Association Of Mean Platelet Volume Research Articles

Abstract WMP56: Association of Mean Platelet Volume and Its Genetic Variants With Stroke Severity and One-year Mortality in a Polish Stroke Cohort

Background: Increased mean platelet volume (MPV) is a marker of worse outcomes in cardiovascular disorders, however its prognostic role in patents with ischemic stroke and possible genetic underpinnings remains uncertain. We aimed to determine whether MPV and selected single nucleotide polymorphisms (SNPs) that have been associated with MPV in genome-wide association studies (GWAS) relate to stroke severity, functional outcome on discharge, and one-year mortality in patients with ischemic stroke. Methods: We retrospectively analyzed 577 patients with first ever ischemic stroke. Genotyping of 3 SNPs (rs342293, rs1354034, rs7961894) was performed using a real-time polymerase chain reaction allelic discrimination assay. Multivariable regression was used to determine the association of MPV and MPV-associated SNPs with the National Institutes of Health Stroke Scale (NIHSS) score on admission, modified Rankin Scale (mRS) on discharge, and data on one-year mortality. Results: Rs7961894, but not rs342293 and rs1354034 SNP, was independently associated with MPV in the highest quartile (MPV Q4). MPV Q4 was associated with significantly greater admission NIHSS (p=0.004), poor discharge outcome (p=0.034), and worse one-year mortality (p=0.033). After adjustment for pertinent covariates, MPV Q4 remained independently associated with a greater admission NIHSS score (p=0.025). Patients carrying T>C variant of rs7961894 SNP had a significantly lower one-year mortality as compared to patients with CC genotype (p=0.029; Log-Rank test; Fig.1) and T>C variant of rs7961894 SNP remained an independent marker of a lower one-year mortality (HR=0.30; 95%CI:0.13-0.70; p=0.006) in the studied population. Conclusion: MPV is a marker of stroke severity and rs7961894 is independently associated with MPV in acute phase of ischemic stroke and relates to one-year mortality after stroke.

The association of mean platelet volume and platecrit and bone marrow fibrosis in patients with essential thrombocythemia: A cohort study

Amac: Esansiyel trombositemi (ET) hastalarinda ortalama trombosit hacmi (MPV) degerleri saglikli bireylere gore daha yuksek seyretmektedir. Ancak, ET’da MPV veya plateletkritin (PCT) kemik iligi fibrozisi (KIF) derecesi ile iliskisi henuz arastirilmamistir. Amacimiz MPV ve PCT degerlerinin ET hastalarinda kemik iligi fibrozisini degerlendirmede prediktif bir belirtec olarak rolunu arastirmaktir. Yontemler: Retrospektif bir kohort calismasi yaparak Ocak 2015 ile Aralik 2016 arasinda hematoloji poliklinigimizden takip edilen ET hastalarinin verilerini inceledik. 18 yasindan buyuk, tani aninda kemik iligi biyopsisi, hemogram, biyokimya ve batin ultrasonu olan, JAK2 istenmis olan ve BCR-ABL negatif hastalar calismaya dâhil edildi. Hastalar KIF varligina gore “KIF grubu” ve “KIF olmayan grup” olarak iki gruba ayrildi. MPV ve PCT icin esik deger icin ortanca deger alindi. Karsilastirmali istatistiksel analizler icin Fisher exact ve ki kare testi kullanildi. Bulgular: Hastalarin 22’si erkek 26’si kadin olup ortanca yas 56 yasti (Aralik 28-81). KIF grubunda 35 (%73) hasta varken KIF olmayan grupta 13 (%27) hasta mevcuttu. Medyan MPV 8,8 fL (6,6-11,5) iken medyan PCT %0,69 (0,42-2,26) idi ve bunlar iki parametre icin esik deger olarak kullanildi. KIF varligi ile MPV ≤8,8 fL ve MPV >8,8 fL olan hastalar arasinda, PCT ≤%0,69 ve PCT >%0,69 olanlardaki gibi anlamli fark bulunmamaktaydi (p=0,104 ve 0,616). Sonuc: Calismamizda ET hastalarinda KIF ile MPV veya PCT arasinda iliski bulamadik. Bununla birlikte calismamiz ET hastalarinda KIF’ni ongormede MPV ve PCT’nin rolunu arastiran ilk calismadir.

