This study introduces an advanced dual-mode compound attitude control framework for reusable launch vehicles (RLVs), underpinned by an enhanced particle swarm optimization (PSO) algorithm. This innovative strategy is tailored to meet the stringent demands for precision and robust anti-interference capabilities across the entire flight envelope of RLVs. The research commences with the formulation of a comprehensive attitude dynamics model and diverse heterogeneous actuator representations, meticulously crafted to reflect the distinct phases of RLV flight. Building upon this foundation, a synergistic control paradigm is engineered, integrating PID and fuzzy PID controllers and dynamically adjusting the inertia weights and learning factors of the PSO algorithm to achieve the balance between global and local optimization performance, complemented by a refined fitness evaluation function. The crux of the study is the application of an upgraded PSO algorithm to fine-tune the controllers’ weighting coefficients, culminating in an optimized dual-mode compound attitude control system. A series of comparative simulation analyses are thoroughly executed to appraise the system’s responsiveness, stability, precision, and resilience to interference. The simulation outcomes demonstrate an average reduction of 42.21% in step response overshoot, an 18.52% decrease in settling time, a 53.18% decline in steady-state error, a 56.80% drop in the maximum deviation value, a 55.82% improvement in recovery speed, and a 75.61% enhancement in tracking precision for the proposed controller. The findings clearly verify the superior performance of the proposed control system, affirming its contribution to the advancement of RLV attitude control. The proposed controller holds promising potential for real application in attitude control systems and is poised to augment the reliability and mission success rate of RLVs under intricate flight scenarios.