Research Quality Assessment Research Articles

Review Paper on a Study on SQL Attacks and Defense

In today's era, every person is utilizing websites and so many different web applications for online administrations, for example booking of railway tickets, movie ticketing, shopping, communication, and so forth. These websites consist sensitive and confidential information. With the linearity of web applications in the last decade, the unconstructive crash of security has also matured either. SQL injection attack is one such attack where the anonymous user can append SQL code to the input query. This research paper starts with developing criteria for a systematic literature review based on research questions, quality assessment, and data samples. The paper presents various SQL injection techniques with their intended attacks. Further studies explore different techniques to prevent attacks. Existing vulnerabilities of Web systems threaten the regular work of information systems. The most common Web system vulnerability is SQL injection. There are known approaches to protect Web applications against SQL injection attacks in the article. To improve the Web software security is developed defense mechanism that protects Web resources from SQL injection performing. To implement this software it is used PHP, JavaScript, and formal language theory known as regular expressions. As a result, it is received a software tool that allows protecting Web software from SQL injection vulnerability. The developed software tool allows users to protect their Web applications from an attack using SQL.

Establishment of a Fuzzy Comprehensive Evaluation Random Matrix Model for the Assessment of Foreign Language Translation Level in Universities

In this paper, the random matrix method of a fuzzy comprehensive evaluation is used to conduct in-depth research and analysis on the assessment of foreign language translation levels in universities, and the corresponding model is designed for the automatic assessment of translation levels in university education. The Hessian matrix of the second-order optimization method is used to analyze the geometric properties of the loss plane of the deep neural network, and it is proved that the Hessian matrix can be constructed as a sample covariance matrix, which is the classical Wishart matrix in the random matrix theory. Using the study on the asymptotic distribution properties of the Wishart matrix in random matrix theory, the Hessian matrix is analyzed and the limiting spectral distribution, the eigenvalue extreme value distribution, and the standard conditional number distribution of the matrix are given. And the scores are basically distributed above 240, but some indicators have relatively low scores, all below 120 points, so the indicators distributed above 240 points are selected as reserved indicators. The analysis considers that the evaluation of foreign language translation in learning in colleges and universities is itself very fuzzy and constructs an evaluation model based on the fuzzy comprehensive judgment method, which provides a research strategy for the future evaluation of foreign language translation in learning in colleges and universities. Finally, the evaluation system of foreign language translation in learning in colleges and universities is designed and implemented. It is feasible to apply the fuzzy comprehensive judgment to the comprehensive evaluation of college students, the combined judgment of multiple methods has higher reliability and stability, and its research conclusions have certain reference value in the specific education management practice. The value, objectivity, feasibility, and wide adaptability of the fuzzy comprehensive evaluation method are analyzed, and some references are expected to be provided for translation quality assessment research and translation practice.

Alteration of RNA modification signature in human sperm correlates with sperm motility.

RNA modifications, which are introduced post-transcriptionally, have recently been assigned pivotal roles in the regulation of spermatogenesis and embryonic development. However, the RNA modification landscape in human sperm is poorly characterized, hampering our understanding about the potential role played by RNA modification in sperm. Through our recently developed high-throughput RNA modification detection platform based on liquid chromatography with tandem mass spectroscopy, we are the first to have characterized the RNA modification signature in human sperm. The RNA modification signature was generated on the basis of 49 samples from participants, including 13 healthy controls, 21 patients with asthenozoospermia (AZS) and 15 patients with teratozoospermia (TZS). In total, we identified 13 types of RNA modification marks on the total RNA in sperm, and 16 types of RNA modification marks on sperm RNA fragments of different sizes. The levels of these RNA modifications on the RNA of patients with AZS or TZS were altered, compared to controls, especially on sperm RNA fragments >80 nt. A few types of RNA modifications, such as m1G, m5C, m2G and m1A, showed clear co-expression patterns as well as high linear correlations with clinical sperm motility. In conclusion, we characterized the RNA modification signature of human sperm and identified its correlation with sperm motility, providing promising candidates for use in clinical sperm quality assessment and new research insights for exploring the underlying pathological mechanisms in human male infertility syndromes.

