We retrospectively analyzed the clinical manifestations, treatments and prognosis of infective endocarditis (IE)associated with renal lesions in children. There were 23 confirmed IE cases who were admitted to the Capital Institutes of Pediatrics from 1992 to 2012. There were 6 cases (26%) with renal lesions. Renal lesions included asymptomatic microscopic hematuria(1 case), asymptomatic proteinuria(1 case) and acute nephritic syndrome (4 cases). There were 3 cases of acute renal injury (AKI) resulted from nephritis accompanied with acute heart failure. The serum level of C3 was lower in patients with renal lesions than patients without renal lesions (P 0.05). Renal lesions secondary to IE are relatively common in IE patients in children. Most of renal lesions can be improved by effective antibiotics. Prognosis of those patients accompanying with AKI is bad. Key words: Endocarditis; Kidney disease