Abstract Transiting planets in multiple-star systems, especially high-order multiples, make up a small fraction of the known planet population but provide unique opportunities to study the environments in which planets would have formed. Planet-hosting binaries have been shown to have an abundance of systems in which the stellar orbit aligns with the orbit of the transiting planet, which could give insights into the planet formation process in such systems. We investigate here if this trend of alignment extends to planet-hosting triple-star systems. We present long-term astrometric monitoring of a novel sample of triple-star systems that host Kepler transiting planets. We measured orbit arcs in 21 systems, including 12 newly identified triples, from a homogeneous analysis of our Keck adaptive optics data and, for some systems, Gaia astrometry. We examine the orbital alignment within the nine most compact systems (≲ 500 au), testing if either (or both) of the stellar orbits align with the edge-on orbits of their transiting planets. Our statistical sample of triple systems shows a tendency toward alignment, especially when assessing the alignment probability using stellar orbital inclinations computed from full orbital fits, but is formally consistent with isotropic orbits. Two-population tests where half of the stellar orbits are described by a planet-hosting-binary-like moderately aligned distribution give the best match when the other half (non-planet-hosting) has a Kozai-like misaligned distribution. Overall, our results suggest that our sample of triple-star planet-hosting systems are not fully coplanar systems and have at most one plane of alignment.