The Misalignment of the FT50 with the Achievement of the UN’s SDGs: A Call for Responsible Research Assessment by Business Schools

Publication in the list of 50 journals endorsed by the Financial Times (i.e., the FT50) has become ‘institutionalized’ as a primary measure of research quality and prestige by business schools and faculty. This study investigated the extent to which this closed publication system is (mis)aligned with societal imperatives, in particular the United Nation’s 17 Sustainable Development Goals (SDGs). Research methods included both inductive and deductive analysis. Undergraduate and graduate student research assistants, enrolled in business-related programs, read all 4522 articles published by FT50 journals in 2019 and assessed their relevance to explicit and implicit concepts in the SDG framework. Additionally, potential biases that might stifle research innovation in support of the SDGs were explored. Findings included that 90% of articles were found to have no ‘explicit’ relationship to the SDGs, while only 17% were interpreted as having an implicit relationship. SDG-related articles were disproportionately from one journal-the Journal of Business Ethics (48.1%). There was also an over-representation of observed white male primary authors, who used North American (NA) data sets from NA institutions. A logistic regression model determined that the predicted probability of an SDG-related article increased with observed female primary authors, who used non-NA data sets and institutions. The next steps include comparing this methodological approach with machine learning techniques to find a more efficient and robust method for analyzing an article’s SDG content. Business Schools with sustainability as a core value are encouraged to move beyond FT50 publications for assessing research quality, including for tenure and promotion purposes, and place more focus on assessing research relevance and impact.

Fire Needling Acupuncture for Adult Patients with Acute Herpes Zoster: Protocol of a Systematic Review and Meta-Analysis

BackgroundAcute herpes zoster (HZ) is characterized as a vesicular rash with unilateral distribution produced by the reactivation of varicella zoster virus. It can induce various comorbidities that can adversely influence the quality of life of patients. The purpose of this systematic review is to assess the effect and safety of fire needling acupuncture on acute HZ.MethodsThree English databases (PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials) and four Chinese Databases (China National Knowledge Infrastructure, Wanfang database, Chongqing VIP database, and China Biology Medicine database) will be searched from their inceptions to July 2022. Randomized controlled trials investigating fire needling acupuncture therapy for acute HZ will be included, regardless of publication status. Two reviewers will independently conduct the study screening, data extraction, and research quality assessments. The primary outcome measures are the Pain Visual Analogue Scale and the occurrence of postherpetic neuralgia. Secondary outcomes measures are the evaluation of skin lesions, time to resolution of pain, tolerance evaluation, total effective rate, adverse events and changes in inflammatory and immune suppression markers in peripheral plasma. All included studies will be assessed for methodological quality via the Cochrane Collaboration’s bias risk assessment tool. Meta-analyses will be undertaken using Review Manager V.5.3 software. The findings will be reported as the risk ratio of the binary data and the mean difference (MD) or standardized MD of the continuous data. Subgroup analyses and sensitivity analyses will be conducted where appropriate. The Grading of Recommendations Assessment, Development, and Evaluation will be used to assess evidence certainty.ResultsFrom the study, we will ascertain the effects and safety of fire needling acupuncture on acute HZ.ConclusionThis study will validate the effects and safety of fire needling acupuncture in the management of acute HZ, generating new evidence to guide acupuncture interventions for acute HZ in the future.Registration NumberPROSPERO CRD42020199047.

Randomised controlled trials addressing how the clinical application of information and communication technology impacts the quality of patient care-A systematic review and meta-analysis.