The Mean Platelet Volume in the Prognosis of Coronary Artery Disease Severity and Risk Stratification of Acute Coronary Syndromes.

Introduction:Platelets play a crucial role in thrombotic episodes. Mean Platelet Volume (MPV) is the primary indicator of platelet’s activation; its measurement is easy and time-effective.Aim:We tested the hypothesis that MPV is correlated with SYNTAX score in patients that suffered from an Acute Coronary Syndrome (ACS).Material and Methods:One hundred and four (104) patients (79 male–25 female, mean age 64.2±11.1 years), who were hospitalized for an ACS and underwent coronary angiography, were included in the study. Syntax score, as an indicator of the severity of coronary artery disease (CAD), was calculated. We tried to investigate the correlation between the first measured MPV, CRP, Creatinine and high sensitivity Troponin with the Syntax score of the patient and the association of MPV and a possible Major Advanced Cardiac Event (MACE) during hospitalization.Results:The patients were divided into four groups according to the SYNTAX score: Group A (SYNTAX score: 0, n=12), group B: Mild CAD (SYNTAX score: 1–22, n=68), group C: Moderate CAD (SYNTAX score: 23–32, n=12), and group D: Severe CAD (SYNTAX score: ≥ 33, n=12). Four patients (3.8%) developed a MACE during their hospitalization. MPV was significantly correlated to Syntax score (r=0.658, p<0.001) and was found to be an independent predictor factor of MACE with HR=6.8 (95% Confidence Interval 1.46-33.36). The cut-off value of MPV was 7.5 with a sensitivity of 98% and a specificity of 30.8%.Conclusion:We determined a positive correlation between MPV and Syntax score, transforming this simple test in a possible factor of risk stratification in ACS.

Reply to: Comment on "Association of mean platelet volume with echocardiograffiric findings in patients with severe rheumatic mitral stenosis".

Reply to: Comment on "Association of mean platelet volume with echocardiograffiric findings in patients with severe rheumatic mitral stenosis".

Comment on "Association of mean platelet volume with echocardiograffiric findings in patients with severe rheumatic mitral stenosis".

Comment on "Association of mean platelet volume with echocardiograffiric findings in patients with severe rheumatic mitral stenosis".

Association of mean platelet volume with echocardiographic findings in patients with severe rheumatic mitral stenosis.

Introduction: Rheumatic heart disease (RHD) is a relatively common cause of mortality among patients in the developing countries, and pure mitral valve failure is the most common form of RHD. An increase in the mean platelet volume (MPV) is considered as an independent risk factor for many cardiovascular diseases. This study aimed to evaluate the association of MPV with echocardiographic findings in patients with severe rheumatic mitral stenosis. Methods: In a descriptive, analytical study, 100 patients with severe rheumatic mitral stenosis referred to Shahid Madani hospital of Tabriz University of Medical Sciences and 100 age & sex-matched healthy individuals were included the study. MPV and echocardiographic findings including Wilkins score, left ventricular ejection fraction (LVEF), pulmonary artery systolic pressure, and left atrial spontaneous echo contrast (LASEC) were evaluated in both groups. Results: MPV in the case group was 10.45±0.98 and in the control group was 9.88±0.83. MPV in the patient’s groups was significantly higher than the control group (P = 0.001). Also, MPV in patients with positive LASEC findings was 10.69 ± 1.01 and in patients with negative LASEC findings was 10.25 ± 0.91. The difference was found to be statistically significant (P = 0.028). Conclusion: Patients with rheumatic mitral stenosis has a higher MPV compared to the healthy individuals, and it is associated with LASEC sign seen in echocardiography.

