Objective To understand the present situation of the quality of life and coping style in elderly patients with total knee replacement surgery for more than a year,and analyze its correlation.Methods A questionnaire survey was conducted,General Self-set Questionnaire,health status questionnaire (SF-36) and simplified coping style questionnaire (SCSQ) were used to investigate 160 cases of arthroplasty patients.And 120 health patients were selected as the control group during the same period.Results The score of life quality in patients with artificial total knee replacement was significantly lower than that in the control group [(61.37 ±6.18) vs (79.13 ±4.84)],with significant difference (t =-26.063,P =0.000).Patients with negative coping style score (20.80 ± 5.88) was higher than that in the control group(16.89 ± 2.71),and the difference was statistically significant (t=6.765,P =0.000).Positive coping style was positively correlated with the social functioning,general health,mental health and quality of life score (r =0.214,0.165,0.164,0.268,respectively; P < 0.05); Negative coping style was negatively correlated with the social functioning,general health,vitality,the physiological function (r =-0.205,-0.205,-0.227,-0.261,-0.358,respectively;P < 0.01).Conclusions Quality of life is low in patients with total knee replacement,and the quality of life is correlated with the coping style,so it is necessary to take corresponding nursing interventions to guide the patients to adopt a positive coping style,and provide the necessary social support so as to improve their quality of Key words: Quality of life; Osteoarthritis; Artificial total knee arthroplasty; Coping style