The number of people with chronic and long-term conditions has increased during recent decades; this has been addressed by leveraging information and communication technology (ICT) to develop new self-care solutions. However, many of the developed technological solutions have not been tested in terms of impact(s) on patients' quality of care. This systematic review aimed to identify the current best evidence on the types of interventions that have been developed to improve the quality of patient care through the clinical application of ICT in primary, tertiary or home care. A systematic review, including a meta-analysis, was conducted according to the JBI Manual for Evidence Synthesis guidelines. Relevant data were identified from four electronic databases: CINAHL, PUBMED, SCOPUS and MEDIC. The eligibility criteria were formatted according to PICOS inclusion and exclusion criteria. At least two researchers performed the screening process separately, after which they agreed upon the results. The Cochrane Risk of Bias Assessment and JBI Critical Appraisal tool for randomised controlled studies (RCTs) were used to assess research quality. Data were extracted, and a meta-analysis was performed if the research met quantitative requirements. Of the 528 initially identified studies, 11 studies were chosen for final data synthesis. All of the interventions integrated ICT solutions into patient care to improve the quality of care. Patients across all of the RCTs were educated through direct training, the provision of information relevant to their disease or one-to-one educational coaching. The interventions included various interactions, e.g. nurse expert visits and support, and support provided by peers, groups or family members. These interactions occurred through face-to-face coaching, virtual human coaching or virtual coaching that relied on an algorithm. The performed meta-analysis included 6 of the 11 identified studies. The overall effect was nonsignificant, with three studies demonstrating a significant postintervention effect on patients' quality of care and quality of life and three studies a nonsignificant effect. The presented results suggest that ICT-based care should be developed in collaboration with nurses and other health care professionals, involve patients in decision-making and combine ICT solutions with human interaction and coaching. ICT education was found to be essential to the success of an intervention.

The prevalence of psychological stress in student populations during the COVID-19 epidemic: a systematic review and meta-analysis

Following the COVID-19 outbreak, psychological stress was particularly pronounced in the student population due to prolonged home isolation, online study, closed management, graduation, and employment pressures. The objective of this study is to identify the incidence of psychological stress reactions in student populations following a global outbreak and the associated influencing factors. Four English databases (Pubmed, Embase, Cochrane Library, Web of Science) and four Chinese biomedical databases (Chinese Biomedical Literature Database, VIP Database for Chinese Technical Periodicals, China National Knowledge Infrastructure, Wanfang) were searched in this study. We also retrieved other search engines manually. The search period was from the time of database creation to 10 March 2022. This study included cross-sectional studies related to psychological stress reactions in student populations during the COVID-19 epidemic. Three groups of researchers screened the retrieved studies and assessed the quality of the included studies using the Agency for Healthcare Research and Quality Cross-Sectional Study Quality Assessment Checklist. A random-effects model was used to analyze the prevalence of depression, anxiety, stress, and fear symptoms in the student population during the COVID-19 epidemic. Of the 146,330 records retrieved, we included 104 studies (n = 2,088,032). The quality of included studies was moderate. The prevalence of depressive symptoms in the student population during the epidemic was 32.0% (95% CI [28.0–37.0%]); anxiety symptoms was 28.0% (95% CI [24.0–32.0%]); stress symptoms was 31.0% (95% CI [23.0–39.0%]); and fear symptoms was 33.0% (95% CI [20.0–49.0%]). The prevalence differed by gender, epidemic stage, region, education stage, student major and assessment tool. The prevalence of psychological stress in the student population during the COVID-19 epidemic may be higher compared to the global prevalence of psychological stress. We need to alleviate psychological stress in the student population in a targeted manner to provide mental health services to safeguard the student population.

Saliency-Guided Local Full-Reference Image Quality Assessment

Research and development of image quality assessment (IQA) algorithms have been in the focus of the computer vision and image processing community for decades. The intent of IQA methods is to estimate the perceptual quality of digital images correlating as high as possible with human judgements. Full-reference image quality assessment algorithms, which have full access to the distortion-free images, usually contain two phases: local image quality estimation and pooling. Previous works have utilized visual saliency in the final pooling stage. In addition to this, visual saliency was utilized as weights in the weighted averaging of local image quality scores, emphasizing image regions that are salient to human observers. In contrast to this common practice, visual saliency is applied in the computation of local image quality in this study, based on the observation that local image quality is determined both by local image degradation and visual saliency simultaneously. Experimental results on KADID-10k, TID2013, TID2008, and CSIQ have shown that the proposed method was able to improve the state-of-the-art’s performance at low computational costs.

