Abstract2D hybrid perovskites have emerged as a promising alternative material to address the environmental stability and the ion‐migration of the 3D perovskites for direct X‐ray detector applications. Nevertheless, the X‐ray detection performance of the 2D hybrid perovskites still lags because of its low X‐ray attenuation ability and limited solubility for thick film deposition. Here, a high‐performance X‐ray detector in Dion‐Jacobson 2D hybrid perovskite, 2(aminomethyl) pyridinium lead bromide (2AMPPbBr4), is studied. 2AMPPbBr4 exhibits an ultra‐short interlayer distance of 3.43 Å, leading to high X‐ray attenuation ability. Furthermore, DFT results indicate that 2AMPPbBr4 exhibits type II band alignment between 2AMP2+ ligand and the [PbI6]4− layers, facilitating effective spatial separation of photo‐generated carriers. The X‐ray detector made of 2AMPPbBr4 with an average thickness of 200 µm is realized via an improved drop‐casting method. An improved X‐ray sensitivity of 3933.88 µC Gy−1 cm−2 and a low detection limit of 4.17 nGy s−1 is achieved. This work paves the way for high‐performance X‐ray detectors based on the emerging 2D perovskite materials.