Simulation of the vertical profile of methane concentration in the Earth’s atmosphere is simulated in the absence of direct visibility on the spacecraft (SC)-Earth surface route. At high latitudes, clouds cover the Earth’s surface for a significant time, so it is important to use all possibilities so that there are no significant windows of uncertainty in data acquisition along the entire path, including the lower troposphere. For modeling purposes the vertical profile of methane concentration was approximated by a sixth-degree polynomial, and the profile was refined by varying its coefficients until is coincide with the experimental data. The proposed method of using the reflected and scattered signal from clouds and cloud formations and extrapolating data along the vertical profile of methane to the entire path in the absence of direct visibility of the Earth’s surface ensures uninterrupted data acquisition, thereby increasing the accuracy and reliability of statistical materials for determining the methane concentration, and, consequently, its influence on the dynamics of the climate in general.