Mutual information based objective model for assessment of visual quality

The humans are the ultimate assessor of image or video quality. Thus, evaluating the quality using human perception is a very crucial and interesting topic in the quality assessment research domain. Even though the subjective assessment is the most reliable one, it is time consuming and costly. On the other hand, the objective model provides the assessment result with much less time and labour, albeit with certain degree of tolerable error. In this piece of work, a new objective model, namely visual attentive information fidelity (VAIF) has been proposed in the spatial domain, instead of transformed domain, for assessment of visual quality in a scene or in a patch of the scene. VAIF relates mutual information (MI) and image fidelity using source and destination model. The proposed objective model metrics has been correlated with subjective measurement metrics like MOS, NAS.

Database quality assessment in research in paramedicine: a scoping review protocol

IntroductionThe paramedic practice environment presents unique challenges to data documentation and access, as well as linkage to other parts of the healthcare system. Variable or unknown data quality can influence...

Enriching research quality: A proposition for stakeholder heterogeneity

Abstract Dominant approaches to research quality rest on the assumption that academic peers are the only relevant stakeholders in its assessment. In contrast, impact assessment frameworks recognize a large and heterogeneous set of actors as stakeholders. In transdisciplinary research non-academic stakeholders are actively involved in all phases of the research process and actor-network theorists recognize a broad and heterogeneous set of actors as stakeholders in all types of research as they are assigned roles in the socio-material networks, also termed ‘problematizations’, that researchers reconfigure. Actor-network theorists consider research as a performative act that changes the reality of the stakeholders it, knowingly or unknowingly, involves. Established approaches to, and notions of, research quality do not recognize the heterogeneity of relevant stakeholders nor allow for reflection on the performative effects of research. To enrich the assessment of research quality this article explores the problematization as a potential new object of evaluation. Problematizations are proposals for how the future might look. Hence, their acceptance does not only concern fellow academics but also all other human and other-than-human actors that figure in them. To enrich evaluative approaches, this article argues for the inclusion of stakeholder involvement and stakeholder representation as dimensions of research quality. It considers a number of challenges to doing so including the identification of stakeholders, developing quality criteria for stakeholder involvement and stakeholder representation, and the possibility of participatory research evaluation. It can alternatively be summarized as raising the question: for whose benefit do we conduct evaluations of research quality?

Effects of low-FODMAP diet on irritable bowel symptoms in patients with quiescent inflammatory bowel disease: A protocol for a systematic review and meta-analysis.

Inflammatory bowel disease (IBD) is a chronic disease whose etiology is not yet fully understood, and their course is characterized by periods of exacerbation and remission. In quite a few cases, actual disease remission may also accompany with inflammatory bowel disease (IBS)-like symptoms such as abdominal pain, bloating, flatulence, and diarrhea, may greatly impact quality of life. An army of strong evidence to support the FODMAPs diet (LFD) compounds as an effective dietary approach to IBS treatment. However, there is no significant evidence showing the effectiveness of LFD in treating quiescent IBD and its side effects; this lack of evidence is also an important factor hindering its promotion in the treatment of IBD and its complications. Therefore, this systematic review and meta-analysis will evaluate the efficacy and safety of LFD in the treatment of quiescent IBD patients with IBS-like symptoms. We searched the following databases from their establishment until December 2021: PubMed, Web of Science, Embase, Cochrane Library, CNKI, VIP, and Wanfang databases. No restrictions regarding publication date or language were applied. Keywords such as "Crohn's disease," "ulcerative colitis," "inflammatory bowel disease," and "FODMAPs" have been combined for search. Ongoing and unpublished research in the Clinical Trials Registry Research will also be included. At the same time, we will manually search all reference lists from relevant systematic reviews for other eligible studies. The selected studies were randomized controlled clinical trials. We will meta-analyze the selected literature by Review Manager software (REVMAN v5.4 Cochrane Collaboration). Two researchers will independently review the research selection, data extraction, and research quality assessments. Finally, we will observe the outcome measures. This study will provide evidence-based data for TFD treatment of IBD and provide new treatment options for future clinical applications. The protocol of the systematic review does not require ethical approval because it does not involve humans. This article will be published in peer-reviewed journals and presented at relevant conferences. INPLASY202220060.

