to music appreciation, such as pleasantness and emotional perception. The studies reviewed suggest that cochlear implantation alters most fundamental musical features, including pitch, timbre, melody perception, complex rhythm, and duration (e.g., Koelsch et al., 2004b; Timm et al., 2012, 2014; Zhang et al., 2013a,b; Limb and Roy, 2014). A better understanding of how individuals with cochlear implants perform on these tasks not only makes it possible to compare their performance to that of their normal-hearing peers, but can also lead to better clinical intervention and rehabilitation.