Studies on aerodynamic controls of central-slotted box decks primarily focused on mitigating vortex-induced vibrations (VIV), as this type of deck typically performs well against flutter instability. However, as the span length increases, the critical wind speed of aerodynamic static instability ( U cr) might be lower than flutter critical wind speed. Thus, U cr will determine the overall aerodynamic performance of such bridges. Investigating this instability through wind tunnel testing methods and numerical simulation can be expensive and time-consuming. In this paper, surrogate models using machine learning approaches, specifically artificial neural network (ANN) and extreme gradient boosting (XGBoost), were developed and optimized for fast and reliable prediction for U cr based on wind tunnel tests and simulation data. The results demonstrated that the built surrogate models can predict U cr accurately. The parametric study results showed that the height ratio of wind fairing apex ( a/b), wind angle of attack ( α), and length of the main span ( L) have the most influence on the U cr compared with other parameters. Finally, based on the developed ANN surrogate model and the artificial bee colony (ABC) optimization algorithm, an optimized section was proposed to enhance the section’s performance against aerodynamic static instability.