Mapping Research on miRNAs in Cancer: A Global Data Analysis and Bibliometric Profiling Analysis

miRNAs biomarkers are emerging as an essential part of clinical oncology. Their oncogenic and tumour suppressor properties playing a role in malignancy has generated interest in their potential for use in disease prognosis. While several studies on miRNA have been carried out across the globe, evaluating the clinical implications of miRNAs in cancer diagnosis and prognosis research has currently not been attempted. A study delineating the area of miRNA research, including the topics presently being focused on, the seminal papers in this field, and the direction of research interest, does not exist. This study aims to conduct a large-scale, global data analysis and bibliometric profiling analysis of studies to evaluate the research output of clinical implications of miRNAs in cancer diagnosis and prognosis listed in the SCOPUS database. A systematic search strategy was followed to identify and extract all relevant studies, subsequently analysed to generate a bibliometric map. SPSS software (version 27) was used to calculate bibliometric indicators or parameters for analysis, such as year and country of affiliation with leading authors, journals, and institutions. It is also used to analyse annual research outputs, including total citations and the number of times it has been cited with productive nations and H-index. The number of global research articles retrieved for miRNA-Cancer research over the study period 2003 to 2019 was 18,636. Between 2012 and 2019, the growth rate of global publications is six times (n = 15,959; 90.71 percent articles) that of 2003 to 2011. (2704; 9.29 per cent articles). China published the most publications in the field of miRNA in cancer (n = 7782; 41%), while the United States had the most citations (n = 327,538; 48%) during the time span. Of these journals, Oncotarget has the highest percentage of article publications. The journal Cancer Research had the most citations (n = 41,876), with 6.20 per cent (n = 41,876). This study revealed a wide variety of journals in which miRNA-Cancer research are published; these bibliometric parameters exhibit crucial clinical information on performance assessment of research productivity and quality of research output. Therefore, this study provides a helpful reference for clinical oncologists, cancer scientists, policy decision-makers and clinical data researchers.

Efficacy and safety of acupuncture for patients with pseudomyopia: A protocol for systematic review and meta-analysis.

Background:Myopia are common health problems that people experience in daily life. Pediatric myopia has become a major international public health concern that has a negative impact on physical, mental health of patients, and quality of life. Currently, there is no cure available. Press needle as an adjuvant therapy is currently undergoing clinical trials in different medical centers. However, no relevant systematic review or meta-analysis has been designed to evaluate the effects of press needle patching on early myopia. There is also a lack of systematic evaluation and analysis of acupoints and thumbtack needle.Methods:We will electronically search Medline, Embase, PubMed, Web of Science, the Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, Chinese Scientific Journal Database, and Wan-Fang Database from their inception to October 2021. In addition, we will manually retrieve other resources including the reference lists of identified publications, conference articles, and gray literature. The clinical randomized controlled trials or quasi-randomized controlled trials related to press needle for the treatment of early myopia will be included in the study. The language is limited to Chinese and English. Research selection, data extraction, and research quality assessment will be independently completed by 2 researchers. Data were synthesized by using afixed effect model or random effect model depend on the heterogeneity test. The total effective rate was the primary outcomes. RevMan V.5.3 statistical software will be used for meta-analysis. If it is not appropriate for a meta-analysis, then a descriptive analysis will be conducted. Data synthesis will use the risk ratio and the standardized or weighted average difference of continuous data to represent the results.Results:This study will analyze the clinical effective rate, pesudomyopia outcomes, quality of life, improvement of clinical symptoms of pesudomyopia, and validity of thumbtack needle for patients with pesudomyopia.Conclusion:This systematic review will provide evidence to judge whether thumbtack needle is an effective intervention for patients with early myopia.Systematic review registration:PROSPERO, CRD42021243151.

Prevalence of Anxiety, Depression, and Post-Traumatic Stress Disorder among Children and Adolescents with Cancer: A Systematic Review and Meta-Analysis.

