To investigate the accuracy of a new ray-tracing-based intraocular lens (IOL) power calculation method and to compare the outcomes with different IOL calculation formulas. Hanusch Hospital, Vienna, Austria. Theoretical prospective monocentric study. Monofocal aspheric plate haptic IOL (CT Asphina 409M/MP) implantation was performed in 40 cataractous eyes. At 1month postoperatively, manifest refraction and optical coherence tomography-based biometry (IOLMaster 700) was conducted. The refractive spherical equivalent absolute error of the ray-tracing IOL power calculation method, based on individualized eye model data, a physical lens position predictor, retinal image quality metrics criteria for IOL power selection, and exact IOL design information was calculated and compared with the outcomes using the Barrett Universal II, Hill-RBF, SRK/T, and Haigis formulas. There was no significant difference in absolute errorbetween ray tracing and the Barrett Universal II (0.37 diopter [D]±0.29 [SD]; P=.601) or Hill-RBF (0.39±0.31 D; P=.170). However, the absolute error was significantly lower compared with the Haigis formula (0.42±0.36 D; P=.029) and SRK/T (0.52±0.39 D; P=.020). The refractive prediction of absolute error within ±0.25 D and within ±0.50 D ranged between 48% (ray tracing) and 25% (SRK/T), and between 80% (ray tracing) and 55% (SRK/T), respectively. The new ray-tracing-based IOL power calculation method was an accurate procedure and showed promising preliminary results not only for the refractive outcome, but also for surgeon and patient education as well as the management of patient expectations.