Effects of Preoperative Mean Platelet Volume on Early Outcomes of Patients After Conventional Coronary Artery Bypass Graft Surgery

An elevated mean platelet volume is associated with increased platelet activation and thus may predict thrombotic events including major cardiac adverse events after CABG surgery. The association of mean platelet volume with in-hospital outcome of patients after coronary artery bypasses grafting surgery was investigated in this study. Preoperative mean platelet volume was obtained prospectively in 8^ consecutive patients undergoing conventional coronary artery bypass surgery. Postoperative mortality and major adverse events were recorded in the early postoperative Period. Combined adverse events including post operative Myocardial Infarction (Ml), arrhythmia, bleeding and death occurred in 27 patients (33.3%) during the early follow-up. The preoperative mean platelet volume levels were found to be associated with postoperative adverse events (p&lt;0.05). In multivariate logistic regression models, the preoperative mean platelet voluue levels was found strong independent predictor of combined adverse events after surgery (OR 1.968, p=0.008).University Heart Journal Vol. 14, No. 1, Jan 2018; 24-27

Association of Mean Platelet Volume in the Late First Trimester of Pregnancy and Development of Preeclampsia

Association of Mean Platelet Volume in the Late First Trimester of Pregnancy and Development of Preeclampsia

Association of mean platelet volume with incident type 2 diabetes mellitus risk: the Dongfeng\u2013Tongji cohort study

BackgroundMost of prior studies to demonstrate the association between mean platelet volume (MPV) and type 2 diabetes mellitus (T2DM) risk were cross-sectional design with inconsistent results. In the present prospective cohort study, we aimed to explore the relationship between MPV and incident T2DM risk among a middle-aged and older Chinese population.MethodsThis prospective study included 14,009 individuals derived from the Dongfeng–Tongji cohort which was launched in 2008. A total of 997 incident T2DM patients were diagnosed during the mean 4.51 years of follow-up period. MPV levels were divided into quartiles. The adjusted hazard ratios (HRs) and 95% confidence intervals (95% CIs) of incident T2DM was estimated by Cox proportional hazard models.ResultsCompared with study participants with MPV < 7.49 fL, the HRs of T2DM incidence were 1.39 (95% CI 1.11–1.75), 1.14 (0.90–1.44), and 1.39 (95% CI 1.07–1.81) in study participants with 7.49 ≤ MPV < 8.43 fL, 8.43 fL ≤ MPV < 9.69 fL and MPV ≥ 9.69 fL, respectively. This positive association was more pronounced after exclusion of the newly diagnosed incident cases during the first 2 years follow-up. Further adjustment for baseline fasting blood glucose level (FBG) did not materially alter the positive association. The positive association was particularly evident among females, non-current smokers and study participants with FBG level less than 5.6 mmol/L at baseline.ConclusionHigher levels of MPV were independently associated with increased incident risk of T2DM in a middle-aged and older Chinese population.

Association of Mean Platelet Volume and Fibrinogen with Major Cardiovascular Events in Acute Coronary syndrome

Association of Mean Platelet Volume and Fibrinogen with Major Cardiovascular Events in Acute Coronary syndrome

Association of mean platelet volume and red blood cell distribution width with coronary collateral development in stable coronary artery disease.

