Abstract
Introduction: Rheumatic heart disease (RHD) is a relatively common cause of mortality among patients in the developing countries, and pure mitral valve failure is the most common form of RHD. An increase in the mean platelet volume (MPV) is considered as an independent risk factor for many cardiovascular diseases. This study aimed to evaluate the association of MPV with echocardiographic findings in patients with severe rheumatic mitral stenosis. Methods: In a descriptive, analytical study, 100 patients with severe rheumatic mitral stenosis referred to Shahid Madani hospital of Tabriz University of Medical Sciences and 100 age & sex-matched healthy individuals were included the study. MPV and echocardiographic findings including Wilkins score, left ventricular ejection fraction (LVEF), pulmonary artery systolic pressure, and left atrial spontaneous echo contrast (LASEC) were evaluated in both groups. Results: MPV in the case group was 10.45±0.98 and in the control group was 9.88±0.83. MPV in the patient’s groups was significantly higher than the control group (P = 0.001). Also, MPV in patients with positive LASEC findings was 10.69 ± 1.01 and in patients with negative LASEC findings was 10.25 ± 0.91. The difference was found to be statistically significant (P = 0.028). Conclusion: Patients with rheumatic mitral stenosis has a higher MPV compared to the healthy individuals, and it is associated with LASEC sign seen in echocardiography.
Highlights
Rheumatic heart disease (RHD) is a relatively common cause of mortality among patients in the developing countries, and pure mitral valve failure is the most common form of RHD
Yavuz et al studied the relationship between mean platelet volume (MPV) and vascular events in patients with rheumatic mitral stenosis (RMS) and showed that MPV was significantly higher in patients compared to the healthy controls
We showed that MPV was significantly higher in the patients’ group than the control group (P = 0.001) (Table 1)
Summary
Rheumatic heart disease (RHD) is a relatively common cause of mortality among patients in the developing countries, and pure mitral valve failure is the most common form of RHD. Rheumatic heart disease (RHD) is still amongst the most common cardiovascular diseases in children and adolescents in the developing countries.[1,2] Pure mitral valve failure is the most common form of RHD being affected in about 85% of cases.[3] One of the complications of mitral stenosis (MS) is thromboembolism (TE), and various factors have been found to be associated with increased risk of TE in this regard.[4,5,6] These factors include, but are not limited to, age, mitral valve surface size, atrial fibrillation (AF), low blood flow in the left atrium, and spontaneous echo contrast (SEC), i.e., swirling motion of the blood in the echocardiography of the left atrium. Varol et al showed that MPV was significantly higher in patients with RMS than the control group.[11]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