Assessment of psychological and emotional disorders is an important indicator of well-being among children and adolescents with cancer. This review aimed to determine the prevalence rates of three major psychological disorders in this population, including anxiety, depression, and post-traumatic stress disorder (PTSD). Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. Various databases were searched to identify cross-sectional studies assessing anxiety, depression, and PTSD among children and adolescents with cancer. The Joanna Briggs Institute checklist was used to assess research quality. Of the 40 studies included in the literature review, 33 measured anxiety, 28 focused on depression, and nine assessed PTSD. A total of 18 studies were incorporated into the meta-analysis, with pooled prevalence rates of anxiety, depression and PTSD found to be 13.92% (n = 1,971; 95% confidence interval [CI] = 10.23-18.07%), 20.43% (n = 1,990, 95% CI = 13.85-27.93%), and 20.90% (n = 755, 95% CI = 13.28-29.73%), respectively. Mental health and psychological interventions are essential for children and adolescents diagnosed with cancer. Future work should be undertaken in different regions, such as the Middle East or Africa, or South America when assessing the prevalence of psychological disorders in children and adolescents diagnosed with cancer.

Mimicking Individual Media Quality Perception with Neural Network based Artificial Observers

The media quality assessment research community has traditionally been focusing on developing objective algorithms to predict the result of a typical subjective experiment in terms of Mean Opinion Score (MOS) value. However, the MOS, being a single value, is insufficient to model the complexity and diversity of human opinions encountered in an actual subjective experiment. In this work we propose a complementary approach for objective media quality assessment that attempts to more closely model what happens in a subjective experiment in terms of single observers and, at the same time, we perform a qualitative analysis of the proposed approach while highlighting its suitability. More precisely, we propose to model, using neural networks (NNs) , the way single observers perceive media quality. Once trained, these NNs, one for each observer, are expected to mimic the corresponding observer in terms of quality perception. Then, similarly to a subjective experiment, such NNs can be used to simulate the users’ single opinions, which can be later aggregated by means of different statistical indicators such as average, standard deviation, quantiles, etc. Unlike previous approaches that consider subjective experiments as a black box providing reliable ground truth data for training, the proposed approach is able to consider human factors by analyzing and weighting individual observers. Such a model may therefore implicitly account for users’ expectations and tendencies, that have been shown in many studies to significantly correlate with visual quality perception. Furthermore, our proposal also introduces and investigates an index measuring how much inconsistency there would be if an observer was asked to rate many times the same stimulus. Simulation experiments conducted on several datasets demonstrate that the proposed approach can be effectively implemented in practice and thus yielding a more complete objective assessment of end users’ quality of experience.

Distance-Entropy: An Effective Indicator for Selecting Informative Data.

Smart agriculture is inseparable from data gathering, analysis, and utilization. A high-quality data improves the efficiency of intelligent algorithms and helps reduce the costs of data collection and transmission. However, the current image quality assessment research focuses on visual quality, while ignoring the crucial information aspect. In this work, taking the crop pest recognition task as an example, we proposed an effective indicator of distance-entropy to distinguish the good and bad data from the perspective of information. Many comparative experiments, considering the mapping feature dimensions and base data sizes, were conducted to testify the validity and robustness of this indicator. Both the numerical and the visual results demonstrate the effectiveness and stability of the proposed distance-entropy method. In general, this study is a relatively cutting-edge work in smart agriculture, which calls for attention to the quality assessment of the data information and provides some inspiration for the subsequent research on data mining, as well as for the dataset optimization for practical applications.

Medial patellofemoral ligament reconstruction: A review.

Introduction:Reconstruction of the medial patellofemoral ligament (MPFL) is an effective surgical method for the treatment of lateral patellar instability. At present, there is not much controversies regarding the femoral attachment, however, the controversies regarding patellar attachment versus attachment, number of graft strands, tension, isometry and so on. The following electronic databases will be searched: PubMed, the Cochrane Library, Embase, Web of Science, Medline. We will consider articles published between database initiation and March 2021. MPFL in the subject heading will be included in the study. Language is limited to English. Research selection, data extraction, and research quality assessment were independently completed by 2 researchers.Conclusions:MPFL reconstruction is a reliable technique for the treatment of patellofemoral instability. The Schöttle point is still the mainstream method for locating the femoral attachment, the patellar attachment for single-bundle is located at the junction of the proximal one third and the distal two third of the longitudinal axis of the patella. For double-bundles, one is located in the proximal one third of the medial patellar edge and another is in the center of the patellar edge. Meanwhile, the adjustment of graft tension during operation is very important.