IntroductionThe prognostic value of hematological indices in cardiovascular diseases and the association between these parameters and cardiovascular conditions have been established in the literature.AimIn this study, we aimed to investigate the relation of mean platelet volume (MPV), MPV to platelet ratio (MPR) and red cell distribution width (RDW) with degree of coronary collateral development (CCD) in stable coronary artery disease (CAD) subjects with established critical coronary artery stenosis.Material and methodsA total of 306 patients with stable angina pectoris undergoing coronary arteriography were enrolled and divided on the basis of the development of CCD into two groups: a group with adequate CCD (n = 214) and a group with impaired CCD (n = 92). Routine complete blood count and biochemical parameters were measured before coronary arteriography.ResultsThe MPV and MPR levels were significantly higher in the inadequate CCD group (10.5 ±1.8 fl vs. 8.7 ±1.9 fl, p < 0.001 and 0.06 ±0.08 vs. 0.05 ±0.07, p = 0.036). Patients with inadequate CCD had significantly higher RDW levels compared to patients with adequate CCD (15.5 ±1.7% vs. 15.0 ±1.9%, p = 0.01). MPV and RDW were significantly associated with Rentrop collateral grading (r = –0.523, p < 0.001 and r = –0.239, p < 0.001, respectively), whereas the association with MPR was not significant. An MPV value greater than 9.95 fl, determined with ROC curve analysis, had 71% sensitivity and 70% specificity in predicting inadequate CCD. An RDW greater than 14.3% has 71% sensitivity and 53% specificity in selecting patients with adequate CCD.ConclusionsThe present study suggests that MPV and MPR may be associated with the degree of collateral development in chronic stable CAD. However, the negative association of RDW with inadequate CCD, in combination with previous contradictory reports, raises a doubt about the possible value of RDW in stable CAD. Although these parameters may be affected by various conditions, a high MPV may lead clinicians to suspect possible inadequate collateral development in stable CAD patients.

Association of Mean Platelet Volume and Platelet Distribution Width with Hba1c

Diabetes mellitus type 2 (DMT2) is a metabolic disorder, and its prevalence is rising worldwide. The objective of the study was to investigate association of mean platelet volume (MPV) and platelet distribution width (PDW) with glycemic control marker HbA1c.

Blood Platelet Volume Represents a Novel Prognostic Factor in Patients with Nonmetastatic Renal Cell Carcinoma and Improves the Predictive Ability of Established Prognostic Scores.

The average size of blood platelets determined by mean platelet volume might represent a biologically meaningful parameter in carcinogenesis and potentially serve as a novel prognostic biomarker in renal cell carcinoma. In this retrospective analysis of the records of 652 patients we evaluated the potential prognostic value of mean platelet volume and its ability to improve existing risk assessment tools used in adjuvant clinical trials in nonmetastatic renal cell carcinoma cases. Associations of mean platelet volume with baseline covariates and clinical outcomes (recurrence, and death from renal cell carcinoma and other causes) were assessed with the competing risk estimators of Kaplan-Meier, and Marubini and Valsecchi, respectively. Univariable and multivariable Cox proportional hazard models were constructed. The Harrell c-index was applied to test improvements in the predictive accuracy of the established Leibovich prognosis score. Small platelet volume was associated with large tumors (p = 0.043), high Fuhrman grade (p = 0.001), sarcomatoid components (p <0.0001), histological tumor necrosis (p = 0.044) and vascular invasion (p = 0.022). On univariable and multivariable analyses small platelet volume accurately predicted recurrent renal cell carcinoma (continuously and binary coded) and cancer specific survival. Adding mean platelet volume to the Leibovich prognosis score improved its discriminative performance (c-index = 0.83, p = 0.004). Mean platelet volume represented a highly significant predictor of recurrence and cancer specific death in patients with renal cell carcinoma. This parameter improved the accuracy of the Leibovich prognosis score to better predict long-term outcomes in localized renal cell carcinoma cases after curative surgical resection.

Association of mean platelet volume with presence of non-viable myocardium in ischaemic cardiomyopathy.