Quality assessment of radiomics research in cardiac CT: a systematic review.

To assess the quality of current radiomics research on cardiac CT using radiomics quality score (RQS) and Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD) systems. Systematic searches of PubMed and EMBASE were performed to identify all potentially relevant original research articles about cardiac CT radiomics. Fifteen original research articles were selected. Two cardiac radiologists assessed the quality of the methodology adopted in those studies according to the RQS and TRIPOD guidelines. Basic adherence rates for the following six key domains were evaluated: image protocol and reproducibility, feature reduction and validation, biologic/clinical utility, performance index, high level of evidence, and open science. Among the 15 included articles, six (40%) were about coronary artery disease and six (40%) were about myocardial infarction. The mean RQS was 9.9 ± 7.3 (27.4% of the ideal score of 36), and the basic adherence rate was 44.6%. Fourteen (93.3%) and nine (60%) studies performed feature selection and validation, but only two (13.3%) of them performed external validation. Two studies (13.3%) were prospective, and only one study (6.7%) conducted calibration analysis and stated the potential clinical utility. None of the studies conducted phantom study and cost-effective analysis. The overall adherence rate for TRIPOD was 63%. The quality of radiomics studies in cardiac CT is currently insufficient. A higher level of evidence is required, and analysis of clinical utility and calibration of model performance need to be improved. • The quality of science of radiomics studies in cardiac CT is currently insufficient. • No study conducted a phantom study or cost-effective analysis, with further limitations being demonstrated in a high level of evidence for radiomics studies. • Analysis of clinical utility and calibration of model performance need to be improved, and a higher level of evidence is required.

Stigma against mental health disorders in Nepal conceptualised with a 'what matters most' framework: a scoping review.

Stigma related to mental disorders is a barrier to quality mental healthcare. This scoping review aimed to synthesise literature on stigma related to mental disorders in Nepal to understand stigma processes. The anthropological concept of 'what matters most' to understand culture and stigma was used to frame the literature on explanatory models, manifestations, consequences, structural facilitators and mitigators, and interventions. We conducted a scoping review with screening guided by the Preferred Reporting Items for Systematic Review and Meta-analysis Extension for Scoping Reviews (PRISMA-ScR). A structured search was done using three international databases (PsycINFO, Medline and Web of Science), one Nepali database (NepJol) and cross-referencing for publications from 1 January 2000 through 24 June 2020. The search was repeated to include structural stigma-related terms. Quality of quantitative studies was assessed using the Systematic Assessment of Quality in Observational Research (SAQOR) tool. The review was registered through the Open Science Framework (OSF) (osf.io/u8jhn). The searches yielded 57 studies over a 20-year period: 19 quantitative, 19 qualitative, nine mixed methods, five review articles, two ethnographies and three other types of studies. The review identified nine stigma measures used in Nepal, one stigma intervention, and no studies focused on adolescent and child mental health stigma. The findings suggest that 'what matters most' in Nepali culture for service users, caregivers, community members and health workers include prestige, productivity, privacy, acceptance, marriage and resources. Cultural values related to 'what matters most' are reflected in structural barriers and facilitators including lack of policies, programme planning and resources. Most studies using quantitative tools to assess stigma did not describe cultural adaptation or validation processes, and 15 out of the 18 quantitative studies were 'low-quality' on the SAQOR quality rating. The review revealed clear gaps in implementation and evaluation of stigma interventions in Nepal with only one intervention reported, and most stigma measures not culturally adapted for use. As stigma processes are complex and interlinked in their influence on 'what matters most' and structural barriers and facilitators, more studies are required to understand this complexity and establish effective interventions targeting multiple domains. We suggest that stigma researchers should clarify conceptual models to inform study design and interpretations. There is a need to develop procedures for the systematic cultural adaptation of stigma assessment tools. Research should be conducted to understand the forms and drivers of structural stigma and to expand intervention research to evaluate strategies for stigma reduction.