Parameters derived from complete blood count, such as mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), have recently been proposed as measures of inflammation in addition to C-reactive protein (CRP), a classical inflammatory marker. Significant association of these parameters with atherosclerosis and complications have increasingly been reported. The aim of the study is to evaluate the relationship between these parameters and the presence of myocardial viability assessed with positron emission tomography (PET) in patients with ischaemic cardiomyopathy (ICM). A total of 122 ICM patients who had undergone PET were enrolled in this study. The patients were dichotomised depending on the presence of transmural scar. Group 1 consisted of 21 patients who had transmural scar tissue only, who were accepted as the group having non-viable myocardium. Group 2 consisted of 101 patients who had hibernation and/or non-transmural scar, who were accepted as the group having viable myocardium. Haematological parameters within 30 days of PET imaging were retrospectively analysed. There were no significant differences between the two groups regarding values of white blood cell, neutrophil, lymphocyte, platelet, haemoglobin, red cell distribution width, CRP, PLR, and NLR. Patients with non-viable myocardium have significantly higher levels of MPV (p = 0.002). In multiple logistic regression analysis, MPV (odds ratio [OR] = 0.373, 95% confidence interval [CI] 0.20-0.69, p = 0.002), was identified as an independent predictor of non-viable myocardium. In receiver-operator characteristic (ROC) analysis, a cut-point of 8.19 identified patients with non-viable myocardium (area under curve: 0.72, 95% CI 0.60-0.84). An MPV value greater than 8.19 demonstrated a sensitivity of 76% and a specificity of 55%. \ CONCLUSIONS: The present study showed that MPV is an inexpensive, clinical, and routinely measurable parameter that is associated with the presence of viable myocardium in ICM.

Abstract TP202: Association of Rs7961894 with Mean Platelet Volume in Patients with Acute Ischemic Stroke

Introduction: Mean platelet volume (MPV) is a marker of platelet function and elevated MPV was found to be an independent risk factor for death after myocardial infarct in patients with coronary artery disease. Higher MPV was associated with increased risk of ischemic stroke, yet there is insufficient data regarding the role of MPV as a marker of outcome in patients with ischemic stroke. The variability of platelet indices in humans is largely determined by genetic factors and rs7961894 located within intron 3 of WDR66 gene showed the strongest association with MPV in all genome wide association (GWA) studies in the European population. Aim: To determine the association of rs7961894 with MPV in patients with acute ischemic stroke and to assess whether rs7961894 and MPV could be markers of one year mortality in different stroke subtypes. Material and methods: For 426 adults with first-ever ischemic stroke MPV was measured within 72h of stroke onset and single nucleotide polymorphism genotyping of rs7961894 was performed accordingly (RT-PCR, Applied Biosystems). Epidemiologic and clinical characteristics (including TOAST classification), laboratory findings as well as one year mortality data were collected for each participant. Results: Allele T and genotypes CT and TT of the rs7961894 polymorphism were associated with the highest (&gt;11.5fL) MPV quartile (Chi 2 test, p&lt;0.01). MPV was significantly higher in patients with genotype TT as compared to CT and CC genotype (12.0±0.24fL vs. 11.10±0.15fL and 10.77±0.05fL, respectively, ANOVA, p &lt;0.005 with Tukey HSD post-hoc test, Figure 1). Conclusions: Allele T of rs7961894 polymorphism is associated with increased MPV in the recessive and dominant model and patients with genotype TT have significantly higher MPV as compared to the rest of the population study. Further analysis is currently being conducted to determine the association of MPV and rs7961894 polymorphism with one year mortality and stroke subtypes.

A Study of Association of Mean Platelet Volume and Ischaemic Stroke

A Study of Association of Mean Platelet Volume and Ischaemic Stroke

The independent association of mean platelet volume with overall survival in multiple myeloma.

We retrospectively analyzed the association between mean platelet volume (MPV) and prognosis in 62 newly diagnosed multiple myeloma (MM) patients. The associations between MPV and clinical characteristics were assessed. The log-rank test and the Cox proportional hazards model were used to evaluate the effect of MPV on survival. A MPV value of 8.50 fl was considered to be the optimal cut-off value for prognosis. MPV was associated with IgA isotype (P=0.012), serum creatinine concentration > 176.8 μmol/L (P=0.025) and IgH rearrangement (P=0.008). The log-rank test demonstrated that patients with low MPV experienced a shorter overall survival (OS) (P=0.0397). The multivariate analysis demonstrated that low MPV was an independent prognostic factor for OS [hazard ratio (HR)=2.44, P=0.026]. Therefore, we demonstrated that low MPV predicted an unfavorable prognosis in patients with MM.

Association of mean platelet volume with impaired myocardial reperfusion and short-term mortality in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.

Impaired myocardial reperfusion, defined angiographically by myocardial blush grade (MBG) 0 or 1, is associated with adverse clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI). The aim of this study was to investigate the impact of admission mean platelet volume (MPV) on the myocardial reperfusion and 30-day all-cause mortality in patients with STEMI with successful epicardial reperfusion after primary percutaneous coronary intervention (PCI). A total of 453 patients with STEMI who underwent primary PCI within 12 h of symptoms onset and achieved thrombolysis in myocardial infarction (TIMI) 3 flow at infarct-related artery after PCI were enrolled and divided into two groups based on postinterventional MBG: those with MBG 2/3 and those with MBG 0/1. Admission MPV was measured before coronary angiography. The primary endpoint was all-cause mortality at 30 days. MPV was significantly higher in patients with MBG 0/1 than in patients with MBG 2/3 (10.38 ± 0.98 vs. 9.59 ± 0.73, P < 0.001). The cumulative 30-day all-cause mortality rate was significantly higher in the groups with high MPV and MBG 0/1 (6.8 vs. 1.5%, P = 0.005, 7.6 vs. 1.9%, P = 0.006, respectively). Multivariate logistic regression analysis demonstrated MPV was independently associated with postinterventional impaired myocardial reperfusion (odds ratio 2.684, 95% confidence interval 2.010-3.585, P < 0.001) and 30-day all-cause mortality (hazard ratio 1.763, 95% confidence interval 1.009-3.079, P = 0.046). Increased MPV on admission is an independent predictor of impaired myocardial reperfusion and short-term mortality in patients with STEMI with successful epicardial reperfusion after primary PCI. Admission MPV may be additive to conventional risk factors in patients with STEMI undergoing PCI.

The relationship of mean platelet volume with microalbuminuriain type 2 diabetic patients.

Activation and size of platelets have been suggested to be involved in the pathogenesis of vascular complications in diabetes mellitus. The purpose of the present study was to investigate the association of mean platelet volume with microalbuminuria in type 2 diabetic patients. Mean platelet volume levels were investigated in healthy participants and type 2 diabetic patients with and without microalbuminuria. After their mean platelet volume values were compared, correlation of mean platelet volume with sex, duration of diabetes, microalbuminuria, fasting blood glucose, hemoglobin A1c, creatinine clearance, and body mass index was examined. Mean platelet volume levels were higher in all diabetic patients than those in controls. Mean platelet volume levels were highest in diabetics with microalbuminuria. The mean platelet volume levels had a positive correlation with microalbuminuria. Mean platelet volume values of diabetic patients were higher than those of nondiabetics, the highest levels being in diabetics with microalbuminuria. Our results suggest that microalbuminuria might be related with mean platelet volume in diabetic patients.

The relationship between mean platelet volume and coronary collateral vessels in patients with acute coronary syndromes

Background: Elevated mean platelet volume (MPV) has been proposed as a risk factor for coronary artery disease (CAD) and is associated with poor clinical outcome in acute coronary syndrome (ACS). However, some studies have contradictory findings. Hence, we aimed to evaluate the association of MPV with the presence of coronary collateral vessel (CCV) in patients with ACS. Objective: To find MPV value in ACS patients and to find the predictive value of MPV in the spectrum of CAD and to examine whether levels of MPV predict the presence of CCVs. Methods: A total of 180 patients with first ACS were included in the study. MPV was measured. All patients underwent coronary angiography to know disease severity and CCVs. The CCVs are graded according to the Rentrop scoring system and according to coronary angiography results; patients were divided into two groups as Group 1 (poor CCV) and Group 2 (good CCV). Results: The MPV was 10.74 ± 2 fl in poor collateral group patients and 11.01 ± 1.7 fl in good collateral group (P = 0.421). The presence of CCV was not significantly associated with high levels of MPV. MPV value did not show any prediction of the spectrum of CAD. Conclusion: MPV on admission was not associated with the development of CCV positively in patients with ACS. Furthermore, it is not associated with a number of vessel involvements.